Method for predicting age by using blood marker

A technology of blood markers and age, applied in the field of bioinformatics, can solve the problems of inability to fully reflect individual aging conditions, lack of overall description and interpretation of individual aging, and difficulty in obtaining detection indicators, achieving low cost and high accuracy , the effect of low difficulty of use

Inactive Publication Date: 2021-03-09
天津奇云诺德生物医学有限公司
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AI Technical Summary

Problems solved by technology

[0005] Existing methods for predicting an individual's age only target a certain organ or tissue of the individual, lacking an overall description and explanation of individual aging, and unable to fully reflect individual aging. It is difficult and costly to obtain the indicators that need to be detected in the method of measuring aging and individual age through substances, telomere length, number of immune cells and response effect. Therefore, a method of predicting age using blood markers is designed, which will be used clinically. The more common and easier-to-obtain blood markers can be used as the characteristic value of predicting the individual's physiological age, and can also describe the individual's aging situation more comprehensively, which has practical significance and good application prospects

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Embodiment Construction

[0021] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0022] see figure 1 , a method for predicting age using blood markers, which is a method for evaluating the biological age of subjects using common blood markers, based on 19 blood markers that are significantly correlated with biological age obtained by statistical tests Combining the blood marker data and phenotype data of 92,062 samples collected by the company, a machine learning model was built using the deep neural network (DNN) algorithm, and internal t...

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Abstract

The invention relates to the field of biological information, and discloses a method for predicting age by using a blood marker, which comprises the following four steps of: collecting blood marker data, preprocessing the data, establishing and evaluating a model and testing the model. Compared with other methods and markers, the method has the advantages that the blood marker serves as an evaluation object of the physiological age, the individual aging condition can be reflected more comprehensively, the aging level can be explained more comprehensively, meanwhile, the selected blood marker is predicted through the machine learning model, the process is more intelligent, and the result is more accurate; the selected blood marker, namely a blood biochemical index, is the most common indexin clinical and physical examination institutions, and is low in acquisition difficulty, low in cost and high in interpretation degree.

Description

technical field [0001] The invention relates to the field of biological information, in particular to a method for predicting age using blood markers. Background technique [0002] Aging is an inevitable life stage of an individual, and a continuous, dynamic and slow stage after biological development and maturity. In this stage, individual function declines, physiological structural components gradually degenerate, and a series of Degenerative diseases, such as senile bone hyperplasia, Alzheimer's disease (senile dementia), Parkinson's syndrome, etc. Aging is closely related to disease and death because of the decline in organ function and the changes at the cellular and molecular levels that accompanies aging and progressively affects health. In recent years, research on individual aging has also become a hot research field in life sciences. Aging varies greatly among individuals, and the aging level and speed of various systems and organs of the same individual are not ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B40/00G06N3/04G06N3/08
CPCG16B40/00G06N3/08G06N3/045
Inventor 罗奇斌申玉林廖胜光任毅
Owner 天津奇云诺德生物医学有限公司
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