Dehydroepiandrosterone derivatives, drugs with anti-flavivirus activity and applications thereof
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A technology of dehydroepiandrosterone and flavivirus, which is applied in the direction of antiviral agents, organic active ingredients, medical preparations containing active ingredients, etc., can solve the problem of limited antiviral activity, limited efficacy of antiflavivirus activity, water-soluble Insufficient sex and other problems, to achieve the effect of improving normal cell lesions and excellent anti-flavivirus activity
Active Publication Date: 2022-03-04
HUAZHONG AGRI UNIV
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[0006] However, the anti-flavivirus activity of the above-mentioned compounds or derivatives is limited, and at the same time, there may also be technical defects such as high cytotoxicity and poor water solubility, which further limit their antiviral activity.
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Embodiment 1
[0040] Example 1 of the present invention provides a dehydroepiandrosterone derivative, which is denoted as AV1004, and its preparation route is: modifying the 17th position of the parent body of dehydroepiandrosterone, and introducing a new group from the perspective of structure-activity relationship , the modified site and structural formula changes are shown in the following formula:
[0041]
Embodiment 2
[0124] Example 2 of the present invention provides a drug with anti-flavivirus activity comprising the above-mentioned dehydroepiandrosterone derivative (AV1004), which uses dehydroepiandrosterone derivative (AV1004) as an active ingredient and has excellent Anti-flavivirus function. The dosage form of the drug can be adjusted according to actual application needs, and is not limited here.
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Abstract
The invention provides a dehydroepiandrosterone derivative, a drug with anti-flavivirus activity and application thereof. The dehydroepiandrosterone derivative has excellent efficacy in inhibiting flavivirus, and can significantly improve normal cell pathology caused by flavivirus infection at a concentration that has no toxic effect on cells. The dehydroepiandrosterone derivative or the drug containing it with anti-flavivirus activity can be used alone or in combination with other anti-flavivirus drugs to prepare flavivirus inhibitors or drugs for treating flavivirus diseases, and has great application prospects .
Description
technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a dehydroepiandrosterone derivative, a drug with anti-flavivirus activity and an application thereof. Background technique [0002] The Flavivirus family (Flaviviridae) is an enveloped single-stranded positive-sense RNA virus, which is transmitted by blood-sucking arthropods (mosquitoes, ticks, sandflies, etc.) to cause infection. The flavivirus genus includes about 70 viruses, most of which are pathogens of zoonotic infectious diseases, such as Japanese encephalitis virus (Japanese encephalitis virus, JEV), West Nile virus (WNV), yellow fever Virus (Yellow fever virus, YFV), 1-4 type dengue virus (Dengue virus, DENV) and Zika virus (Zika virus, ZIKV), etc. [0003] Flavivirus infection can cause symptoms such as fever, headache, joint pain, conjunctivitis, rash and itching, and in severe cases, death of the infected person. In recent years, with the change of globa...
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