Novel application of plant extract in preparing medicament for treating light type alcoholic hepatic disease

A technology of alcoholic liver disease and extract, which is applied in the field of medicine, can solve the problems of lack of medicine, etc., and achieve the effect of promoting reversal, reducing content, and improving liver tissue lesions

Inactive Publication Date: 2010-02-24
CHENGDU LIST PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in addition to alcohol abstinence and symptomatic treatment, there is still a lack of effective drugs for the clinical treatment of ALD.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation of the ethanol extract of embodiment 1 Tibetan fungi

[0014] Take 1120g of Caprena chinensis, chop it up, reflux extract with 10 times the amount of 85% ethanol three times, each time for 3 hours, combine the extracts, filter, and concentrate the filtrate under reduced pressure to form a clear paste with a relative density of 1.18-1.20 (60°C). Instantly.

Embodiment 2

[0015] The preparation of embodiment 2 Tibetan fungi chen water extract

[0016] Take 1120g of Capillary Capsicae, chop it, extract three times with 10 times the amount of purified water, 3 hours each time, combine the extracts, filter, concentrate to a relative density of 1.04-1.06 (60°C), add ethanol, and adjust the ethanol concentration to 85 %, stand still for 24 hours, filter the above-mentioned ethanol solution, recover ethanol from the filtrate and continue to concentrate into a clear paste to obtain final product.

Embodiment 3

[0017] The preparation of embodiment 3 Erythrina chinensis water extract

[0018] Take 1120g of Capillary cypress, chop it up, extract three times with 10 times the amount of 0.2% NaOH solution, each time for 3 hours, combine the extracts, filter, concentrate to a relative density of 1.04-1.06 (60°C), add ethanol to adjust the ethanol concentration 85%, let stand for 24 hours. The above-mentioned ethanol solution is filtered, and the ethanol is recovered from the filtrate and then concentrated into a clear paste.

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PUM

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Abstract

The invention provides a novel application of a tibetan capillaries extract in preparing a medicine for treating the light type alcoholic liver disease. The extract comprises an ethanol extract, a water extract and an alkali water extract; proportioning according to the mass of tibetan capillaris, a white rat is fed with the tibetan capillaries extract according to 4.0g of crude medicine/kg. Experiments prove that the tibetan capillaries has a therapeutic action to a model with light type alcoholic liver injuries caused by alcohol and can promote the reversion of the light type alcoholic liverinjuries of the white rat caused by the alcohol.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the new application of the extract of the Tibetan capillary wormwood in the preparation of medicines for treating mild alcoholic liver disease. Background technique [0002] Zang Yin Chen is the dry whole plant of Swertia mussotii Franch, Swertia mussotii Franch, S. franchetiana H. Smith, and Halenia elliptic D. Don. [0003] Tibetan Yinchen is a precious medicinal material for Tibetan medicine to prevent and treat various diseases such as hepatitis, liver fibrosis, and fatty liver. According to phytochemical research, the Tibetan capillary plant contains secoiridoid glycosides, flavonoids and their glycosides, xanthone and its glycosides, triterpenes and other components. Among them, the split iridoid glycosides such as swertiamarin, gentiopicroside, and swertigin have pharmacological effects such as protecting the liver, reducing enzymes, anti-inflammation, promoting liver...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61P1/16
Inventor 黄绍渊张浩
Owner CHENGDU LIST PHARMA
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