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An implantable flexible magnetic response artificial bladder substrate and its manufacturing method

An artificial bladder and magnetic matrix technology, applied in the field of biomedicine, can solve the problems of limited hydraulic pressure, human muscle level is far apart, lack of realistic medical design and biological safety, etc., to achieve good biocompatibility, high modulus , high density effect

Active Publication Date: 2022-07-12
武汉磁济科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] This application provides an implantable flexible magnetic response artificial bladder matrix and its manufacturing method, which solves or partially solves the problem of the limited hydraulic pressure provided by the artificial detrusor muscle in the prior art, which is far from the human muscle level and lacks realistic medical design. And the optimization of biological safety, the technical problem of being unable to achieve reliable long-term function; the realization of providing a matrix that can be made into an implantable flexible magnetic response artificial bladder, benefiting from the high coercive force of the permanent magnetic particles in the ferromagnetic composite And distributed actuation source, ferromagnetic shows reliable actuation while outputting a large amount of magnetic force, acting as an artificial detrusor muscle to squeeze and empty the bladder

Method used

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  • An implantable flexible magnetic response artificial bladder substrate and its manufacturing method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The uncured matrix was first prepared by uniformly mixing two silicone-based materials, Ecoflex 00-30 (Smooth-on Inc) with PDMS resin (Sylgard 184, Dow Corning) in a volume ratio of 5:1 using a planetary mixer The compound rubber was kept at 800rpm for 2min, and the foam was removed for 1min. For Ecoflex 00-30 components, the volume ratio of Parts A and B is 1:1.

[0049] The NdFeB particles with a volume fraction of 25% and an average particle size of 5 μm were uniformly mixed with the uncured matrix compound compound for 2 min on a 10-speed gear by a vibrating mixer, and the uncured ferromagnetic composite was prepared by defoaming for 1 min.

[0050] 5.5 wt % of platinum-containing curing agent was added to the uncured ferromagnetic composite, and the curing agent was stirred evenly, and the above operation was completed within 30 minutes. The ferromagnetic composite was obtained by curing at 40 °C for 4 h. The magnetic particles in the ferromagnetic composite are ...

Embodiment 2

[0055] The uncured matrix was first prepared by uniformly mixing two silicone based materials, Ecoflex 00-30 (Smooth-on Inc) with PDMS resin (Sylgard 184, Dow Corning) in a volume ratio of 6:1 using a planetary mixer The compound rubber was kept at 800rpm for 3min, and defoamed for 1min. For Ecoflex 00-30 components, the volume ratio of Parts A and B is 1:1.

[0056] The NdFeB particles with a volume fraction of 30% and an average particle size of 5 μm were uniformly mixed with the uncured matrix composite compound for 4 min on a 10-speed gear by a vibrating mixer, and the uncured ferromagnetic composite was prepared by defoaming for 1 min.

[0057] 7.85wt% of platinum-containing curing agent was added to the uncured ferromagnetic composite, and the curing agent was stirred evenly, and the above operation was completed within 30 minutes. The ferromagnetic composite was obtained by curing at 40 °C for 10 h. The magnetic particles in the ferromagnetic composite are uniformly m...

Embodiment 3

[0062] The uncured matrix was first prepared by uniformly mixing two silicone based materials, Ecoflex 00-30 (Smooth-on Inc) with PDMS resin (Sylgard 184, Dow Corning) in a volume ratio of 9:1 using a planetary mixer For compound rubber, the speed was 1200rpm for 3min, and the foam was removed for 1min. For Ecoflex 00-30 components, the volume ratio of Parts A and B is 1:1.

[0063] The NdFeB particles with a volume fraction of 40% and an average particle size of 5 μm were uniformly mixed with the uncured matrix composite compound for 6 min on a 10-speed gear by a vibrating mixer, and the uncured ferromagnetic composite was prepared by defoaming for 1 min.

[0064] 9.09 wt % of platinum-containing curing agent was added to the uncured ferromagnetic composite, and the curing agent was stirred evenly and then cured. The above operations were completed within 30 minutes. The ferromagnetic composite was obtained by curing at 42 °C for 20 h. The magnetic particles in the ferromag...

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Abstract

The invention relates to an implantable flexible magnetic response artificial bladder base, comprising: a flexible non-magnetic base and a ferromagnetic composite bonded with the flexible non-magnetic base; the flexible non-magnetic base comprises the following components: organic silica gel, polydimethyl Silicone resin, the volume ratio of organic silica gel to polydimethylsiloxane resin is (4-10): 1, and the ferromagnetic composite includes the following components: organic silica gel, polydimethylsiloxane resin, magnetic For the particles, the volume ratio of the organic silica gel to the polydimethylsiloxane resin is (4-10): 1, and the volume fraction of the magnetic particles in the ferromagnetic matrix is ​​20-40%. The implantable flexible magnetically responsive artificial bladder substrate can be fabricated into the substrate of an implantable flexible magnetically responsive artificial bladder, benefiting from the high coercivity and distributed actuation source of the permanent magnetic particles in the ferromagnetic composite, and the ferromagnetic display shows Reliable actuation, while outputting a large amount of magnetic force, acts as an artificial detrusor to squeeze and empty the bladder.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an implantable flexible magnetic response artificial bladder matrix and a manufacturing method thereof. Background technique [0002] The rapid development of soft robots for biomedical applications aims to improve medical conditions and provide novel therapeutic tools such as surgical instruments, human simulation and drug delivery. As a class of active systems with high compliance and biocompatibility, soft robots hold great promise in assisting organ movement and even organ reconstruction. Efforts have been made to use soft-bodied robots in prosthetic aids to address various diseased muscles, such as the myocardium, hand muscles, and sphincter. [0003] Hypofunction of the bladder (UAB) is characterized by prolonged urination due to weak muscle contractions, leading to serious complications and even death. UAB has a high incidence due to aging, neurological disorders, tra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02A61L31/06A61L31/10A61L31/14C09D183/04
CPCA61L31/14A61L31/10A61L31/028A61L31/06C09D183/04A61L2420/04C08L83/04
Inventor 臧剑锋吴清扬凌青羊佑舟王佳鑫凌乐杨甲申
Owner 武汉磁济科技有限公司
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