A kind of carboxymethyl chitosan containing halogenated benzene and its preparation method and application
A technology of carboxymethyl chitosan and halogenated benzene, which is applied in the field of carboxymethyl chitosan and its preparation, can solve the problems of insufficient support for industrial development and poor biological activity, and achieve good water solubility and antibacterial activity Improve and expand the effect of the application range
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Embodiment 1
[0033] (1) Weigh 1g of chitosan and disperse it in 20mL of isopropanol, add 2.5mL of sodium hydroxide aqueous solution with a mass fraction of 40% dropwise under stirring conditions, stir in a water bath at 50°C for 1h; then use 22mL Dissolve 2.2g of chloroacetic acid in isopropanol, and slowly add it dropwise to the former, and react at 50°C for 4 hours; after the reaction, add absolute ethanol to precipitate, wash with 85% ethanol and suction filter to obtain a filter cake, and dry at 65°C until Constant weight, promptly obtains carboxymethyl chitosan;
[0034] (2) Dissolve 2.2g of carboxymethyl chitosan in deionized water, stir at room temperature for 1 hour until fully dissolved, and then add 5mL of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt salt, 3mL NHS aqueous solution, and adjust the pH to 5 with 1mol / L hydrochloric acid aqueous solution, react at room temperature for 4h, then add 3.6g of aniline, and react at room temperature for 10h in the dark, precipitate a...
Embodiment 2
[0041] The difference from Example 1 is:
[0042] (1) Weigh 1g of chitosan and disperse it in 25mL of isopropanol, add 2.8mL of 40% sodium hydroxide aqueous solution dropwise under stirring conditions, stir and alkalinize in a water bath at 50°C for 1.2h; then use Dissolve 2.5g chloroacetic acid in 30mL isopropanol, and slowly add it dropwise to the former, and react at 50°C for 5h; after the reaction, add absolute ethanol to precipitate, wash with 85% ethanol and suction filter to obtain a filter cake, and dry at 65°C To constant weight, carboxymethyl chitosan is obtained;
[0043] (2) Dissolve 2.2g carboxymethyl chitosan in deionized water, stir at room temperature for 1 hour until fully dissolved, then add 10mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt salt, 6mL N-hydroxysuccinimide aqueous solution, and adjust the pH to 5 with 1mol / L hydrochloric acid aqueous solution, react at room temperature for 5h, then add 4.5g of 2-fluoroaniline, and react in the dark at ro...
Embodiment 3
[0046] The difference from Example 1 is:
[0047] (1) Weigh 1g of chitosan and disperse it in 30mL of isopropanol, add 3.0mL of sodium hydroxide aqueous solution with a mass fraction of 40% dropwise under stirring conditions, stir and alkalinize in a water bath at 50°C for 1h; then use 30mL Dissolve 2.7g of chloroacetic acid in isopropanol, and slowly add it dropwise to the former, and react at 50°C for 6 hours; after the reaction, add absolute ethanol to precipitate, wash with 85% ethanol and suction filter to obtain a filter cake, and dry at 65°C until Constant weight, promptly obtains carboxymethyl chitosan;
[0048] (2) Dissolve 2.2g of carboxymethyl chitosan in deionized water, stir at room temperature for 1 hour until fully dissolved, and then add 5mL of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt salt, 3mL N-hydroxysuccinimide aqueous solution, and adjust the pH to 5 with 1mol / L hydrochloric acid aqueous solution, react at room temperature for 6h, then add 5.0g ...
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