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Composite nano material taking vanadium pentoxide as core and application

A vanadium pentoxide and nanoparticle technology, applied in the field of biomedicine, can solve problems such as limited oxygen supply capacity, differences in drug circulation, and excessive drug metabolism, and achieve the effects of improving hypoxia, overcoming self-limitation, and improving tumor perfusion

Inactive Publication Date: 2021-02-09
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the materials used in these methods are mostly focused on improving tumor oxygen content, such as fluorocarbons for direct oxygen delivery and manganese dioxide nanocatalysts for catalyzing the reaction of hydrogen peroxide in tumor tissue to generate oxygen
The oxygen supply capacity of this single method is very limited, and if the oxygen supply agent is used in combination with the PDT photosensitizer, there will be differences in drug circulation and excessive drug metabolism, and the therapeutic effect is very limited

Method used

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  • Composite nano material taking vanadium pentoxide as core and application
  • Composite nano material taking vanadium pentoxide as core and application
  • Composite nano material taking vanadium pentoxide as core and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Preparation of silica-vanadium pentoxide nanoparticles coupled with losartan and iridium complex.

[0048] a. Weigh 1.2g of vanadium pentoxide and 2.5g of oxalic acid dihydrate into 40mL of water and heat it to 60°C for 1 hour, then add it together with 20mL of isopropanol and 10mL of n-butanol into the reaction kettle, and react at 200°C for 12h Afterwards, it was taken out and calcined at 300 degrees for 2 hours to obtain vanadium pentoxide nanoparticles.

[0049] b. APTES (221 mg, 1 mmol) and succinic anhydride (100 mg, 1 mmol) were dissolved in 20 ml dry DCM. After stirring overnight at room temperature, the solvent was evaporated under reduced pressure using a rotary evaporator to obtain carboxysiloxane. HNMR (400MHz, CDCl3): δ=3.86(t,6H),3.42(t,2H),2.60(t,2H),2.50(t,2H),1.51(m,2H),1.21(t,9H) ,0.56(t,3H).

[0050] c. APTES (220 mg, 1 mmol) and triethylamine (200 mg, 2 mmol) were dissolved in 20 mL of anhydrous DCM and stirred in an ice bath for 10 min...

Embodiment 2

[0054] Example 2 Preparation of vanadium pentoxide nanoparticles coated with losartan and iridium complexes

[0055] Referring to steps a-e of Example 1, the corresponding products were prepared in sequence. 200mg iridium complex siloxane and 10mg V 2 o 5 Nanoparticles were added to 50ml anhydrous toluene and sonicated for 0.5h. The solution was heated to 120°C and refluxed for 24 hours. The obtained solid was washed 5 times with toluene, and then dried in vacuum to obtain vanadium pentoxide nanoparticles coated with iridium complexes (IrP@V 2 o 5 ). 65mg IrP@V 2 o 5 Vanadium pentoxide nanoparticles co-coated with iridium complexes and losartan (IrP-L@V 2 o 5 ).

Embodiment 3

[0057] 1mg mL -1 IrP-L@V 2 o 5 and IrP-L@SiO 2 -V 2 o 5 The nanoparticles were respectively placed in 10% fetal bovine serum solution, and then the change of the hydrated particle size was measured by dynamic light scattering. like image 3 As shown, IrP-L@SiO 2 -V 2 o 5 The nanoparticles have better stability and are not easy to aggregate. As time increases, the particle size does not increase significantly. With the IrP-L@SiO of Example 1 2 -V 2 o 5 Compared with, the obtained vanadium pentoxide nanoparticles IrP-L@V of embodiment 2 2 o 5 The stability of the particle is poor, and as time increases, it is easy to aggregate, and the particle size gradually increases, which is easy to cause safety problems such as blood vessel blockage in the body.

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Abstract

The invention provides a composite nano material. The composite nano material takes a vanadium pentoxide nano particle as a core and silicon dioxide as a shell, and the silicon dioxide shell is modified with one or more of a photosensitizer, a hypoxic probe and a tumor microenvironment regulator. According to the composite nano particle, through the synergistic effect of vanadium pentoxide, the photosensitizer, the hypoxic probe, the tumor microenvironment regulator and the like, the problem of hypoxia of tumor tissue in multiple photodynamic therapy processes is solved, and meanwhile, the real-time monitoring of a tumor oxygenation state is realized.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to the synthesis and application of a composite nanomaterial with vanadium pentoxide as the core Background technique [0002] Photodynamic therapy (PDT) is an important cancer therapy that uses light and photosensitizers to generate reactive oxygen species (ROS) to specifically kill cancer cells. It has many advantages, such as reduced systemic toxicity, reduced treatment resistance and minimal invasiveness. While the treatment of PDT needs to consume a large amount of oxygen in the tumor tissue, its therapeutic efficiency is highly dependent on the oxygen content in the tumor. Unfortunately, most tumors are hypoxic due to the lack of tumor vasculature and abnormal proliferation of cancer cells, and the process of PDT further degrades the tumor site due to direct oxygen depletion and damage to tumor vasculature. Oxygen concentrations lead to significant self-restraint. This self-constr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/4178A61K33/24A61K45/06A61K47/52A61K47/54A61K47/58A61K47/60A61K47/69A61P35/00B82Y5/00
CPCA61K31/4178A61K33/24A61K41/0057A61K41/0071A61K45/06A61K47/52A61K47/542A61K47/58A61K47/60A61K47/6929A61P35/00B82Y5/00A61K2300/00
Inventor 蒋锡群李成陈伟芝
Owner NANJING UNIV
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