18 results about "Skin lipid" patented technology

The invention belongs to the technical field of exosome freeze-dried powder, and discloses exosome freeze-dried powder and a preparation method thereof, the exosome freeze-dried powder contains mesenchymal stem cell exosome, trehalose, sodium hyaluronate, hydroxypropyl-beta-cyclodextrin, glutathione, ceramide and fructo-oligosaccharide. According to the exosome freeze-dried powder, hydroxypropyl-beta-cyclodextrin, glutathione, ceramide and fructo-oligosaccharide are added, the membrane structure integrity of the exosome is effectively protected, the retention rate of active substances in the exosome freeze-dried powder is high, and therefore the effects of resisting inflammation, regulating cell metabolism, promoting tissue repair and the like of the exosome can be fully exerted. In addition, glutathione can directly remove skin free radicals and inhibit oxidative stress injury, and has an anti-oxidation effect; ceramide can also supplement skin lipid barrier, enhance the water locking capacity and enhance the moisturizing effect of sodium hyaluronate; fructo-oligosaccharide can also regulate skin micro-ecological balance, and has anti-inflammatory and bacteriostatic effects.

The application belongs to the technical field of microorganisms and particularly relates to a Bifidobacterium adolescentis beneficial to skin, a derivative of the Bifidobacterium adolescentis and application of the Bifidobacterium adolescentis and the derivative. The derivative of the Bifidobacterium adolescentis has significant antioxidant and anti-inflammatory effects, can inhibit pathogenic bacteria of acne and other common skin infections such as Propionibacterium acnes, Staphylococcus aureus and Malassezia furfur, can eliminate pathogenic bacteria, can inhibit skin lipid accumulation, can avoid follicle blockage, and can improve skin problems in multiple directions, especially acne skin problems.

The invention discloses a sebum-imitated recombinant collagen anti-oxidation anti-aging brightening composition and a preparation method thereof, the sebum-imitated recombinant collagen anti-oxidation anti-aging brightening composition is of a core-shell double-phase structure, and the sebum-imitated recombinant collagen anti-oxidation anti-aging brightening composition comprises an aqueous phase core, an aqueous phase core and a composite material, the active ingredient of the aqueous phase core is a covalent bond of carboxymethylated recombinant human collagen III and eclipta oligopeptide; the oil-phase layer wraps the water-phase core and comprises a sebum-imitating three-phase film as well as an antioxidant active matter and a slow-release carrier which are dispersed in the sebum-imitating three-phase film; wherein the volume ratio of the water-phase core to the oil-phase layer is 1: 2-1: 4, a core-shell double-phase structure with the carboxymethylated recombinant collagen-eclipta oligopeptide covalent bond as the water-phase core and the sebum-imitating three-phase membrane functional carrier as the oil-phase layer is constructed, and the limitation that active ingredients in a traditional formula are simply mixed is broken through. According to the structure, the stability of the water phase core is ensured through a chemical covalent bond, and the percutaneous permeability and biocompatibility of the composition are remarkably improved by utilizing the high similarity of a sebum-imitating film and skin lipid.

The invention discloses a skin care moisturizer preparation method, which comprises: S1, heating an oil phase component to a molten state under a vacuum condition to obtain a homogeneous oil phase; s2, mixing and swelling a water phase component containing a macromolecular thickening agent under a heating condition to obtain a homogeneous water phase; s3, mixing the water phase and the oil phase under a vacuum condition, shearing and homogenizing at 70-80 DEG C to form a primary emulsion, and then starting to cool; s4, when the temperature of the system is reduced to a first preset temperature interval, adding a first group of active substances and uniformly dispersing; and S5, when the temperature of the system is continuously reduced to a second preset temperature interval, adding a second group of active substances, uniformly dispersing, and then adjusting the pH value of the system to 5.5-6.0. According to the present invention, the ceramide, the recombinant collagen and the decarboxylated carnosine are adopted, and the ceramide and the squalane are adopted to simulate the skin lipid so as to actively repair the barrier;

The application discloses a plant extract for reducing oil secretion, which comprises 5-25 parts of citrus by weight, 3-15 parts of sophora, 3-15 parts of compositae, 3-15 parts of seaweed plant and 1-10 parts of camellia by weight; and the preparation raw material further comprises a solvent. The grapefruit, sophora and dandelion are combined to inhibit 5alpha-reductase activity from the source, inhibit sebaceous gland cell activity and reduce skin oil secretion. The large leaf seaweed and green tea are combined to have good antioxidant effect, can relieve the irritation of peroxide squalene to the skin caused by skin lipid oxidation, and avoid inflammation; meanwhile, the moisturizing component contained can reduce skin water loss, avoid excessive oil secretion caused by dry skin, and solve the problems that the existing oil control skin care and color cosmetic products cannot fundamentally solve oil secretion, have obvious side effects, have insufficient effect, and are prone to recurrence.

