A green light-responsive polymer nano drug carrier

A nano-drug carrier and polymer technology, applied in the field of biomedical materials, can solve the problems of limiting the clinical application of polymer nano-drug carriers, and achieve the effects of avoiding light damage, large drug loading, and realizing release.

Active Publication Date: 2022-02-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, UV light itself has certain phototoxicity, which limits the clinical application of UV-responsive polymeric nano-drug carriers.

Method used

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  • A green light-responsive polymer nano drug carrier
  • A green light-responsive polymer nano drug carrier
  • A green light-responsive polymer nano drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of furan derivatives: Dissolve 1.51g of Michaelis acid or 1,3-dimethylbarbituric acid and 0.961g of furfural in 30mL of water, react at room temperature for 16h; after the reaction is completed, filter and wash with water, A yellow solid was obtained; the yellow solid was redissolved in dichloromethane, washed successively with saturated sodium bisulfite solution, ultrapure water, saturated sodium carbonate solution and saturated sodium chloride solution; finally dried over anhydrous magnesium sulfate, filtered and rotary evaporation treatment to obtain furan derivatives;

[0030] (2) Preparation of polyethylene glycol-b-poly(hexyl acrylate-co-pentafluorophenyl methacrylate): 1 part of 2-(dodecyltrithiocarbonate)-2-methyl Polyethylene glycol monomethyl ether propionate, 0.05 parts of azobisisobutyronitrile, 4 parts of pentafluorophenyl methacrylate, and 40 parts of hexyl acrylate were dissolved in 1 mL of dioxane, and reacted at 60 ° C for 2 h; After co...

Embodiment 2

[0035] (1) Preparation of furan derivatives: Dissolve 1.51g of Michaelis acid or 1,3-dimethylbarbituric acid and 0.961g of furfural in 30mL of water, and react at room temperature for 16h; after the reaction is completed, filter and wash with water. A yellow solid was obtained; the yellow solid was redissolved in dichloromethane, washed successively with saturated sodium bisulfite solution, ultrapure water, saturated sodium carbonate solution and saturated sodium chloride solution; finally dried over anhydrous magnesium sulfate, filtered and rotary evaporation treatment to obtain furan derivatives;

[0036](2) Preparation of polyethylene glycol-b-poly(hexyl acrylate-co-pentafluorophenyl methacrylate): 5 parts of 2-(dodecyltrithiocarbonate group)-2-methyl Polyethylene glycol monomethyl ether propionate, 0.1 part of azobisisobutyronitrile, 5 parts of pentafluorophenyl methacrylate, and 60 parts of hexyl acrylate were dissolved in 5 mL of dioxane, and reacted at 75 ° C for 15 h; ...

Embodiment 3

[0041] (1) Preparation of furan derivatives: Dissolve 1.51g of Michaelis acid or 1,3-dimethylbarbituric acid and 0.961g of furfural in 30mL of water, react at room temperature for 16h; after the reaction is completed, filter and wash with water, A yellow solid was obtained; the yellow solid was redissolved in dichloromethane, washed successively with saturated sodium bisulfite solution, ultrapure water, saturated sodium carbonate solution and saturated sodium chloride solution; finally dried over anhydrous magnesium sulfate, filtered and rotary evaporation treatment to obtain furan derivatives;

[0042] (2) Preparation of polyethylene glycol-b-poly(hexyl acrylate-co-pentafluorophenyl methacrylate): 10 parts of 2-(dodecyltrithiocarbonate group)-2-methyl Polyethylene glycol monomethyl ether propionate, 0.2 parts of azobisisobutyronitrile, 8 parts of pentafluorophenyl methacrylate, and 80 parts of hexyl acrylate were dissolved in 10 mL of dioxane, and reacted at 90 ° C for 30 h; ...

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Abstract

The invention discloses a green light responsive polymer nano drug carrier. It is characterized in that a green light-responsive amphiphilic (hydrophilic and lipophilic) macromolecule containing a donor-acceptor Steinhaus adduct is first synthesized, and then the macromolecule and the drug self-assemble in a solution to form vesicles, Finally, green light-responsive nano drug carriers loaded with hydrophilic / hydrophobic drugs were obtained. The nano-drug carrier prepared by this patent uses low-energy green light as a response switch, which avoids the problem of light damage to biological tissues caused by the excitation light source; compared with the traditional polymer micelle drug carrier, the polymer vesicle drug carrier prepared by this method It has a larger drug loading capacity, more drug loading and drug release modes.

Description

technical field [0001] The invention specifically relates to a green light-responsive polymer nano-medicine carrier, which belongs to the field of biomedical materials. Background technique [0002] In recent years, stimuli-responsive nano-drug carriers have been approved for clinical use because they can enrich anti-cancer drugs in the lesion and reduce the toxic and side effects of corresponding drugs, and have become an important development direction in the field of nano-medicine. So far, pH-responsive, redox-responsive, light-responsive, thermal-responsive, and enzyme-responsive nano-drug carriers have been developed. Among them, photoresponsive polymer nano-drug carriers have been extensively studied due to their unique advantages. First of all, the light-responsive polymer nano-drug carrier has the advantages of strong design, non-toxicity in vivo and long circulation, and can increase the drug concentration at the lesion site, reduce the injection volume, and reduce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/127A61K31/337A61K31/513A61K31/52A61K31/704A61K31/7068A61K47/32A61P35/00C08F293/00C08F8/32C08F8/00C08F8/30
CPCA61K9/1273A61K41/0042A61K47/32A61K31/704A61K31/337A61K31/513A61K31/7068A61K31/52A61P35/00C08F293/00C08F8/32C08F8/00C08F8/30A61K2300/00
Inventor 向均林建勋范浩军陈意颜俊马浩
Owner SICHUAN UNIV
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