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A process for increasing the content of monensin a component

A technology of monensin and component content, applied in the direction of bacteria, microorganism-based methods, microorganisms, etc., can solve the problem of not increasing the content of monensin A component, etc., and achieve strong mycelium metabolism and low price , The effect of rapid growth of mycelium concentration

Active Publication Date: 2021-08-31
内蒙古中牧生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Monensin requires different amounts of nitrogen sources at different stages of the fermentation process, but the existing research only adjusted the preparation method of monensin to obtain a large amount of monensin, but did not improve the yield of monensin. The content of element A component

Method used

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  • A process for increasing the content of monensin a component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] By taking 40kg of soybean meal powder and 10kg of corn steep liquor, adding 1950L of water to prepare a 2000L mixed solution; sterilizing the mixed solution at 121°C for 30 minutes, cooling it down to 35°C naturally, and 44m after fermentation for 200h 3 The monensin fermentation broth was fed into the sterilized mixed solution at a rate of 15L / h; when the fermentation reached 280h, the sterilized mixed solution was fed in at a rate of 10L / h; At 320h, add the sterilized mixed solution at a rate of 8L / h until it is put into the tank.

Embodiment 2

[0024] By taking 40kg of soybean meal powder and 10kg of corn steep liquor, adding 1950L of water to prepare a 2000L mixed solution; sterilizing the mixed solution at 121°C for 30 minutes, cooling it down to 35°C naturally, and 44m after fermentation for 200h 3 Add the sterilized mixed solution to the monensin fermentation broth at a rate of 15 L / h until it is put into the tank.

Embodiment 3

[0026] By taking 30kg of soybean meal powder and 10kg of corn steep liquor, adding them into 1970L of water to prepare a 2000L mixed solution; sterilizing the mixed solution at 121°C for 30min, cooling it down to 35°C naturally, and 44m after fermentation for 200h 3 The monensin fermentation broth was fed into the sterilized mixed solution at a rate of 18L / h; when the fermentation reached 280h, the sterilized mixed solution was fed in at a rate of 13L / h; At 320h, add the sterilized mixed solution at a rate of 9L / h until it is released into the tank.

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Abstract

The invention discloses a process for increasing the content of monensin A component, which comprises the following steps: S1, taking soybean meal powder, corn steep liquor and water in a weight ratio of 3-5:1:190-200, and placing them in a mixing container Mixing in the middle to obtain a mixed solution; S2, carrying out high temperature sterilization of the mixed solution, and cooling after sterilization to obtain a sterilized mixed solution; S3, adding the sterilized mixed solution to the monensin fermentation broth in stages at different flow rates, Fermentation. The applicant of the present invention accidentally found that the metabolism of mycelium in the middle and late stages of fermentation (after 200h) gradually began to decline, the increase in the concentration of mycelium gradually slowed down, and the ability of the mycelium to utilize organic nitrogen sources also showed a downward trend. The input amount and speed of nitrogen source can control the metabolism of mycelium. The applicant adjusts the rate of nitrogen source input in different time periods to make the nutritional balance of the mycelium, so that the mycelium can maintain its vitality for a long time and obtain better quality Metabolism, rapidly increase the concentration of mycelium and increase the content of A component.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a process for increasing the content of monensin A component. Background technique [0002] Monensin, a polyether antibiotic, was first isolated from the fermentation broth of Streptomyces cinnamonensis by Haney et al. in 1967. In the 1970s, it was put on the market as an anticoccidial drug. The United States and Japan officially approved it as a feed additive in 1974 and 1977 respectively, and my country was approved in 1985 and applied to production. At present, more than 40 countries have used it as a weight gain agent for beef cattle and mutton sheep and a growth promoter for pigs. Monensin has no effect on negative bacteria, but has a certain inhibitory effect on Staphylococcus, Bacillus, Clostridium, Streptococcus, and mold (Penicillium, Candida). Monensin can affect the energy metabolism in the rumen of ruminants, improve rumen fermentation, increase the output ratio ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P17/18C12N1/20C12N1/38C12R1/465
CPCC12N1/20C12N1/38C12P17/181
Inventor 李承立颜晓冬靳连标兰玉龙钟建祥
Owner 内蒙古中牧生物药业有限公司
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