59 results about "Skin lipid" patented technology

The invention discloses a whitening agent liposome coating micro-capsule composition as well as a preparation method and an application thereof. The whitening agent liposome coating micro-capsule composition comprises 5-30% of whitening agent, 2-50% of polyhydric alcohol, 1-30% of phospholipids, 1-30% of grease, 1-10% of emulsifying agent and 1-30% of deionized water, wherein the whitening agent is coated by lecithin which is very similar to a skin lipid structure and is prone to penetrating into the deep layer of skin, thus the defect that the whitening agent is unlikely to be absorbed by the skin is overcome; the whitening agent coated by lecithin is isolated from oxygen in air, thus the detect that the whitening agent is prone to being oxidized and discoloring is solved; when whitening products containing the whitening agent liposome coating micro-capsule composition are used, the whitening agent is slowly released and has a long-time whitening effect.

Topical anti-microbial compositions, and more particularly anti-bacterial and anti-fungal compositions, comprising a therapeutically effective amount of an anti-microbial agent, a starch, a hydroalcoholic solvent, and a volatile silicone compound having a viscosity of about 0.1 to about 50 centistokes. These compositions are capable of temporarily or permanently reducing, inhibiting, treating, ameliorating, or preventing microbial skin infections, as well as other related skin conditions. These compositions are further capable of restoring or repairing a skin lipid barrier of a mammal.

Skin protectant compositions that are free of cholesterol and suitable for topical application to skin of a mammal. In a preferred embodiment, these skin protectant compositions comprise a ceramide; a squalane; a phytosterol-containing liposome; a phospholipid-containing ingredient; at least one triglyceride; and at least one dermatologically acceptable excipient. These compositions are capable of restoring or repairing a skin lipid barrier of a mammal, and treating skin conditions associated therewith.

A skin-care composition containing a protective component providing protection of the skin from environmental damage and regulating natural moisture of the skin; a skin firming component; and a barrier component. Thus, the composition includes at least one component that supports the collagen structure, and at least one component that supports the body's own defense / repair mechanisms, and most preferably, at least one component that supports the skin lipid system.

Topical skin protectant compositions, and more particularly anti-pruritic skin protectant compositions, comprising a skin protective ingredient, a therapeutically effective amount of a pharmaceutically active agent comprising an anesthetic agent or derivative thereof, an oleaginous solvent comprising a substance other than the skin protective ingredient, and an aqueous solvent. These skin protectant compositions are capable of temporarily or permanently reducing, inhibiting, treating, ameliorating, or preventing pruritic skin conditions, as well as other related skin conditions. These compositions are further capable of restoring or repairing a skin lipid barrier of a mammal.

The invention provides for a topical o / w emulsion having moisturizing, and protecting, repairing or restoring the skin lipid barrier of the lips of a mammal, and is a topical oil-in-water emulsion composition comprising:(a) a discontinuous oil phase;(b) a continuous aqueous phase comprising water and glycerin, wherein glycerin is present in an amount greater than about 12% w / w;(c) a thickening agent; and(d) at least one lamellar membrane structure; andwherein the composition is a lip protectant composition.

The invention relates to a composition for topical application to the skin comprising effective amounts of a protease inhibitor and a cell differentiation enhancer. The composition is useful in promoting skin lipid barrier repair and maintaining the integrity of the lipid barrier. In this regard, the compositions can be used in the treatment and prevention of dry skin, and associated chrono / proto-aging conditions, in the treatment and prevention of irritation on the skin, in the treatment and prevention of UV-related damage to the skin, and in the enhancement of the retention of self-tanning.

The invention discloses a whitening freckle-removing lipidosome and a preparation method and an application of the whitening freckle-removing lipidosome. A whitening freckle-removing lipidosome composition is prepared from 5-30% of whitening and freckle-removing ingredients, 1-40% of polyhydric alcohol, 1-25% of phospholipid, 1-25% of grease, 1-15% of an emulsifying agent and deionized water. Thewhitening and freckle-removing ingredients comprising various components are screened through a large number of experiments, experiment results show that the provided whitening and freckle-removing ingredients have obvious effects on reducing melanogenesis and the like; the various whitening and freckle-removing ingredients are coated by the lecithin, can much easily permeate into the deep layer of the skin as the structures of the lecithin and the lipid structure of the skin are quite similar, and have the advantage of better skin absorption; the whitening and freckle-removing ingredients coated by the lecithin are isolated from the air, so that the problem of oxidation stain is avoided, and the stability is improved. According to a whitening and freckle-removing product prepared by usingthe lipidosome, the whitening and freckle-removing ingredients are slowly released, and the effects of whitening and removing freckles for a long period of time are achieved.

