Three Chinese magnoliavine fruit extracts as well as preparation process and application thereof

Abstract

The invention discloses three Chinese magnoliavine fruit extracts as well as a preparation process and application thereof, and belongs to the technical field of medicines. The preparation method of the Chinese magnoliavine fruit extract comprises the following steps: treating Chinese magnoliavine fruit by using a CSFE method to obtain an extract A, and placing the extract at room temperature for layering to obtain an extract B (rich in schisandrin B) and an extract C (rich in schizandrin); boiling the decoction dregs, adding beta-cyclodextrin into filtrate to carry out inclusion adsorption on residual fat-soluble active ingredients in the decoction dregs, and filtering to obtain the inclusion adsorption lignan; performing concentration and alcohol precipitation on the filtrate to obtain the Chinese magnoliavine fruit polysaccharide; respectively combining the inclusion adsorption lignan and polysaccharide with the extracts A, B and C to obtain an extract I, an extract II and an extract III. The content of effective parts of the three extracts accounts for more than 50% of the extracts, the three extracts are composed of three active components including total lignan, linoleic acid and polysaccharide, and the total lignan is 18-25%. Different new drugs can be developed from the three extracts according to different proportions of schisandrin B and schizandrin for resisting depression, promoting sleep, promoting intelligence and other indications.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to three kinds of schisandra extracts and their preparation process and application. Background technique [0002] Schisandra chinensis (Northern Schisandra) is mainly distributed in northeast my country and northern Inner Mongolia. The fruit is used as medicine. It is mainly used for anti-depression, sleep, sedation, intelligence development, liver protection, and hypoglycemic effect. The main pharmacodynamic active ingredient of Schisandra chinensis is the total lignans of Schisandra chinensis, and the lignans with the highest content are schisandrin A and schisandrin B. Studies have shown that the content of alcohol A in the dried and mature fruit of Schisandra chinensis is much higher than that of alcohol B. The quality standard of Schisandra chinensis recorded in the Chinese Pharmacopoeia in 2015, the content is determined by high performance liquid chromatography, and the dr...

AI Technical Summary

Problems solved by technology

[0005] The main active components of Schisandra chinensis, total lignans, are all fat-soluble components. If the total lignans are to be extracted efficiently, the CSFE conditions selected are usually able to highly enrich non-polar components such as schisandra B, which is relatively lipophilic. process conditions, and such process conditions cannot fully propose the relatively large polar alcohol form in the total lignans of Schisandra chinensis

Thereby, still lack at present the method for more fully extracting the total lignans and other active ingredients in Schisandra fruit

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