Preparation method of molecularly imprinted polymer capable of specifically recognizing sildenafil

Abstract

The invention discloses a preparation method of a molecularly imprinted polymer for specifically recognizing sildenafil, and relates to the technical field of new materials. The molecularly imprintedpolymer is obtained by carrying out polymerization reaction on sildenafil molecules, a functional monomer, a cross-linking agent, an initiator, a pore-foaming agent, metal salt and an organic ligand,and removing the sildenafil molecules and metal organic gel formed by the metal salt and the organic ligand after the reaction is finished. Metal organic gel formed in situ in the preparation processof the molecularly imprinted polymer is used as an auxiliary pore-forming solvent and a structure regulator. The molecularly imprinted polymer prepared in the invention realizes specific recognition and high-capacity adsorption of sildenafil molecules, solves the problems of insufficient specific recognition ability and low adsorption capacity of traditional molecularly imprinted polymers to sildenafil in pure water phases, and has good application prospects in the fields of environmental pollution control and the like.

Description

technical field [0001] The invention relates to the field of new materials, in particular to a method for preparing a molecularly imprinted polymer that specifically recognizes sildenafil. Background technique [0002] Pharmaceutical and personal care products (PPCPs), as an emerging class of organic pollutants, pose a potential threat to human and animal health. Sildenafil, used as a drug, is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), and is an oral drug for the treatment of erectile dysfunction. Studies have found that sildenafil has adverse reactions in the cardiovascular system, digestive system, endocrine system, respiratory system, genitourinary system, and central nervous system. In severe cases, it will produce a series of complications and even lead to death. prohibited. However, due to the illegal use of sildenafil, there are residues in the environment, which will pose a certain threat to people's hea...

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Problems solved by technology

However, the surface hydrophobicity of traditional molecularly imprinted polymers makes the interaction with more polar template molecules weak, which greatly reduces its affinity and adsorption capacity for template molecules in pure aqueous phase.

[0004] In recent years, researchers have used hydrophilic monomers as auxiliary functional monomers to synthesize molecularly imprinted polymers with hydrophilic groups on the surface to improve their specific recognition in the aqueous phase, but this method can only be applied In some simple aqueous phase systems (buffer or aqueous solution containing a certain volume of organic phase); or use controlled free radical precipitation polymerization technology to synthesize molecularly imprinted polymer materials with chain transfer active groups on the surface, and then further connect to the surface branched hydrophilic polymer coating to achieve specific recognition of the target in the water phase, but the steps of this method are cumbersome and the adsorption capacity is limited, which is not conducive to the establishment of a simple and efficient method for removing sildenafil pollutants in water

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