The present invention relates to methods of topically applying compositions useful in enhancing triglyceride concentration in the lipid barrier of the skin comprising an effective amount of palmitoleic acid, or derivatives thereof, as the sole fatty acid component in combination with a pharmaceutically or cosmetically acceptable carrier. Such compositions are useful in the treatment or prevention of dry skin and conditions in which the skin's lipid barrier is defective or damaged.

Provided are an emulsion composition containing a nanosized (10 to lOOOnm) ceramide capsule particle stabilized by doubly encapsulating with wax matrix and polymer, a preparation method of the emulsion composition, and a skin cosmetic composition using the emulsion composition. More particularly, provided is an emulsion composition having superior stability with time in spite of high ceramide content, which is attained by effectively inhibiting gelling between ceramide molecules through trapping ceramide in solid wax matrix and then en not capsulating the wax matrix using polymer. In accordance with the present invention, ceramide, a skin lipid component with excellent moisturizing effect, is prepared into a stable emulsion through being trapped in a nanosized capsule particle, which provides improved dermal delivery and adhesion to skin, and improved and long-lasting moisturizing effect.

The invention relates to a water-based delivery system for an active substance, characterized by enhancing skin barrier restoration in the stratum corneum comprising water, a fatty acid, cholesterol, a ceramide and at least one skin lipid precursor.

The invention discloses a skin moisturizer, and aims to provide a phytosphingosine skin moisturizer. The technical scheme is characterized in that the phytosphingosine skin moisturizer is prepared from the following components in parts by weight: 10-12 parts of phytosphingosine, 8-10 parts of ceramide, 5-7 parts of cholesterol, 8-11 parts of hydrogenated lecithin, 14-17 parts of phosphoric acid component, 22-24 parts of nutrient component and 60-80 parts of deionized water. The phytosphingosine skin moisturizer has the advantages that the effects of repairing cells and moistening are achieved by adding the phytosphingosine and the ceramide; moreover, phospholipid having a structure similar to that of skin lipid is added, so that the skin permeability of the phytosphingosine and the ceramide is improved; furthermore, a nano-liposome is prepared by adding the cholesterol and the hydrogenated lecithin, so that the affinity of the phytosphingosine and the ceramide to oil phases is improved, and a good absorption effect is achieved.

The invention relates to an anti-irritation composition and an application thereof. The anti-irritation composition comprises a peach gum extract and a cactus extract. The anti-irritation composition disclosed by the invention has a remarkable effect of antagonizing irritation of a surfactant. The efficacy evaluation experiments prove that the anti-irritation composition has an obvious inhibiting effect on erythrocyte hemolysis caused by the surfactant, the irritation to chick chorioallantoic membrane caused by the surfactant is obviously reduced, skin texture damage caused by the surfactant can be effectively improved, the skin lipid arrangement disorder caused by the surfactant is obviously improved, and the adverse reaction of different surfactants on the human skin is obviously reduced.

The invention relates to a water-based delivery system for an active substance, characterized by enhancing skin barrier restoration in the stratum corneum comprising water, a fatty acid, cholesterol, a ceramide and at least one skin lipid precursor.

The invention discloses a culture fluid that promotes the generation of a lipid structure of tissue engineered skin. A basic culture fluid is added with hydrocortisone, epidermal growth factors, isoproterenol, insulin, transferrin, triiodothyronine, adenine, vitamin C, tretinoin, cholera toxin, L-serine, L-novain, palmic acid, linoleic acid, arachidonic acid, bovine pituitary extract, bovine serum albumin, calcium chloride, penicillin, streptomycin and fungizone B, etc. Tissue engineered skin with mature and completely differentiated horny layer and good lipid structure can be obtained by cultivating keratinocyte in the culture fluid of the invention, the culture fluid has strong stability, long shelf life of about 12 months, simple and convenient preparation method, and convenient product synthesis and mass production.

A unique delivery method for providing optimal pH in topical skin formulations is described. Cosmetically acceptable skin formulations prepared with selected weak acids neutralized with ammonia will gradually increase in acidity after topical application. The initial neutral pH changes to a pH compatible with normal skin processes important for skin lipid barrier renewal and sloughing of cells from the stratum corneum.

