11 results about "Skin lipid" patented technology

The application belongs to the technical field of microorganisms and particularly relates to a Bifidobacterium adolescentis beneficial to skin, a derivative of the Bifidobacterium adolescentis and application of the Bifidobacterium adolescentis and the derivative. The derivative of the Bifidobacterium adolescentis has significant antioxidant and anti-inflammatory effects, can inhibit pathogenic bacteria of acne and other common skin infections such as Propionibacterium acnes, Staphylococcus aureus and Malassezia furfur, can eliminate pathogenic bacteria, can inhibit skin lipid accumulation, can avoid follicle blockage, and can improve skin problems in multiple directions, especially acne skin problems.

The invention discloses a sebum-imitated recombinant collagen anti-oxidation anti-aging brightening composition and a preparation method thereof, the sebum-imitated recombinant collagen anti-oxidation anti-aging brightening composition is of a core-shell double-phase structure, and the sebum-imitated recombinant collagen anti-oxidation anti-aging brightening composition comprises an aqueous phase core, an aqueous phase core and a composite material, the active ingredient of the aqueous phase core is a covalent bond of carboxymethylated recombinant human collagen III and eclipta oligopeptide; the oil-phase layer wraps the water-phase core and comprises a sebum-imitating three-phase film as well as an antioxidant active matter and a slow-release carrier which are dispersed in the sebum-imitating three-phase film; wherein the volume ratio of the water-phase core to the oil-phase layer is 1: 2-1: 4, a core-shell double-phase structure with the carboxymethylated recombinant collagen-eclipta oligopeptide covalent bond as the water-phase core and the sebum-imitating three-phase membrane functional carrier as the oil-phase layer is constructed, and the limitation that active ingredients in a traditional formula are simply mixed is broken through. According to the structure, the stability of the water phase core is ensured through a chemical covalent bond, and the percutaneous permeability and biocompatibility of the composition are remarkably improved by utilizing the high similarity of a sebum-imitating film and skin lipid.

The invention discloses a skin care moisturizer preparation method, which comprises: S1, heating an oil phase component to a molten state under a vacuum condition to obtain a homogeneous oil phase; s2, mixing and swelling a water phase component containing a macromolecular thickening agent under a heating condition to obtain a homogeneous water phase; s3, mixing the water phase and the oil phase under a vacuum condition, shearing and homogenizing at 70-80 DEG C to form a primary emulsion, and then starting to cool; s4, when the temperature of the system is reduced to a first preset temperature interval, adding a first group of active substances and uniformly dispersing; and S5, when the temperature of the system is continuously reduced to a second preset temperature interval, adding a second group of active substances, uniformly dispersing, and then adjusting the pH value of the system to 5.5-6.0. According to the present invention, the ceramide, the recombinant collagen and the decarboxylated carnosine are adopted, and the ceramide and the squalane are adopted to simulate the skin lipid so as to actively repair the barrier;

The invention relates to a quaternary lipid barrier repairing composition which is prepared from the following raw materials: tea-seed oil, camellia-seed oil, a phytosterol derivative and meadowfoam seed oil. Through compounding of the tea-seed oil, the camellia-seed oil, the phytosterol derivative and the meadowfoam seed oil, multi-dimensional barrier repair synergy of passive supplement, active repair and antioxidant protection is realized. The quaternary lipid system is highly similar to a human body sebum membrane structure, and can rapidly fill up cuticle lipid gaps, significantly reduce transdermal moisture loss and efficiently repair a skin physical barrier; the phytosterol derivative can be cooperated with the tea-seed oil and the camellia-seed oil, lipid components can be directly supplemented, a skin lipid synthesis mechanism can be activated, skin endogenous generation proportion-coordinated cholesterol-ceramide-free fatty acid is guided, and self-reconstruction of a barrier is achieved; the meadowfoam seed oil has excellent oxidation resistance, so that secondary damage of oxidative stress to lipid can be effectively resisted, and the stability and durability of repair are ensured.

This invention relates to a method for preparing verbascoside and its application in promoting skin lipid production, belonging to the technical field of skin care and topical products. The method includes the following steps: Selecting dried fleshy stems of *Cistanche deserticola*, *Cistanche tubulosa*, *Cistanche salsa*, and *Cistanche salsa* (all belonging to the Orobanchaceae family), pulverizing them after pretreatment, and extracting them with 50%-80% ethanol aqueous solution under reflux for 2-4 times, 1-3 hours each time. The extracts are combined and concentrated under reduced pressure until no alcohol odor remains, obtaining a concentrated solution. The concentrated solution is passed through an AB-8 macroporous adsorption resin column, eluted sequentially with deionized water and 30%-50% ethanol aqueous solution to remove impurities, and then eluted with 60%-90% ethanol aqueous solution to remove the target component. The eluent is collected and concentrated under reduced pressure, purified by silica gel column chromatography using chloroform-methanol at a volume ratio of 5:1-2:1 as the eluent. The target fraction is collected, concentrated under reduced pressure, and freeze-dried to obtain the purified verbascoside. The beneficial effects of this invention are: verbascoside has a skin-protective effect and exhibits superior skin-care activity when applied to products.

