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A kind of dexamethasone acetate cream and preparation method thereof

A technology of dexamethasone acetate and cream, applied in the direction of ointment delivery, pharmaceutical formula, emulsion delivery, etc., can solve the problems of antibacterial and stability reduction, and achieve the effect of stable antibacterial and stability, and enhanced stability

Active Publication Date: 2022-07-08
SINOPHARM GRP SANYI PHARMA WUHU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Dexamethasone acetate ointment is a product listed in the standard edition of the Ministry of Health, but its antibacterial properties and stability will decrease after a long period of storage. Therefore, the company re-developed on the basis of the previous research on triamcinolone acetonide urea ointment Research to further improve the stability and antibacterial properties has reached the requirements of the Ministry of Health standard

Method used

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  • A kind of dexamethasone acetate cream and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0020] A dexamethasone acetate cream, which is composed of dexamethasone acetate, perilla leaf extract, clear cod liver oil, paste and stabilizer;

[0021] The paste includes stearic acid, white petrolatum, light liquid paraffin, glycerin, and purified water;

[0022] The stabilizer is a mixture of poly-γ-glutamic acid, citric acid and sodium caprylate;

[0023] The weight ratio of the dexamethasone acetate, perilla leaf extract, clear cod liver oil, paste and stabilizer is 1:0.8:0.6:0.8:0.8;

[0024] The weight ratio of the poly-γ-glutamic acid, citric acid and sodium caprylate is 1:0.5:0.5.

[0025] The preparation method of above-mentioned dexamethasone acetate cream, comprises the following steps:

[0026] 1) Water phase: put the purified water into the water phase pretreatment pot, add glycerin and mix well, then add poly-γ-glutamic acid, citric acid and sodium caprylate, stir and mix well, and set aside for use;

[0027] 2) oil phase: put the weighed stearic acid into...

Embodiment 2

[0031] A dexamethasone acetate cream, which is composed of dexamethasone acetate, perilla leaf extract, clear cod liver oil, paste and stabilizer;

[0032] The paste includes stearic acid, white petrolatum, light liquid paraffin, glycerin, and purified water;

[0033] The stabilizer is a mixture of poly-γ-glutamic acid, citric acid and sodium caprylate;

[0034] The weight ratio of the dexamethasone acetate, perilla leaf extract, clear cod liver oil, paste and stabilizer is 1:1:1:1:1;

[0035] The weight ratio of the poly-γ-glutamic acid, citric acid and sodium caprylate is 1:0.5:0.5.

[0036] The preparation method of above-mentioned dexamethasone acetate cream, comprises the following steps:

[0037] 1) Water phase: put the purified water into the water phase pretreatment pot, add glycerin and mix well, then add poly-γ-glutamic acid, citric acid and sodium caprylate, stir and mix well, and set aside for use;

[0038] 2) oil phase: put the weighed stearic acid into the oil...

Embodiment 3

[0042] A dexamethasone acetate cream, which is composed of dexamethasone acetate, perilla leaf extract, clear cod liver oil, paste and stabilizer;

[0043] The paste includes stearic acid, white petrolatum, light liquid paraffin, glycerin, and purified water;

[0044] The stabilizer is a mixture of poly-γ-glutamic acid, citric acid and sodium caprylate;

[0045] The weight ratio of the dexamethasone acetate, perilla leaf extract, clear cod liver oil, paste and stabilizer is 1:0.8:0.6:0.8:0.8;

[0046] The weight ratio of the poly-γ-glutamic acid, citric acid and sodium caprylate is 1:0.5:0.5.

[0047] The preparation method of above-mentioned dexamethasone acetate cream, comprises the following steps:

[0048] 1) Water phase: put the purified water into the water phase pretreatment pot, add glycerin and mix well, then add poly-γ-glutamic acid, citric acid and sodium caprylate, stir and mix well, and set aside for use;

[0049] 2) oil phase: put the weighed stearic acid into...

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Abstract

The invention discloses a dexamethasone acetate cream and a preparation method thereof. The cream comprises dexamethasone acetate, perilla leaf extract, clear cod liver oil, paste and stabilizer. Compared with the prior art, the invention enhances the antibacterial properties, moisturizing properties and stability of dexamethasone acetate, so that the content of the dexamethasone acetate cream is stable and has strong antibacterial properties.

Description

technical field [0001] The invention belongs to an ointment and a preparation method thereof, in particular to a dexamethasone acetate cream and a preparation method thereof. Background technique [0002] Dexamethasone acetate ointment is a standard listed by the Ministry of Health, but its antibacterial properties and stability will be reduced after long-term storage, so the company re-launched on the basis of the previous research on triamcinolone acetonide acetate urea ointment Research to further improve the stability and antibacterial properties has reached the requirements of the Ministry of Health standard. SUMMARY OF THE INVENTION [0003] The first technical problem to be solved by the present invention is to provide a dexamethasone acetate cream with good antibacterial properties and stability. [0004] The second technical problem to be solved by the present invention is the preparation method of the above cream. [0005] The technical scheme for solving the t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/573A61K36/535A61K47/34A61K47/12A61P31/04A61P31/10A61K35/60
CPCA61K9/06A61K31/573A61K36/535A61K35/60A61K47/34A61K47/12A61P31/04A61P31/10A61K2300/00
Inventor 裴义海骆后峰吴灿灿章绍凡
Owner SINOPHARM GRP SANYI PHARMA WUHU CO LTD
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