The invention discloses a composition and cosmetics with moisturizing and repairing effects, and relates to the technical field of cosmetics. The composition is composed of the following components in parts by weight: 1 to 10 parts of a bifidus yeast fermentation product lysate; 0.1 to 5 parts of glycosylglycerol; 0.1 to 10 parts of egg yolk oil; and 0.01 to 5 parts of a moisturizing complex; wherein the moisturizing complex comprises ceramide NP, ceramide AP, phytosphingosine, cholesterol, ceramide EOP and an additive. According to the composition, specific raw materials are selected for compounding, the bifidus yeast fermentation product lysate helps epidermis cells and dermal cells to resist harmful effects of UVB rays and maintain cell integrity and vitality, glycosylglycerol and egg yolk oil can enhance the vitality and metabolism of the cells, the moisturizing complex can remodel a skin lipid barrier while providing a moisturizing effect, and the components have a synergistic effect, so that effects of moisturizing and repairing skin can be achieved.

The invention relates to a water-based delivery system for an active substance, characterized by enhancing skin barrier restoration in the stratum corneum comprising water, a fatty acid, cholesterol, a ceramide and at least one skin lipid precursor.

The invention discloses a multi-dimensional barrier repair composition. The composition comprises a functional compound, an osmotic equilibrium agent and a solvent; the functional compound comprises a functional component A which is a component capable of promoting keratinization envelope and tight junction protein expression, a functional component B which is a component capable of improving the self-moisturizing power of the skin, a functional component C which is a component capable of activating a PPAR receptor and strengthening a skin lipid barrier, a functional component D which is a component capable of regulating an immune barrier and relieving skin inflammation, and a functional component E which is a component capable of balancing the microecology of the epidermis; the osmotic equilibrium agent comprises one or more of lecithin and / or hydrogenated lecithin, maintains all the functional components to safely and effectively permeate to different sites of the skin barrier, and is an important component for enabling the composition to play a role; and the solvent comprises deionized water and an organic solvent. The invention also discloses a preparation method of the multi-dimensional barrier repair composition. The multi-dimensional barrier repair composition is capable of realizing effective co-dissolution of the functional compound, the osmotic equilibrium agent and the solvent in the composition.

The invention discloses natural skin activating essence and a preparation method thereof. The natural skin activating essence is characterized by being prepared from the following raw materials in parts by weight: a component A: 10 to 15 parts of a seaweed extracting solution, 2 to 3 parts of allantoin, 6 to 8 parts of glycerinum, 1.2 to 1.5 parts of xanthan gum and 50 parts of deionized water; a component B: 8 to 10 parts of a Nuphar pumilum (Hoffm.) DC. extracting solution, 2 to 3 parts of glyceryl stearate, 1.2 to 1.4 parts of methylparaben, 0.6 to 0.8 part of carbomer 941, 2 to 4 parts of polydimethylsiloxane, 0.5 to 0.7 part of panthenol, 0.08 to 0.1 part of essential oil and 0.06 to 0.08 part of ethylene diamine tetraacetic acid; and a component C: 8 to 10 parts of a water nymph extracting solution, 3 to 5 parts of hyaluronic acid, 1 to 2 parts of squalane, 0.5 to 0.7 part of nicotinamide and 0.1 to 0.3 part of a preservative. Active components in a water-based plant have the effects of delaying senescence and maintaining moisture; the seaweed extracting solution can suppress peroxidation of skin lipid and delay skin senescence; the Nuphar pumilum (Hoffm.) DC. extracting solution has a good effect of suppressing tyrosinase and can inhibit formation of melanin; and the water nymph extracting solution and the nicotinamide work cooperatively and have a deep water locking effect and a good moisture maintaining effect.

The invention discloses a mild and allergy-relieving amino acid cleansing milk and a preparation method thereof. All components in the formula of the cleansing milk are synergistically matched with each other, mild and allergy-relieving effects are reached, a relatively mild amino acid surface active agent is used as a foaming cleanser, the skin can be cleaned effectively, and stimulation on skin and damage on skin lipid membranes also can be reduced; an avocado fat extract, ubiquinone, nicotinamide, sorbitol and glycerol are further additionally added, and whitening and moistening maintenance for skin is increased; three plant origin ingredients, such as p-hydroxy phenyl ethyl ketone, caprylhydroxamic acid and ethylhexylglycerin, are compounded for protecting the stability of a paste body, and moreover, the mild and allergy-relieving amino acid cleansing milk has excellent anti-microbial and antibacterial performances; the cleansing milk is further added with a purslane extract as a plant allergy-relieving agent, the sensitivity of sensitive skin crowds, such as people with hormone faces, for the cleansing milk is reduced to the maximum extent, the irritation is reduced, and the cleansing milk is milder and more applicable for more crowds to use.

