Sugar-free traditional Chinese medicine mate effervescent tablet and preparation method thereof

An effervescent tablet and sugar-free technology, which is applied in the field of traditional Chinese medicine taste masking, can solve the problems of low-sugar diet crowd resistance to use, taste affecting medication compliance, and children's oral health, and achieves improved compliance, stable properties, and easy portability Effect

Pending Publication Date: 2021-03-12
THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Traditional Chinese medicine is an important means of treating diseases, but good medicine tastes bitter, and the bad taste of Chinese medicine affects people's medication compliance; adding an appropriate amount of carbohydrates to Chinese medicine can improve the taste to a certain extent, but a large number of diabetics, love People on a low-sugar diet and children with dental caries who do not pay attention to oral hygiene all need low sugar intake in their daily diet; although many traditional Chinese medicine companions on the market can improve the taste of traditional Chinese medicine through the sweet ingredients contained in them, but Its sugar content is high, which has the disadvantages of easily causing blood sugar rise in diabetic patients, resistance to use by people with low-sugar diet, and not conducive to children's oral health.
[0003] At the same time, most of the current Chinese medicine companions are powders or granules. If they cannot be used up at one time, they will easily absorb moisture and agglomerate; when using them, they need to open the mouth and pour them into the Chinese medicine decoction, and then accelerate their dissolution by stirring, which has the problem of incomplete dissolution. It is inconvenient to use, so there is an urgent need to develop a Chinese medicine partner effervescent tablet that can dissolve automatically and is sugar-free

Method used

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  • Sugar-free traditional Chinese medicine mate effervescent tablet and preparation method thereof
  • Sugar-free traditional Chinese medicine mate effervescent tablet and preparation method thereof
  • Sugar-free traditional Chinese medicine mate effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) The selected components were crushed separately and passed through a 80-mesh sieve, and the selected mannitol 6.98% was equally divided into two parts; (2) Preparation of composite acid granules: take one part of mannitol, and then take A 5% spartame, 2% sucralose, 0.01% steviol glycoside, 5% vitamin C and 35% anhydrous citric acid were mixed uniformly by equal increment method, using wet granulation technology, with 95% ethanol as Granules made of wetting agent, passed through a 10-mesh sieve, dried in an oven at 50°C for 30 minutes, and prepared for later use; (3) Preparation of compound alkali granules: take another part of mannitol, another 5% of β-cyclodextrin, orange Essence 7%, xylitol 5%, sodium bicarbonate 25%, the above powders are mixed evenly by the equal increase method, and then wet granulation technology is used to make granules with 95% ethanol as a wetting agent, and the granules are passed through a 10-mesh sieve, 45 Dry in an oven at ℃ for 40 minu...

Embodiment 2

[0032] (1) The selected components were crushed separately and passed through a 80-mesh sieve, and the selected mannitol 5.96% was equally divided into two parts; (2) Preparation of composite acid granules: take one part of mannitol, and then take A Spartame 6%, sucralose 3%, steviol glycoside 0.02%, vitamin C 2% and anhydrous citric acid 35%, were mixed uniformly by equal increment method, using wet granulation technology, with 95% ethanol as Granules made of wetting agent, passed through a 10-mesh sieve, dried in an oven at 50°C for 30 minutes, and prepared for later use; (3) Preparation of compound alkali granules: take another part of mannitol, another 10% of β-cyclodextrin, orange Essence 8%, xylitol 2%, sodium bicarbonate 25%, the above powders are mixed uniformly by the equal increase method, and then wet granulation technology is used to make granules with 95% ethanol as a wetting agent, and the granules are passed through a 10-mesh sieve, 45 Dry in an oven at ℃ for 40...

Embodiment 3

[0034] (1) The selected components were crushed separately and passed through a 80-mesh sieve, and the selected mannitol 5.94% was equally divided into two parts; (2) Preparation of composite acid granules: take one part of mannitol, and then take A 12% of Spartame, 1% of Sucralose, 0.02% of Steviol Glycoside, 3% of Vitamin C and 25% of Anhydrous Citric Acid were mixed uniformly by the method of increasing in equal volume, using wet granulation technology, with 95% ethanol as Granules made of wetting agent, passed through a 10-mesh sieve, dried in an oven at 50°C for 30 minutes, and prepared for later use; (3) Preparation of compound alkali granules: take another part of mannitol, another 15% of β-cyclodextrin, orange Essence 5%, xylitol 8%, sodium bicarbonate 20%, the above powders are mixed uniformly by the equal volume increasing method, and then wet granulation technology is used to make granules with 95% ethanol as a wetting agent, and the granules are passed through a 10-...

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Abstract

The invention discloses a sugar-free traditional Chinese medicine mate effervescent tablet and a preparation method thereof. The sugar-free traditional Chinese medicine mate effervescent tablet comprises the following specific components in percentage by weight: 0.01-30% of a sweetening agent; 0.01%-25% of an aromatic agent; 0.01%-20% of beta- cyclodextrin; 10%-70% of an acid agent and an alkali agent; 1%-10% of a filler; 1%-5% of a lubricant; 0.01%-0.04% of a coloring agent; and 1%-10% of a flavoring agent. The preparation method comprises the following steps: respectively preparing compositeacid granules and composite alkali granules by adopting a wet granulation process, uniformly mixing the prepared composite acid granules and composite alkali granules, adding a lubricant and a coloring agent, finally uniformly mixing, and tabletting to prepare 2g / tablet sugar-free traditional Chinese medicine mate effervescent tablets. The sugar-free traditional Chinese medicine mate effervescenttablet disclosed by the invention does not contain any sugar component capable of increasing blood sugar and causing decayed teeth, and has the advantages of small volume, refined dosage, no need ofstirring, high dissolving speed and the like.

Description

technical field [0001] The invention relates to the technical field of taste-masking of traditional Chinese medicines, in particular to a sugar-free traditional Chinese medicine partner effervescent tablet and a preparation method thereof. Background technique [0002] Traditional Chinese medicine is an important means of treating diseases, but good medicine tastes bitter, and the bad taste of Chinese medicine affects people's medication compliance; adding an appropriate amount of carbohydrates to Chinese medicine can improve the taste to a certain extent, but a large number of diabetics, love People on a low-sugar diet and children with dental caries who do not pay attention to oral hygiene all need low sugar intake in their daily diet; although many traditional Chinese medicine companions on the market can improve the taste of traditional Chinese medicine through the sweet ingredients contained in them, but Its sugar content is high, which has the disadvantages of easily c...

Claims

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Application Information

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IPC IPC(8): A61K47/26A61K47/46A61K47/18A61K47/69
CPCA61K47/26A61K47/46A61K47/183A61K47/6951
Inventor 桂新景刘瑞新李学林李海洋张璞张璐姚静施钧瀚王艳丽
Owner THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF TCM
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