Application of alkaloid compounds in the preparation of drugs for inhibiting platelet aggregation
A technology of platelet aggregation and alkaloids, which is applied in the directions of active ingredients of heterocyclic compounds, drug combinations, organic chemistry, etc. Effects of platelet aggregation, full utilization of resources, good medicinal prospects
Active Publication Date: 2022-03-29
GUANGXI ZHUANG AUTONOMOUS REGION ACAD OF AGRI SCI
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Problems solved by technology
In my country's banana production areas, a large number of banana flowers are treated as waste. Due to their high water content and long decay time, they are easy to cause insect pests such as weevils, which will cause secondary pollution of the banana garden environment and waste a lot of plant resources. At this stage not yet fully utilized
[0005] There are no related reports on the application of new alkaloid compounds extracted from banana flowers in the preparation of drugs for inhibiting platelet aggregation
Method used
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Embodiment
[0031] (1) Dry 8 kg of fresh banana flowers in the sun, extract them with ethanol for 3 times, each time for 1 day, combine the extracts, filter, and concentrate under reduced pressure at a vacuum degree of -0.05MPa and a temperature range of 45°C. The final volume after concentration is 15% of the volume of the original solution to obtain an ethanol extract;
[0032] (2) The ethanol extract is dispersed and basically dissolved in water, followed by petroleum ether and ethyl acetate extraction for 3 times respectively to obtain ethyl acetate extract;
[0033] (3) dissolving the ethanol ethyl ester extract in methanol, adding 100 meshes of 2 times the weight of the ethanol ethyl ester extract to mix the sample, after the solvent evaporates to dryness, eluting through the silica gel chromatographic column of methanol, Carry out gradient elution through the silica gel chromatographic column of chloroform-methanol again by described gradient eluent, the gradient elution of silica ...
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The invention belongs to the technical field of the application of active compounds for inhibiting platelet aggregation, and in particular relates to the application of alkaloid compounds extracted from banana flowers in the preparation of drugs for inhibiting platelet aggregation. The present invention uses banana flowers as raw materials to extract alkaloid compounds, which can turn waste into treasure, make full use of resources, and increase the economic value of the banana planting industry, and the extracted alkaloid compounds have better activity of inhibiting platelet aggregation. Antiplatelet drugs provide more options for the treatment of thrombotic diseases.
Description
technical field [0001] The invention belongs to the technical field of the application of active compounds for inhibiting platelet aggregation, and in particular relates to the application of alkaloid compounds in the preparation of drugs for inhibiting platelet aggregation. Background technique [0002] Thromboembolism can be found in a variety of organs and tissues, including atrium, ventricle, artery, vein and microvessel. Common complications include: myocardial infarction or angina pectoris caused by coronary artery thrombosis; thrombosis in cerebrovascular disease, that is, stroke; pulmonary infarction caused by pulmonary embolism Or acute pulmonary heart disease; limb arterial embolism causes extremity pain or necrosis; limb venous thrombosis causes local edema and pain; diffuse thrombus occurs in capillaries throughout the body, forming disseminated intravascular coagulation. Thrombosis is a very complex pathological process involving many factors such as platelets, ...
Claims
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IPC IPC(8): A61K31/40A61P7/02C07D207/333
CPCA61K31/40A61P7/02C07D207/333
Inventor 何雪梅唐雅园孙健李丽李昌宝刘国明叶冬青李志春杨莹李杰民周主贵唐杰陈茜郑凤锦辛明易萍
Owner GUANGXI ZHUANG AUTONOMOUS REGION ACAD OF AGRI SCI