The invention discloses a phytosterol composition for cosmetics. The phytosterol composition for cosmetics consists of the following raw materials in parts by weight: 1 part of behenyl alcohol, 1-5 parts of cetyl alcohol, 1-5 parts of phytosterol and 0.1-10 parts of phytosteryl ester. According to the phytosterol composition, cholesterol and cholesteryl ester in skin lipid are simulated, phytosterol and phytosteryl ester are used as active ingredients, cetyl alcohol and behenyl alcohol are carefully selected to improve the solubility and melting point of a system, and the phytosterol composition is obtained through a better weight part ratio. The problem that in the prior art, phytosterol and phytosteryl ester are added at the same time and are poor in intersolubility is solved, and meanwhile the obtained composition is good in oil solubility, low in melting point, high in operability in a cosmetic formula and beneficial to industrial application of phytosterol. The obtained additive is applied to cosmetics, the skin care characteristic of phytosterol can be effectively exerted, and the skin friendliness of the product can be improved.

The invention discloses a high-efficiency whitening freckle-removing cream with an antiallergic function. The high-efficiency whitening freckle-removing cream is prepared from, by weight, 5%-30% of active ingredient extracts, 2%-10% of vitamin C, 0.5%-3% of arbutin, 3%-8% of notoginsenoside, 1%-4% of nicotinamide, 0.5%-2% of astaxanthin, 2%-3% of natural propolis extracts, 1%-2% of squalane, 3%-5%of grease, 3%-15% of humectant and 10%-85% of deionized water. Accordingly, the main raw materials are the active ingredient extracts, the vitamin C, the arbutin, the nicotinamide, the astaxanthin, the natural propolis extracts, the squalane, the grease and the humectant; the squalane can enhance epidermis repair, effectively form a natural protection film and help the balance between the skin and sebum, the squalane also can inhibit peroxidating of skin lipid, schizonepetae herba can promote skin blood circulation strengthening, has the slight antipyresis and analgesia effects and can promote healing of skin infectious diseases and absorption of lesion tissue, and the effects of relieving itching and resisting allergy are achieved; no side effect exists, and convenience is brought to use.

The invention discloses a method for preparing skin care compositions applicable to sensitive skin on the basis of skin lipidomics. The method includes analyzing different lipid of skin of sensitive skin population and healthy skin population; adding single components or compound components with appropriate proportions into skin care products according to screened different lipid to obtain the skin care compositions applicable to relieving skin allergy symptoms. The method has the advantages that skin barrier effects can be improved by the skin care compositions prepared by the aid of the method, the skin allergy symptoms can be relieved by the skin care compositions, the skin care compositions are free of skin irritation and can be well received by extensive consumers, and accordingly themethod has an excellent application prospect.

The invention provides for a topical o / w emulsion having moisturizing, and protecting, repairing or restoring the skin lipid barrier of the lips of a mammal, and is a topical oil-in- water emulsion composition comprising: (a) a discontinuous oil phase; (b) a continuous aqueous phase comprising water and glycerin, wherein glycerin is present in an amount greater than about 12% w / w; (c) a thickening agent; and (d) at least one lamellar membrane structure; and wherein the composition is a lip protectant composition.

The invention relates to a water-based delivery system for an active substance, characterized by enhancing skin barrier restoration in the stratum corneum comprising water, a fatty acid, cholesterol, a ceramide and at least one skin lipid precursor.

The invention provides a radioresistant xylitol, which uses xylitol as a main component and comprises 55% of xylitol, 20% of spirulina, 14.5% of dried strawberry and 0.5% of calcium disodium edetate. After preparation according to a weight ratio, the spirulina, dried strawberry and calcium disodium edetate are mixed and crushed into particles lager than 120 mesh; then thawing xylitol is uniformly mixed to be prepared into particles. A large amount of vitamin E and polyphenol antioxidant substances contained in the spirulina and dried strawberry can defend high intensity radiation, alleviate skin damages caused by ultraviolet radiation, such as skin lipid oxidation, drying and erythema; and the calcium disodium edetate can expel lead to avoid secondary poisoning during radiation prevention.