The invention relates to a quaternary lipid barrier repairing composition which is prepared from the following raw materials: tea-seed oil, camellia-seed oil, a phytosterol derivative and meadowfoam seed oil. Through compounding of the tea-seed oil, the camellia-seed oil, the phytosterol derivative and the meadowfoam seed oil, multi-dimensional barrier repair synergy of passive supplement, active repair and antioxidant protection is realized. The quaternary lipid system is highly similar to a human body sebum membrane structure, and can rapidly fill up cuticle lipid gaps, significantly reduce transdermal moisture loss and efficiently repair a skin physical barrier; the phytosterol derivative can be cooperated with the tea-seed oil and the camellia-seed oil, lipid components can be directly supplemented, a skin lipid synthesis mechanism can be activated, skin endogenous generation proportion-coordinated cholesterol-ceramide-free fatty acid is guided, and self-reconstruction of a barrier is achieved; the meadowfoam seed oil has excellent oxidation resistance, so that secondary damage of oxidative stress to lipid can be effectively resisted, and the stability and durability of repair are ensured.

This invention relates to a method for preparing verbascoside and its application in promoting skin lipid production, belonging to the technical field of skin care and topical products. The method includes the following steps: Selecting dried fleshy stems of *Cistanche deserticola*, *Cistanche tubulosa*, *Cistanche salsa*, and *Cistanche salsa* (all belonging to the Orobanchaceae family), pulverizing them after pretreatment, and extracting them with 50%-80% ethanol aqueous solution under reflux for 2-4 times, 1-3 hours each time. The extracts are combined and concentrated under reduced pressure until no alcohol odor remains, obtaining a concentrated solution. The concentrated solution is passed through an AB-8 macroporous adsorption resin column, eluted sequentially with deionized water and 30%-50% ethanol aqueous solution to remove impurities, and then eluted with 60%-90% ethanol aqueous solution to remove the target component. The eluent is collected and concentrated under reduced pressure, purified by silica gel column chromatography using chloroform-methanol at a volume ratio of 5:1-2:1 as the eluent. The target fraction is collected, concentrated under reduced pressure, and freeze-dried to obtain the purified verbascoside. The beneficial effects of this invention are: verbascoside has a skin-protective effect and exhibits superior skin-care activity when applied to products.

The invention discloses a composition for repairing a tough skin barrier of sensitive skin and a preparation method and application thereof, the composition for repairing the tough skin barrier of the sensitive skin comprises bisabolol, a ginger root extract and ceramide, and the mass ratio of the bisabolol to the ginger root extract to the ceramide is (0.001-5): (0.0001-1): (0.001-5). The bisabolol has anti-inflammatory and soothing effects; the ginger root extract has natural oxidation resistance and can help relieve damage of the external environment to the skin; ceramide can effectively supplement skin lipid and repair a damaged barrier structure. Under the synergistic effect of the bisabolol, the ginger root extract and the ceramide, uncomfortable symptoms such as redness and pruritus of sensitive skin can be quickly relieved, meanwhile, the skin barrier function is fundamentally enhanced, the skin tolerance and the water retention capacity are improved, and the composition can be applied to cosmetics as a composition for repairing the sensitive skin and strengthening the skin barrier.

The invention discloses a cleaning composition based on a camellia oil acyl glycine surfactant, the cleaning composition comprises a skin cleaning agent and camellia oil acyl glycine, the camellia oil acyl glycine and the skin cleaning agent form the cleaning composition with a selective cleaning function, and the cleaning composition acts on skin and has unique mild cleaning performance. According to the present invention, the skin lipid removing effect of the cleaning product can be effectively reduced, and the cleaning power on the basic makeup and other skin dirt can be maintained so as to furthest reduce the skin damage during the cleaning process, and effectively improve the mildness of the product.