The present application belongs to the field of polypeptide drug preparation, and particularly relates to a kind of short peptide dimer and its nanocomposite.The tripeptide (Ser-Cys-Arg) is assembled to form short peptide dimer by hydrogen bond in aqueous solution, which first discloses that short peptide forms cyclic dimer structure through intermolecular hydrogen bond, without using chemical crosslinking agent, oxidizing agent or protection / deprotection step, and the process is more simple and mild, and more suitable for synergistic assembly with drug molecules to form nanocomposite.The short peptide dimer provided by the present application can efficiently encapsulate model drugs to form "peptide-drug" nanocomposite, which can diffuse in gel matrix to epidermis, form multiple non-covalent interactions with skin lipids and keratin, significantly improve the transdermal permeability of drugs through dual pathways of cell penetration and intercellular gap transport, and reach the action site to realize efficient targeted drug release.

The present application relates to a plant extract-based liposoluble antioxidant and skin lightening composition and its skin care product. The plant extract-based liposoluble antioxidant and skin lightening composition comprises the following components by mass fraction: 5-50 of deep sea fish oil, 0.05-2 of tomato fruit extract & jojoba seed oil & squalane compound, and 0.05-1 of jojoba seed extract & olive fruit oil compound. The present application improves the skin lipid content through the synergistic effect of deep sea fish oil, tomato fruit extract & jojoba seed oil & squalane compound, and jojoba seed extract & olive fruit oil compound, resists oxidation in multiple dimensions, removes free radicals, reduces collagen loss, inhibits melanin production, increases skin hyaluronic acid content, enhances the ability of cells to resist oxidation, improves the glossiness and elasticity level of skin cells, and ultimately achieves the effects of antioxidant and overall whitening and skin lightening.

Coconut oil and prunus amygdalus dulcis oil are used as a moistening base, simmondsia chinensis seed oil is matched to enhance the stability of the formula, and pure natural plant essential oil such as angelica sinensis and crocus sativus is compounded, so that muscle tension and aching pain can be directly relieved through the anti-inflammatory and blood-activating effects, and the body soothing effect is achieved. Qi and blood circulation can be promoted, invasion of wind, cold and damp exogenous evil is reduced, and qi stagnation and blood stasis are conditioned from the source; meanwhile, the base oil can supplement skin lipids, repair body surface barriers and provide a stable skin basis for body soothing, essential oil molecules can also act on a neuroendocrine system, relieve emotion pressure and indirectly relieve body tension, a complete closed loop from physiological conditioning and skin care to emotion soothing is finally formed, and the comfortable experience of body and mind synchronization is achieved.

The invention relates to the technical field of cosmetics, and discloses an anti-wrinkle whitening emulsion mask and a preparation method thereof, and space partition loading and pH response slow release of water-soluble and fat-soluble active ingredients are realized by constructing a bicontinuous phase liquid crystal type microemulsion system. According to the mask, the transdermal efficiency, the storage stability and the skin feeling are effectively improved. The contained multi-target active ingredients synergistically exert anti-wrinkle, whitening and barrier repairing effects, and 28-day human body tests show that wrinkles, melanin indexes and skin elasticity are remarkably improved. By accurately designing the bicontinuous phase structure of the liquid crystal type micro-emulsion, spatial isolation and synergistic delivery of the water-soluble anti-wrinkle peptide, the whitening agent and the fat-soluble barrier repairing component are realized, unstable active matters are protected by utilizing a pH partitioning strategy, and the transdermal efficiency and the skin feeling comfort are improved through the molecular matching property of the liquid crystal structure and skin lipid; the core problems of component interference, poor stability, insufficient permeation and the like in the prior art are solved.

The invention belongs to the technical field of preparation of daily necessities, and particularly relates to a moisturizing and soothing composition containing sodium hyaluronate and application of the moisturizing and soothing composition in skin care of infants and children. The hyaluronic acid moisturizing mask is prepared from the following raw materials in parts by mass: 0.01 to 0.05 part of sodium hyaluronate, 5 to 25 parts of a moisturizing component, 0.01 to 0.7 part of a soothing component and 0.1 to 6 parts of a skin moistening component, the moisturizing component is prepared from at least one of glycerol, 1, 3-butanediol and 1, 3-propylene glycol; the soothing component is prepared from at least one of allantoin, bisabolol and a radix gentianae extract; the skin moistening component comprises shea butter and / or hydrogenated coconut oil. After the sodium hyaluronate is added, the composition can promote the metabolism of cuticle cells and assist in barrier repair; after the moisturizing component and the relieving component are compounded, the composition can directly supplement skin lipid, form a protective layer, inhibit release of inflammatory factors and relieve redness and stabbing caused by barrier damage, and is suitable for delicate skin of infants and children.

The invention relates to a whitening composition, modified glutathione and a preparation method thereof. The preparation method of the modified glutathione specifically comprises the following steps: 1) obtaining a liposome suspension, performing ultrasonic dispersion, mixing the liposome suspension with hyaluronidase and a cross-linking agent, and stirring to obtain a HAase-Lip suspension; and 2) mixing glutathione with the HAase-Lip suspension, carrying out a stirring reaction, and carrying out ultrasonic treatment to obtain the glutathione-Lip composite material. The phospholipid bilayer vesicle structure of Lip can form a physical barrier, so that the efficacy attenuation is greatly delayed. Meanwhile, a skin-like lipid structure of Lip can be fused with a cuticle lipid bilayer, the nanoscale particle size of Lip can be matched with the cuticle gap size, and Lip penetrates through the cuticle by means of the permeation mechanism of Lip; on the other hand, HAase has the capability of degrading hyaluronic acid on the surface layer of the skin, assists Lip and internal GSH to permeate into the deep layer of the epidermis, and reduces the damage of transdermal penetration to the skin barrier.