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System and method for screening and evaluating tumor immunotherapy drugs

A tumor and immune cell technology, applied in the field of biomedicine, can solve the problems such as the inability to effectively improve the anti-tumor immune system, the increased risk of new drug research and development, and the failure of tumor immunotherapy to achieve the expected results.

Pending Publication Date: 2021-05-11
ADLAI NORTYE BIOPHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the improvement of the anti-tumor immune system is often not achieved only by relying on a single type of cell, but requires a variety of immune cells to cooperate with each other; In addition to the target-related immune cells, it will inevitably act on other non-target immune cells, and if this effect will hinder the normal function of other immune cells, even if the drug has a better effect on the target-related immune cells There will also be a great possibility that the anti-tumor immune system cannot be effectively improved, resulting in the failure of tumor immunotherapy to achieve the expected effect
However, the routine research and development of new drugs for tumor immunotherapy lacks effective methods to circumvent the effects of drugs, which will increase the risk of new drug development

Method used

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  • System and method for screening and evaluating tumor immunotherapy drugs
  • System and method for screening and evaluating tumor immunotherapy drugs
  • System and method for screening and evaluating tumor immunotherapy drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0091] 1. A method for evaluating the effect of a test substance on tumor immune cells, comprising the steps of: i) evaluating the effect of the test substance on target cells, ii) evaluating the effect of the test substance on non-target cells; and iii) evaluating The impact of the test substance on tumor immune infiltration;

[0092] Wherein said step i) comprises:

[0093] i-1) assessing the effect of the test substance on the target cells of the immune cell line, and

[0094] i-2) assessing the impact of the test substance on primary immune cell target cells;

[0095] Wherein, after the evaluation of the step i-1), the evaluation result is divided into positive (+) and negative (-), and for the test object whose evaluation result is no, no further steps are performed and It was directly judged as a negative test substance.

[0096] 2. The method according to embodiment 1, wherein for the test substance whose evaluation result in the step i-1) is positive, proceed to the...

Embodiment

[0164] The target cells of the test substances A, B, C and D used in this embodiment are T lymphocytes, so the immune cell line target cells Jurkat cells used are human-derived T lymphocyte leukemia cells, and the primary T lymphocytes analyzed Cell target cells are T cells in human peripheral blood mononuclear cells (PBMC).

[0165] 1. Immune cell line target cell testing submodule

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Abstract

The invention relates to a system and method for effectively screening and evaluating tumor immunotherapy drugs. The method comprise effect evaluation of target cells, such as effect evaluation for primary immune cell target cells, non-target cell effect evaluation and tumor infiltration effect evaluation. The system and the method disclosed by the invention can be used for comprehensively and systematically evaluating the effectiveness and the safety of the drugs relative to the tumor immune cells.

Description

technical field [0001] This application relates to the field of biomedicine, in particular to a system and method for screening and evaluating tumor immunotherapy drugs. Background technique [0002] Tumor immunotherapy refers to a treatment method that uses drugs to modify and maintain tumor-immune microcirculation, improve the body's anti-tumor immune effect, and achieve the effect of controlling or even eliminating tumors. In the process of developing new drugs for tumor immunotherapy, the effective evaluation of drug effectiveness and safety is a crucial factor to ensure the successful development of related drugs. In the routine development of new drugs for tumor immunotherapy, the effectiveness of relevant immune cells is targeted based on the expression characteristics of the target. However, the improvement of the anti-tumor immune system is often not achieved only by relying on a single type of cell, but requires a variety of immune cells to cooperate with each oth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/02G16B40/00
CPCG01N33/505G01N33/5052G01N33/5055G01N33/5047G01N33/5023G16B40/00G01N2500/10G01N33/5011
Inventor 何南海王友平路杨杨东晖
Owner ADLAI NORTYE BIOPHARMA CO LTD