The invention discloses an anti-alopecia emulsion and a production process thereof, and relates to the technical field of daily chemical products, in order to improve the anti-alopecia effect of the shampoo, a bacteriostatic agent component is prepared and added, and the combination of a bacteriostatic agent and skin lipid is effectively improved in a manner of generating a silane long chain segment in the bacteriostatic agent component, so that the anti-alopecia effect of the shampoo is improved, and the anti-alopecia effect of the shampoo is improved. The active substances can enter the hair follicles conveniently, so that the activity of malassezia is inhibited, the active substances can be prevented from being taken away by flowing water during washing by combining with lipid, and the active substances can be retained on the skin surface for a long time to inhibit the reproduction of malassezia; the thiophene ring, the pyridine ring, the halamine group and other structures have excellent antibacterial activity and can inhibit fungal proliferation activity, so that the antibacterial effect on malassezia is effectively improved, and the problem of alopecia caused by malassezia reproduction is avoided.

The present application belongs to the field of polypeptide drug preparation, and particularly relates to a kind of short peptide dimer and its nanocomposite.The tripeptide (Ser-Cys-Arg) is assembled to form short peptide dimer by hydrogen bond in aqueous solution, which first discloses that short peptide forms cyclic dimer structure through intermolecular hydrogen bond, without using chemical crosslinking agent, oxidizing agent or protection / deprotection step, and the process is more simple and mild, and more suitable for synergistic assembly with drug molecules to form nanocomposite.The short peptide dimer provided by the present application can efficiently encapsulate model drugs to form "peptide-drug" nanocomposite, which can diffuse in gel matrix to epidermis, form multiple non-covalent interactions with skin lipids and keratin, significantly improve the transdermal permeability of drugs through dual pathways of cell penetration and intercellular gap transport, and reach the action site to realize efficient targeted drug release.

The present application relates to a plant extract-based liposoluble antioxidant and skin lightening composition and its skin care product. The plant extract-based liposoluble antioxidant and skin lightening composition comprises the following components by mass fraction: 5-50 of deep sea fish oil, 0.05-2 of tomato fruit extract & jojoba seed oil & squalane compound, and 0.05-1 of jojoba seed extract & olive fruit oil compound. The present application improves the skin lipid content through the synergistic effect of deep sea fish oil, tomato fruit extract & jojoba seed oil & squalane compound, and jojoba seed extract & olive fruit oil compound, resists oxidation in multiple dimensions, removes free radicals, reduces collagen loss, inhibits melanin production, increases skin hyaluronic acid content, enhances the ability of cells to resist oxidation, improves the glossiness and elasticity level of skin cells, and ultimately achieves the effects of antioxidant and overall whitening and skin lightening.

Coconut oil and prunus amygdalus dulcis oil are used as a moistening base, simmondsia chinensis seed oil is matched to enhance the stability of the formula, and pure natural plant essential oil such as angelica sinensis and crocus sativus is compounded, so that muscle tension and aching pain can be directly relieved through the anti-inflammatory and blood-activating effects, and the body soothing effect is achieved. Qi and blood circulation can be promoted, invasion of wind, cold and damp exogenous evil is reduced, and qi stagnation and blood stasis are conditioned from the source; meanwhile, the base oil can supplement skin lipids, repair body surface barriers and provide a stable skin basis for body soothing, essential oil molecules can also act on a neuroendocrine system, relieve emotion pressure and indirectly relieve body tension, a complete closed loop from physiological conditioning and skin care to emotion soothing is finally formed, and the comfortable experience of body and mind synchronization is achieved.

The invention discloses bionic skin lipid and a preparation method thereof. The compound vegetable oil composed of the deep sea fish oil, the camellia seed oil and the prinsepia utilis royle oil is selected, and is rich in triacylglycerol, phytosphingosine, squalene, cholesteryl ester, cholesterol, wax ester, phospholipid and other lipids required by skin; candida lipolytica is adopted to ferment the compound vegetable oil, the bionic skin lipid is obtained after fermentation, the content of effective components and the use feeling are obviously improved, and the bionic skin lipid can be used as an active component to be added into a cosmetic matrix. The multi-dimensional effects of maintaining a skin barrier function, preserving moisture, resisting inflammation, regulating micro-ecology and the like are achieved.

