Polysaccharide-based tissue bonding medical adhesive and application thereof

A polysaccharide and tissue technology, used in applications, medical science, surgical adhesives, etc., can solve the problems of fast degradation time, low viscosity, and poor water resistance in vivo.

Active Publication Date: 2021-05-18
稳得希林(杭州)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the defects of poor impact resistance, low viscosity, poor interstitial performance to porous and rough surfaces, fast degradation time in vivo, no heat resistance, and poor water resistance, this adhesive has been restricted in its application in medicine to a certain extent. limitations

Method used

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  • Polysaccharide-based tissue bonding medical adhesive and application thereof
  • Polysaccharide-based tissue bonding medical adhesive and application thereof
  • Polysaccharide-based tissue bonding medical adhesive and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of polysaccharide-based tissue-adhesive medical glue: the dextran (structural formula is: wherein m=5-2000, n=1-1800, degree of substitution 90%) and 0.5 g of branched polyethyleneimine are dissolved in 50 mL of deionized water, and stirred for 6 hours. After routine purification, drying, and grinding, the powdered polysaccharide-based tissue-adhesive medical glue 1 is obtained,

Embodiment 2

[0030] Preparation of polysaccharide-based tissue adhesive medical glue: 2g oxidized sodium alginate powder (structural formula is: wherein m=20-1000, n=1-900, degree of substitution 70%) mixed with 0.8 g of dopamine hydrochloride powder to obtain powdery polysaccharide-based tissue-adhesive medical glue 2.

Embodiment 3

[0032] The preparation of polysaccharide-based tissue-adhesive medical glue: the pullulan (structural formula is:

[0033] wherein m=15-4000, n=1-3600, substitution degree 5%) and 0.6 g of α-cyclodextrin were dissolved in 60 mL of deionized water, and stirred for 3 hours. After routine purification, drying, and grinding, the powdery polysaccharide-based tissue-adhesive medical glue 3 was obtained.

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Abstract

The invention discloses a polysaccharide-based tissue bonding medical adhesive and application thereof. The polysaccharide-based tissue bonding medical adhesive is composed of a polysaccharide derivative and a compound with at least two reaction functional groups, wherein the polysaccharide derivative and the compound with at least two reaction functional groups generate a bonding effect through one or more of a physical effect and a chemical reaction; and the polysaccharide derivative is polysaccharide after functional group substitution. The polysaccharide-based tissue bonding medical adhesive can bear relatively large tension, has relatively short tissue bonding time and relatively high tissue stripping force compared with a cyanoacrylic acid medical adhesive, can realize rapid bonding and sealing of wounds, has strong adhesion with tissues after being applied, is not easy to strip, can be suitable for stretched wounds, and can realize effective closing.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to polysaccharide-based tissue bonding medical glue and its application. Background technique [0002] Medical glue refers to the preparation, material or substance that can adhere to the surface or cause adhesion between surfaces in medical applications, mainly used for local adhesion and repair of organs or tissues, replacing traditional sutures; or tissues, blood vessels The combination and positioning of plugging and other technical fields. Compared with traditional methods such as suturing and stapling, the use of medical glue can effectively shorten the operation time and significantly reduce the patient's pain. In tissue bonding, bonding generally involves the following aspects: 1. The adhesion between the internal activities of living tissue; 2. The adhesion between the organism and the medical glue; 3. The adhesion between the medical glue of adhesion. An important part...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/001A61L24/043C08L5/08C08L5/04C08L5/12C08L3/02C08L1/02C08L5/00C08L5/02C08L5/16
Inventor 徐福建李杨
Owner 稳得希林(杭州)生物科技有限公司
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