Lipid barrier repair

Abstract

The present disclosure is in the field of ointments which can be useful for the treatment of diseases or conditions associated with lipid barrier damage of the skin. The ointment comprises a semifluorinated alkane and a solid thickening agent, e.g. a wax, a triglyceride, cetyl alcohol, cetyl palmitate or tetradecanol.

Description

[0001] The present invention relates to ointments comprising semifluorinated alkanes. The ointment of the present invention can be used as an ointment base for the preparation of other pharmaceutical or cosmetic compositions. In particular, the ointment of the present invention can be used for the treatment of skin diseases and disorders associated with damage to the lipid barrier of the skin, such as psoriasis, dermatitis, acne and related symptoms. Background technique [0002] Ointments are semisolid preparations intended for external application to the body. Therapeutically, ointments function as skin protectants and emollients, but they are mainly used as vehicles or bases for topical application of medicinal substances. Ideally, an ointment base should be skin-compatible, stable, long-lasting, smooth and flexible, non-irritating, non-sensitizing, inert and capable of readily releasing the drug into which it is incorporated. Ointments are best classified according to th...

AI Technical Summary

Problems solved by technology

Vegetable oils and animal fats have two distinct disadvantages as ointment bases: they have a low water absorption capacity, and they have a tendency to go rancid

Strong odor from ingredients and greasy composition may be unpleasant for patients

In addition, low pH and sensory responses (due to e.g. lactic acid and urea) may reduce patient acceptance

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