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Application of ALDH1L2 in screening, diagnosis and treatment of colorectal cancer of obese subject

A colorectal cancer, subject technology, applied in the field of biomedicine and biological sample detection, to achieve the effect of inhibiting proliferation and migration and improving prognosis

Active Publication Date: 2021-06-01
BINZHOU MEDICAL COLLEGE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, studies have shown that the efficacy of colorectal cancer drugs such as 5-FU can be adversely affected by a high-fat diet or high BMI
[0004] At present, there are no reagents or drugs specifically for the screening, diagnosis, and treatment of colorectal cancer in obese subjects clinically. Therefore, there is an urgent need in this field to develop screening, diagnosis, and effective agent or drug for treatment

Method used

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  • Application of ALDH1L2 in screening, diagnosis and treatment of colorectal cancer of obese subject
  • Application of ALDH1L2 in screening, diagnosis and treatment of colorectal cancer of obese subject
  • Application of ALDH1L2 in screening, diagnosis and treatment of colorectal cancer of obese subject

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Embodiment Construction

[0042] The present invention will be described below with reference to specific examples. Those skilled in the art can understand that these examples are only used to illustrate the present invention and do not limit the scope of the present invention in any way.

[0043] The experimental methods in the following examples are conventional methods unless otherwise specified. The pharmaceutical raw materials and reagent materials used in the following examples are all commercially available products unless otherwise specified.

[0044] As used herein, the term "treatment" encompasses all means of treating a disease or condition in a subject, including inhibiting, alleviating, alleviating, ameliorating, curing one or more symptoms of the disease or condition.

[0045] The present invention specifically provides the application of ALDH1L2 in the preparation of a reagent or kit for the screening, diagnosis, monitoring or prognosis of colorectal cancer in obese subjects. In some e...

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Abstract

The invention provides application of ALDH1L2 in preparation of a reagent or a kit for screening, diagnosis, monitoring or prognosis of colorectal cancer of obese subjects, application of an ALDH1L2 inhibitor in preparation of a medicine for treating the colorectal cancer of the obese subjects. a kit for screening, diagnosis, monitoring or prognosis of colorectal cancer in obese subjects and a pharmaceutical composition for treating colorectal cancer in obese subjects. The ALDH1L2 is introduced into screening, diagnosis and treatment of colorectal cancer of obese subjects, a guidance scheme can be provided for specific and sensitive early diagnosis and precise treatment of colorectal cancer of obese patients, and prognosis of obese colorectal cancer patients is improved.

Description

technical field [0001] The invention belongs to the field of detection of biomedicine and biological samples, and relates to the application of ALDH1L2 in the preparation of reagents or kits for the screening, diagnosis, monitoring or prognosis of colorectal cancer in obese subjects, and the preparation of ALDH1L2 inhibitors Use of a drug for the treatment of colorectal cancer in obese subjects. Background technique [0002] Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract, and its incidence ranks third and second among all tumors affecting men and women, respectively, with 1 to 2 million cases per year With new cases and 600,000 deaths, the number of patients continues to increase. With the development of my country's economy and the changes in the lifestyle of residents, especially the dietary structure, the incidence of CRC in my country has increased more rapidly, especially in urban areas. The etiology of CRC is complex, mainly...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11A61K45/00A61P35/00
CPCC12Q1/6886A61K45/00A61P35/00C12Q2600/118C12Q2600/158
Inventor 田梗姜文国周怡孜米佳杨春华张桂龙
Owner BINZHOU MEDICAL COLLEGE
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