33 results about "DHEA - Dehydroepiandrosterone" patented technology

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising an anti-IgE antibody for the treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease.

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for the treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases.

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising an antihistamine for the treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease.

The invention discloses a composition for resisting ageing and improving male energy. The composition is prepared from a raw material and an auxiliary material; the raw material is prepared from the following components in parts by weight: 1-15 parts of nicotinamide mononucleotide, 1-10 parts of protopanoxadiol, 1-9 parts of icarisid I, 2-8 parts of baohuoside I, 3-7 parts of dehydroepiandrosterone and 2-10 parts of ursodesoxycholic acid. The composition is reasonable in composing prescription and proper in compatibility; in the composition, the four of the nicotinamide mononucleotide (NMN), the icarisid I, the baohuoside I and protopanoxadiol are used as monarch drugs together, the composition is capable of comprehensively regulating gonad axis and invigorating kidney-yang and liver, candelay ageing period of the gonad axis and improve the sexual function after being taken for a long time; through intercoordination and synergistic effect of various components, the composition is comprehensive in nutrition, has very good palatability, is particularly suitable for males to take and thus relieving the symptoms of male ageing syndrome and improving the male energy. The invention alsoprovides a preparation containing the composition and a preparation method of the preparation. The preparation method is simple, is moderate in condition and is suitable for industrial batch production.

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a β2-agonist bronchodilator for the treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases.

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising an anticholinergic bronchodilator for the treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases.

The invention discloses a method for detecting the content of DHEA in human body fluid. The method comprises the steps of detecting dehydroepiandrosterone in saliva by using a high performance liquid chromatography-tandem mass spectrometry technology, specifically, S1, adding the following reagents into a kit: a mobile phase I, a mobile phase II, a standard substance mother solution, an internal standard solution, a diluent, an extracting solution, a quality control substance and a redissolving solvent; S2, detecting the dehydroepiandrosterone in the pretreated saliva by adopting the high performance liquid chromatography-tandem mass spectrometry technology; S3, separating the dehydroepiandrosterone from the interferent by using high performance liquid chromatography; S4, quantifying by using an isotope internal standard method; S5, taking the concentration ratio of the standard substance to the internal standard substance as an X axis and the peak area ratio of the standard substance to the internal standard substance as a Y axis; and S6, establishing a standard curve, and calculating the content of the dehydroepiandrosterone in the sample to be detected. The method is high in sensitivity and good in specificity, saliva sample treatment is simple, methodology verification meets requirements, and it is indicated that the method is reliable and capable of being applied to quantitative detection of dehydroepiandrosterone in human saliva.

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a phosphodiesterase-4 inhibitor for the treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease.

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a cromone for the treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease.

The invention belongs to the technical field of formula production, and particularly relates to a Chinese yam and radix angelicae soup formula and a preparation method thereof. Chinese yam has the effects of tonifying spleen and stomach, promoting salivation and tonifying lung, and tonifying kidney and arresting seminal emission, and can promote brain to secrete dehydroepiandrosterone so as to improve sleep, nourish blood vessels and nerves, preserve a good mood and enhance body immunity; radix angelicae can relieve exterior syndrome, dispel cold, dispel wind, relieve pain, eliminate dampness,arreseting leucorrhea, diminish swelling and expel pus, and also has the effects of exciting central nerves, increasing hypertension, resisting inflammation, easing pain, resisting cancer and relieving spasm; honeysuckle has the effects of clearing away heat and toxic materials and diminishing inflammation and swelling; liquorice is added into the formula, so that the taste of Chinese yam and radix angelicae soup can be adjusted, and the Chinese yam and radix angelicae soup has a sweet taste, is convenient for a drinker to drink, and also can eliminate phlegm to arrest coughing and tonify qito moisten the lung; and through cooperative use of a cleaning unit and a soil brushing mechanism, soil on the surfaces of the Chinese yam can be conveniently flushed, and the cleaning effect is good.

The invention relates to a method and a kit for detecting the content of dehydroepiandrosterone in saliva, and the method comprises the following steps: preparing a standard substance, preparing a quality control substance, treating the standard substance, analyzing and detecting by adopting a high performance liquid chromatography-tandem mass spectrometry technology, pre-treating a saliva sample, analyzing and detecting by adopting the high performance liquid chromatography-tandem mass spectrometry technology, drawing a calibration curve: establishing a standard curve by adopting an isotope internal standard quantification method by taking the concentration ratio of a standard substance to an internal standard substance as an X axis and the peak area ratio of the standard substance to the internal standard substance as a Y axis, and calculating the content of the dehydroepiandrosterone in the to-be-detected sample. According to the method, dehydroepiandrosterone and interferents are separated by adopting the high performance liquid chromatography-tandem mass spectrometry technology, then the content of dehydroepiandrosterone in saliva is measured by combining an isotope internal standard quantification method, and the dehydroepiandrosterone reacts with methoxyamine to generate oxime ester, so that the detection sensitivity is remarkably improved, and the detection time is shortened. The specificity of the detection method is ensured by adopting a reaction detection mode (MRM).

