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Sterol database establishment and sterol analysis method

A technology for establishing methods and databases, applied in the field of data analysis, can solve problems such as low accuracy of sterol identification

Pending Publication Date: 2021-04-09
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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Problems solved by technology

[0004] In order to solve the above problems, the application provides a sterol database establishment and a sterol analysis method based on the sterol database, which can solve the problem of low accuracy of sterol identification at present

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  • Sterol database establishment and sterol analysis method
  • Sterol database establishment and sterol analysis method

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[0084] The following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of them. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of this application.

[0085] The terms "first", "second" and the like in the specification and claims of the present application are used to distinguish similar objects, and are not used to describe a specific sequence or sequence. It should be understood that the terms so used are interchangeable under appropriate circumstances such that the embodiments of the application can be practiced in sequences other than those illustrated or described herein, and that references to "first," "second," et...

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Abstract

The invention discloses establishment of a sterol database and a sterol analysis method based on the sterol database. According to the method, four-dimensional information of first sterol can be obtained specifically through liquid chromatography tandem ion mobility mass spectrometry, the four-dimensional information comprises collision cross-sectional area information, chromatographic retention time, primary mass spectrometry information and secondary mass spectrometry information, and prediction models of information of all dimensions in the four-dimensional information of the first sterol are established respectively; and then, the four-dimensional information of the second sterol is determined according to the prediction model of each dimension information, a sterol database is established according to the four-dimensional information of the first sterol and the four-dimensional information of the second sterol, the target sterol in the to-be-detected sample then is analyzed through the sterol database, and the identification result information corresponding to the target sterol is deteremined. Therefore, the four-dimensional information of sterol is obtained through a liquid chromatography-tandem ion mobility mass spectrometry technology, so that high separation of sterol isomers is realized, and high-accuracy and high-coverage sterol identification can be realized.

Description

technical field [0001] The present application relates to the technical field of data analysis, in particular to the establishment of a high-coverage sterol database and a sterol analysis method based on the sterol database. Background technique [0002] Sterols have important physiological functions and are closely related to major diseases such as cardiovascular diseases, cancer and neurodegenerative diseases. Sterolomics is to comprehensively analyze the changes of sterol metabolic pathways and metabolic networks by detecting the metabolic levels of various sterols in the body, so as to reveal its significance for diseases. [0003] Currently, the analytical objects of sterolomics mainly rely on limited, commercially available sterol standards. In this way, only a small amount of sterols can be determined, and the coverage is low, which cannot meet the analysis requirements of sterolomics. Moreover, in the analysis process of sterolomics, sterols are generally separated...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16C20/30G16C20/90
CPCG16C20/30G16C20/90
Inventor 朱正江李彤洲
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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