Preparation method and application of novel fluorescent nano material with photodynamic therapy and sterilization functions

Abstract

The invention relates to the technical field of high polymer materials, biological medicines and nano materials, in particular to a preparation method and application of a novel fluorescent nano material with photodynamic therapy and sterilization functions. The preparation method comprises the following steps: dissolving an aniline compound and amino acid with deionized water, adding concentrated sulfuric acid after dissolving, and uniformly stirring and mixing; and transferring the uniformly mixed solution to a polytetrafluoroethylene reaction kettle, and carrying out hydrothermal reaction to obtain the novel macromolecular fluorescent nano material with the spiral structure. The fluorescent nano material can immediately generate hydroxyl free radicals, singlet oxygen and superoxide anion radical free radicals after being illuminated by ultraviolet light, visible light, laser and the like, and has extremely strong oxidation characteristics; when free radicals are generated, body color and fluorescence are changed, the generation of the free radicals can be judged according to the body color and fluorescence characteristics, and according to the characteristics of the photosensitizer, the photosensitizer can be applied to the fields of photodynamic therapy, photodynamic bacteriostasis and the like.

Description

technical field [0001] The invention relates to the technical fields of polymer materials, biomedicine and nanometer materials, in particular to a preparation method and application of a novel fluorescent nanometer material with photodynamic therapy and bactericidal functions. Background technique [0002] Nanotechnology refers to the design and synthesis of nanomaterials in the range of 1-100nm for functional materials, sensors and devices, etc. In this scale range, nanomaterials usually have large specific surface area, high chemical reactivity and easy absorption by organisms. Fluorescent nanomaterials mainly include carbon nanodots and carbon nanotubes. Because of their low biotoxicity, good biocompatibility, small size, and unique fluorescent properties, they are widely used in disease diagnosis, drug delivery, and biological It has been widely used in the fields of therapy, in vivo imaging, tumor targeting and so on. At present, there are few nanomaterials with photo...

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies in the prior art, the technical problem to be solved in the present invention is to provide a simple synthesis method, degradable, high phototoxicity, and the like based on the shortcomings of the existing PSs synthesis path, such as complex synthesis path, high biological toxicity, and long illumination time. New fluorescent nanomaterials that require short illumination time and have both Type I and Type II PSs characteristics

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