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A kind of ferromagnetic compound of artificial bladder and preparation method thereof

An artificial bladder and composite technology, applied in the field of biomedicine, can solve problems such as the inability to achieve reliable long-term functions, the lack of realistic medical design and biological safety, and the far-reaching difference in human muscle levels.

Active Publication Date: 2022-05-27
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

[0006] This application provides an artificial bladder ferromagnetic compound and its preparation method, which solves or partially solves the problem of the limited hydraulic pressure provided by the artificial detrusor muscle in the prior art, which is far from the human muscle level, lacks realistic medical design and biological The optimization of safety, the technical problem that reliable long-term function cannot be realized; it is realized to provide a ferromagnetic composite that can be used as the actuation source of the magnetically driven soft bladder pump. After the magnetic particles of the ferromagnetic composite are uniformly magnetized, they benefit from permanent High coercive force of magnetic particles and distributed actuation source, ferromagnetism shows reliable actuation while outputting a large amount of magnetic force, acting as an artificial detrusor muscle to squeeze and empty the bladder

Method used

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  • A kind of ferromagnetic compound of artificial bladder and preparation method thereof

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preparation example Construction

[0030] Based on the same invention-creation, see appendix figure 1 , the application also provides a preparation method of an artificial bladder ferromagnetic composite, comprising the following steps:

[0031] S1: Mix the organic silica gel and the polydimethylsiloxane resin uniformly according to the set volume ratio to form an uncured matrix composite compound;

[0032] S2: Add the magnetic particles of the set volume fraction into the uncured matrix compound compound and mix evenly to form an uncured ferromagnetic compound;

[0033] S3: adding a platinum-containing curing agent into the uncured ferromagnetic composite, stirring evenly, and then curing to obtain a cured ferromagnetic composite;

[0034] S4: uniformly magnetize the magnetic particles of the solidified ferromagnetic composite in a pulsed magnetic field with a magnetic induction intensity of 3.0 T to prepare an artificial bladder ferromagnetic composite.

[0035] Further, before curing, a brightener with a w...

Embodiment 1

[0040] The uncured matrix was first prepared by uniformly mixing two silicone-based materials, Ecoflex 00-30 (Smooth-on Inc) with PDMS resin (Sylgard 184, Dow Corning) in a volume ratio of 5:1 using a planetary mixer The compound rubber was kept at 800rpm for 3min, and defoamed for 1min.

[0041]The NdFeB particles with a volume fraction of 25% and an average particle size of 5 μm were uniformly mixed with the uncured matrix composite compound for 2.5 min on a 10-speed gear by a vibrating mixer, and the uncured ferromagnetic composite was prepared by defoaming for 1 min.

[0042] Add 5.5wt% of platinum-containing curing agent to the uncured ferromagnetic composite, stir evenly, and then solidify. The above operations are completed within 30 minutes, and the cured ferromagnetic composite is obtained by curing at 40°C for 5 hours. The magnetic particles in the solidified ferromagnetic composite are uniformly magnetized in a pulsed magnetic field (about 3.0 T) generated by a puls...

Embodiment 2

[0044] The uncured matrix was first prepared by uniformly mixing two silicone based materials, Ecoflex 00-30 (Smooth-on Inc) with PDMS resin (Sylgard 184, Dow Corning) in a volume ratio of 6:1 using a planetary mixer The compound rubber was kept at 800rpm for 3min, and defoamed for 1min. For Ecoflex 00-30 components, the volume ratio of Parts A and B is 1:1.

[0045] Uncured ferromagnetic composites were prepared by uniformly mixing NdFeB particles with a volume fraction of 30% and an average particle size of 5 μm with the uncured matrix compound for 4.5 min on a 10-speed gear by a vibrating mixer, and defoaming for 1 min.

[0046] 7.85wt% platinum-containing curing agent was added to the uncured ferromagnetic composite, and the solidified ferromagnetic composite was obtained by curing at 40°C for 10 h after stirring evenly. The magnetic particles in the solidified ferromagnetic composite are uniformly magnetized in a pulsed magnetic field (about 3.0 T) generated by a pulsed ...

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Abstract

The invention relates to an artificial bladder ferromagnetic compound, which comprises the following components: organic silica gel, polydimethylsiloxane resin, magnetic particles, and the volume ratio of organic silica gel and polydimethylsiloxane resin is (4~ 10): 1. The volume fraction of the magnetic particles in the ferromagnetic composite is 20-40%. The artificial bladder ferromagnetic composite can be used as the actuation source of the magnetically driven soft bladder pump. After the magnetic particles in it are uniformly magnetized, benefiting from the high coercive force of the permanent magnetic particles and the distributed actuation source, the ferromagnetism shows reliable The actuation, while outputting a large amount of magnetic force, acts as an artificial detrusor muscle to squeeze and empty the bladder.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an artificial bladder ferromagnetic composite and a preparation method thereof. Background technique [0002] The rapid development of soft robots for biomedical applications aims to improve medical conditions and provide novel therapeutic tools such as surgical instruments, human simulation and drug delivery. As a class of active systems with high compliance and biocompatibility, soft robots hold great promise in assisting organ movement and even organ reconstruction. Efforts have been made to use soft-bodied robots in prosthetic aids to address various diseased muscles, such as the myocardium, hand muscles, and sphincter. [0003] Hypofunction of the bladder (UAB) is characterized by prolonged urination due to weak muscle contractions, leading to serious complications and even death. UAB has a high incidence due to aging, neurological disorders, trauma, and diabetes, among...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02A61L31/06A61L31/10A61L31/14C09D183/04
CPCA61L31/14A61L31/10A61L31/028A61L31/06C09D183/04A61L2420/04C08L83/04
Inventor 臧剑锋羊佑舟凌青刘继红王少刚吴清扬王佳鑫凌乐杨甲申
Owner HUAZHONG UNIV OF SCI & TECH
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