The invention discloses a preparation method of a skin-moistening and anti-wrinkle cosmetic. The preparation method comprises the following steps: step I, adding squalane, silyl carotene, cetyl, beewax, propyl p-methoxycinnamate and dimethyl siloxane into a container A, performing heating to 75-85 DEG C, and performing stirring at 100-200r/min for 20-40min to obtain a mixed solution A; step II, adding a humectant, polyoxyethylene hydrogenated castor oil, fumed silica, sodium hyaluronate and deionized water into a container B, performing heating to 85-95 DEG C, performing stirring at the speedof 100-200 r/min for 20-40 min, and performing cooling to 75-85 DEG C to obtain a mixed solution B; step III, adding the mixed solution B into a vacuum homogenizing tank, then slowly adding the mixedsolution A into the mixed solution B which is stirred at the speed of 50-100 r/min, controlling the temperature to be 70-80 DEG C, then performing homogenizing and emulsifying for 3-10 minutes at therotating speed of 500-1000 r/min, performing stirring at the rotating speed of 50-100 r/min, and performing cooling to 35-45 DEG C to obtain a pre-emulsified solution; and step IV, adding a natural anti-aging agent, dehydroepiandrosterone, a free radical scavenger, a preservative and essence into the pre-emulsified solution in parts by mass, performing stirring at the speed of 50-100 r/min and thetemperature of 35-45 DEG C for 30-60 minutes to obtain emulsified solution, and performing ageing for 1-3 days to obtain the skin-moistening and anti-wrinkle cosmetic. The cosmetic with excellent skin moistening and anti-wrinkle performance is prepared through the preparation method.

A method of improving sexual function in premenopausal women, who have low Female Sexual Function Index (FSFI) baseline of less than or equal to 25.7. The method includes providing information to premenopausal women to provide input for calculating the FSFI score and, if the score is low, providing dehydroepiandrosterone (DHEA) supplementation to be taken in 25 mg dosages daily once, twice, thrice or four times over a period of time of four to six weeks. By the end of the period of time, the FSFI baselines of the premenopausal women improves by at least seven percent, serum androgen levels of the premenopausal women increase and follicle-stimulating hormone (FSH) levels of the premenopausal women decrease.

A pharmaceutical two-phase admixture for topical application, transdermal or transmucosal, characterized by components in two phases, a liquid and a solid, adapted for topical application, transdermal or transmucosal, to various skin and/or mucosal surface areas of the body is disclosed. The solid phase is comprised of one or more bio-identical hormones and the liquid phase is comprised of one or more excipient carrier oils. The bio-identical hormone component is comprised of one or more of Bi-Est, testosterone, progesterone, and dehydroepiandrosterone. The excipient carrier oil component is comprised of one or more of a wide range of common and rare pharmacological oils including specific formulations of jojoba oil, evening primrose oil, and borage seed oil. The solid phase bio-identical hormone component is comprised of either a standard coarse formulation or a formulation comprised of nanoparticles. The pharmaceutical admixture is especially useful in a regime of hormone replacement therapy.

The invention relates to a synthesis method of a medicine, in particular to a preparation method of maxacalcitol. The maxacalcitol is prepared by taking dehydroepiandrosterone as an initial raw material through acylation, Grignard reaction, oxidation, saponification, hydroxyl protection, epoxidation, reduction, elimination, NBS bromination/dehydrobromination, deprotection and illumination ring opening, the operation is simple, the yield is high, and the maxacalcitol is suitable for large-scale industrial production.

The invention discloses a dehydroepiandrosterone health-care food and a making method thereof, and relates to the technical field of health-care foods. The problem that vitamins cannot be supplementedto women in the gestation period is solved. The dehydroepiandrosterone health-care food comprises the following components by weight: 50mg of DHEA and 400mg of folic acid. The making method of the dehydroepiandrosterone health-care food comprises the following steps: respectively weighing the DHEA, the folic acid, vitamin A and vitamin B6 in parts by weight. The health-care food is used for supplementing vitamins, minerals and trace elements for pregnant women and lactating women, helps normal development of brain and nervous systems of fetuses, promotes erythrocyte formation, improves body immunity of the pregnant women, is suitable for iron deficiency and folic acid in the pregnant period, and can meet special requirements of females in the gestation period and the lactation period forother nutritional ingredients every day. Various vitamins and other trace elements daily required by such crowds are comprehensively supplemented, so that the purpose of improving anemia is achieved.