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Veterinary amitraz solution synergist and preparation method thereof

A technology of amphetamine and synergist is applied in the field of veterinary amphetamine solution synergist and its preparation, which can solve the problems of shedding, slow insecticidal effect of amphetamine and the like, so as to reduce the dosage and improve the insecticidal effect. Speed, increased range of effects

Pending Publication Date: 2021-02-09
JIANGSU NANJING AGRI UNIV ANIMAL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the action of amitraz, blood-sucking arthropods are overexcited, so that they cannot attach to the surface of animals and fall
However, the insecticidal effect of amitraz is relatively slow. Generally, lice and ticks can be detached from the body surface 24 hours after the application, and mites can be detached from the affected skin within 48 hours.

Method used

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  • Veterinary amitraz solution synergist and preparation method thereof
  • Veterinary amitraz solution synergist and preparation method thereof
  • Veterinary amitraz solution synergist and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Veterinary amitraz solution synergist

[0035] The raw material ratio is as follows:

[0036]

[0037]

[0038] Prepare various raw and auxiliary materials for preparing 1kg of the target product according to the weight percentage of the formula. Prepared by:

[0039] Step 1, 2-methyl-4-isothiazoline-3-one, 5-chloro-2-methyl-4-isothiazoline-3-one, tea saponin, azadirachtin, lentinan and formula Add 60% purified water into the liquid mixing tank, heat to 60°C and stir to dissolve to obtain solution A;

[0040] Step 2, adding clobetasol propionate into ethanol, stirring and dissolving to obtain solution B;

[0041] Step 3, adding solution B to solution A, stirring while adding, to obtain solution C;

[0042] Step 4, adding polyvinylpyrrolidone K30 into 40% purified water, stirring and dissolving to obtain solution D;

[0043] Step 5, add solution D and water-soluble azone to solution C in sequence, stir and dissolve until uniform, and filter to obtain.

Embodiment 2

[0045] Veterinary amitraz solution synergist

[0046] The raw material ratio is as follows:

[0047]

[0048] Prepare various raw and auxiliary materials for preparing 1kg of the target product according to the weight percentage of the formula. Prepared by:

[0049] Step 1, add 1,2-benzisothiazolin-3-one, ethyl p-hydroxybenzoate, azadirachtin, sanguinarine, lentinan and 60% of the formula amount of purified water into the liquid mixing tank and heat to 60 ℃ stirring and dissolving to obtain solution A;

[0050]Step 2, adding diclofenac sodium into an appropriate amount of purified water, stirring and dissolving to obtain solution B;

[0051] Step 3, adding solution B to solution A, stirring while adding, to obtain solution C;

[0052] Step 4, adding hypromellose to the remaining purified water, stirring and dissolving to obtain solution D;

[0053] Step 5: Add solution D, urea, and propylene glycol to solution C in sequence, stir and dissolve until uniform, and filter ...

Embodiment 3

[0055] Veterinary amitraz solution synergist

[0056] The raw material ratio is as follows:

[0057]

[0058] Prepare various raw and auxiliary materials for preparing 1kg of the target product according to the weight percentage of the formula. Prepared by:

[0059] Step 1, add 5-chloro-2-methyl-4-isothiazolin-3-one, ethyl p-hydroxybenzoate, azadirachtin, matrine, Ganoderma lucidum polysaccharide extract and 70% purified water Mixing tank, heated to 60°C and stirred to dissolve to obtain solution A;

[0060] Step 2, adding triamcinolone acetate into ethanol, stirring and dissolving to obtain solution B;

[0061] Step 3, adding solution B to solution A, stirring while adding, to obtain solution C;

[0062] Step 4, add carmellose to 30% purified water of formula quantity, stir and dissolve to obtain solution D;

[0063] Step 5: Add solution D, water-soluble azone, and propylene glycol to solution C in sequence, stir and dissolve until uniform, and filter to obtain the pr...

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Abstract

The invention discloses a veterinary amitraz solution synergist and a preparation method thereof, and belongs to the technical field of novel veterinary medicine preparations. The raw material of thesynergist comprises the following components in percentage by weight: 0.01-1% of a bactericide or a bacteriostatic agent, 0.01-3% of an anti-inflammatory agent, 1-10% of a functionalizing agent and 1-10% of a penetration enhancer. The veterinary amitraz solution synergist provided by the invention can be used as a diluent of an amitraz solution, can effectively improve the efficacy of amitraz during treatment of animal ectoparasites, is higher in action speed and wider in action range, and can ensure the same or better curative effect while reducing the use amount of amitraz.

Description

technical field [0001] The invention belongs to the field of new veterinary drug preparations, and in particular relates to a veterinary amitraz solution synergist and a preparation method thereof. Background technique [0002] With the improvement of the quality of life and the improvement of environmental protection awareness, higher requirements are put forward for the safety of animal food, the environment and the safety of animal drugs. Research has found that for the same kind of veterinary drug raw materials, the efficacy of the drug often lies in the development and use of combination drugs and synergists. The safety of a veterinary drug preparation for animals, its evaluation criteria include not only the properties of the raw material drug itself, but also the use of different synergists, as well as the excipients and solvents selected for the drug preparation, through compounding and preparation technology research , can effectively improve the curative effect of...

Claims

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Application Information

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IPC IPC(8): A61K31/155A61K31/425A61K31/573A61K31/704A61K31/352A61K31/715A61K31/4741A61K31/196A61K31/4375A61K31/235A61K31/58A61P33/14A61P31/04A61P17/04A61P29/00A61P31/10A61P17/00A61P37/08A61K9/08A61K47/22A61K47/32A61K47/18A61K47/38A61K47/10
CPCA61K31/155A61K31/425A61K31/573A61K31/704A61K31/352A61K31/715A61K31/4741A61K31/196A61K31/4375A61K31/235A61K31/58A61P33/14A61P31/04A61P17/04A61P29/00A61P31/10A61P17/00A61P37/08A61K9/08A61K9/0014A61K47/22A61K47/32A61K47/18A61K47/38A61K47/10A61K2300/00
Inventor 季辉彭麟刘丽万荣峰
Owner JIANGSU NANJING AGRI UNIV ANIMAL PHARM CO LTD
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