The invention relates to the technical field of cosmetics, and discloses an anti-wrinkle whitening emulsion mask and a preparation method thereof, and space partition loading and pH response slow release of water-soluble and fat-soluble active ingredients are realized by constructing a bicontinuous phase liquid crystal type microemulsion system. According to the mask, the transdermal efficiency, the storage stability and the skin feeling are effectively improved. The contained multi-target active ingredients synergistically exert anti-wrinkle, whitening and barrier repairing effects, and 28-day human body tests show that wrinkles, melanin indexes and skin elasticity are remarkably improved. By accurately designing the bicontinuous phase structure of the liquid crystal type micro-emulsion, spatial isolation and synergistic delivery of the water-soluble anti-wrinkle peptide, the whitening agent and the fat-soluble barrier repairing component are realized, unstable active matters are protected by utilizing a pH partitioning strategy, and the transdermal efficiency and the skin feeling comfort are improved through the molecular matching property of the liquid crystal structure and skin lipid; the core problems of component interference, poor stability, insufficient permeation and the like in the prior art are solved.

The invention belongs to the technical field of preparation of daily necessities, and particularly relates to a moisturizing and soothing composition containing sodium hyaluronate and application of the moisturizing and soothing composition in skin care of infants and children. The hyaluronic acid moisturizing mask is prepared from the following raw materials in parts by mass: 0.01 to 0.05 part of sodium hyaluronate, 5 to 25 parts of a moisturizing component, 0.01 to 0.7 part of a soothing component and 0.1 to 6 parts of a skin moistening component, the moisturizing component is prepared from at least one of glycerol, 1, 3-butanediol and 1, 3-propylene glycol; the soothing component is prepared from at least one of allantoin, bisabolol and a radix gentianae extract; the skin moistening component comprises shea butter and / or hydrogenated coconut oil. After the sodium hyaluronate is added, the composition can promote the metabolism of cuticle cells and assist in barrier repair; after the moisturizing component and the relieving component are compounded, the composition can directly supplement skin lipid, form a protective layer, inhibit release of inflammatory factors and relieve redness and stabbing caused by barrier damage, and is suitable for delicate skin of infants and children.

The invention relates to a whitening composition, modified glutathione and a preparation method thereof. The preparation method of the modified glutathione specifically comprises the following steps: 1) obtaining a liposome suspension, performing ultrasonic dispersion, mixing the liposome suspension with hyaluronidase and a cross-linking agent, and stirring to obtain a HAase-Lip suspension; and 2) mixing glutathione with the HAase-Lip suspension, carrying out a stirring reaction, and carrying out ultrasonic treatment to obtain the glutathione-Lip composite material. The phospholipid bilayer vesicle structure of Lip can form a physical barrier, so that the efficacy attenuation is greatly delayed. Meanwhile, a skin-like lipid structure of Lip can be fused with a cuticle lipid bilayer, the nanoscale particle size of Lip can be matched with the cuticle gap size, and Lip penetrates through the cuticle by means of the permeation mechanism of Lip; on the other hand, HAase has the capability of degrading hyaluronic acid on the surface layer of the skin, assists Lip and internal GSH to permeate into the deep layer of the epidermis, and reduces the damage of transdermal penetration to the skin barrier.

The invention discloses a safe and efficient transdermal natural collagen liposome, a preparation method and an anti-skin aging application thereof, and belongs to the technical field of biology. The collagen liposome is formed by wrapping natural collagen into a safe and stable liposome internal water phase, a safer stabilizer is innovatively used for replacing a traditional stabilizer cholesterol, and the stabilizer is covalently grafted with a polyethylene glycol chain, so that the basic function of the collagen liposome as a phospholipid membrane stabilizer can be effectively achieved; in addition, PEGylated phospholipid which is additionally added for endowing the long-cycle characteristic in a traditional nano preparation can be synchronously replaced, so that the formula composition of the whole system is simplified, and uncontrollable factors and potential complexity which are introduced by various auxiliary materials are reduced. The safe and efficient transdermal natural collagen liposome prepared by the invention can remarkably improve skin wrinkles and skin elasticity in a photoaging model, relieve skin lipid peroxidation and promote collagen regeneration, and can be applied to preparation of materials in the fields of cosmetic surgery and dermatology.