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A kind of green production technology of uracil

A production process, uracil technology, applied in the chemical field, can solve problems such as heavy pollution, expensive thiourea, and serious environmental pollution

Active Publication Date: 2022-07-15
ZHEJIANG BENLI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This route uses thiourea as a cyclic compound, and then synthesizes uracil through oxidation. The process is repeated, and a large amount of sulfur-containing substances are produced in the post-treatment, causing great pollution.
And thiourea is more expensive than urea
The production cost is higher and the environmental pollution is serious, so this route is not advisable

Method used

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  • A kind of green production technology of uracil
  • A kind of green production technology of uracil
  • A kind of green production technology of uracil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 12.0g (0.2mol) of urea, the same R 3 Molar amounts of different basic substances were added to 60 g of xylene, and the temperature was raised to 60 °C with stirring for 4 h. Distill out xylene and low boilers, and dry in vacuo to obtain urea alkali metal salt.

[0045]

Embodiment 2

[0047] 12.0 g (0.2 mol) of urea and 10.8 g (0.2 mol) of sodium methoxide were added to 60 g of xylene, stirred and heated to different temperatures to react for 4 h. The xylene and methanol were distilled off, and the urea sodium salt was obtained by vacuum drying.

[0048]

Embodiment 3

[0050] 12.0 g (0.2 mol) of urea and 10.8 g (0.2 mol) of sodium methoxide were added to 60 g of xylene, and the temperature was raised to 60°C with stirring for different times. The xylene and methanol were distilled off, and the urea sodium salt was obtained by vacuum drying.

[0051]

[0052]

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PUM

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Abstract

The invention relates to the field of chemistry, and specifically provides a green production process for uracil. The invention cyclizes 3-alkoxy (amino) acrylate (amide) and urea alkali metal salt, and then converts it into uracil after acidification , the yield is over 95%.

Description

technical field [0001] The invention relates to the field of chemistry, in particular to a green production process of uracil. Background technique [0002] Uracil is a base unique to RNA and is one of the four constituent bases that make up RNA. It is an important intermediate in the synthesis of antitumor drugs 5-fluorouracil, antiviral drugs, AIDS drugs, hepatitis B drugs uridine, iodine, and is also an important intermediate in the synthesis of 2-chloro-4-amino-5-nitropyrimidine, 2, It is an important raw material for pharmaceutical intermediates such as 4-dichloropyrimidine, 2,4-dibromopyrimidine, 5-hydroxymethyluracil, etc. It is widely used and in great demand. [0003] At present, there are many routes for synthesizing uracil. In the patent application publication number CN107793366A, a route for synthesizing uracil with malic acid, urea and oleum as raw materials is provided. The method has serious pollution, cumbersome post-processing, and the yield is about 50%...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D239/54
CPCC07D239/54
Inventor 吴政杰顾海宁欧阳凯
Owner ZHEJIANG BENLI TECH CO LTD