A kind of artificial bladder ferromagnetic complex and its preparation method

An artificial bladder and composite technology, applied in the field of biomedicine, can solve problems such as limited hydraulic pressure, human muscle levels are far apart, lack of realistic medical design and biological safety, and achieve high modulus and good biocompatibility , high density effect

Active Publication Date: 2021-11-09
TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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AI Technical Summary

Problems solved by technology

[0006] This application provides an artificial bladder ferromagnetic complex and its preparation method, which solves or partially solves the problem of the limited hydraulic pressure provided by the artificial detrusor muscle in the prior art, which is far from the human muscle level, lacks realistic medical design and biological The optimization of safety, the technical problem of not being able to achieve reliable long-term function; the realization of providing a ferromagnetic composite that can be used as an actuation source for magnetically driven soft bladder pumps, benefiting from the high coercive force of the permanent magnetic particles in the ferromagnetic composite And distributed actuation source, ferromagnetic shows reliable actuation while outputting a large amount of magnetic force, acting as an artificial detrusor muscle to squeeze and empty the bladder

Method used

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  • A kind of artificial bladder ferromagnetic complex and its preparation method

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preparation example Construction

[0035] Based on the same invention and creation, see attached figure 1 , the application also provides a method for preparing an artificial bladder ferromagnetic complex, comprising the following steps:

[0036] S1: Mix organic silica gel and polydimethylsiloxane resin evenly according to the set volume ratio to form an uncured matrix composite rubber;

[0037] S2: Add the magnetic particles with a set volume fraction into the uncured matrix composite compound and mix evenly to form an uncured ferromagnetic compound;

[0038] S3: Adding a platinum-containing curing agent into the uncured ferromagnetic composite, stirring evenly, and then curing to obtain a ferromagnetic matrix;

[0039] S4: Mixing organic silica gel with a set volume ratio and brightening agent to obtain an organic silica gel solution;

[0040] S5: Evenly spraying the organic silica gel solution on the surface of the ferromagnetic substrate and then gelling to form a coating;

[0041] S6: After uniformly ma...

Embodiment 1

[0048] The uncured matrix was first prepared by uniformly mixing two silicone-based materials, Ecoflex 00-30 (Smooth-on Inc) and PDMS resin (Sylgard 184, Dow Corning) at a volume ratio of 5:1 using a planetary mixer For compound rubber, mix with a planetary mixer at 800rpm for 2 minutes, and defoam for 1 minute. For Ecoflex 00-30 components, the volume ratio of Part A and Part B is 1:1.

[0049] The uncured ferromagnetic composite was prepared by uniformly mixing NdFeB particles with a volume fraction of 25% and an average particle size of 5 μm with the uncured matrix composite compound on a 10-speed gear with a vibrating mixer for 2 minutes, and defoaming for 1 minute.

[0050] Add 5.5wt% platinum-containing curing agent into the uncured ferromagnetic composite, stir evenly and then cure, and the above operation is completed within 30 minutes. Curing at 40°C for 4 hours to obtain a ferromagnetic matrix. The magnetic particles in the ferromagnetic matrix are uniformly magnet...

Embodiment 2

[0053] The uncured matrix was first prepared by homogeneously mixing two silicone-based materials, Ecoflex 00-30 (Smooth-on Inc) and PDMS resin (Sylgard 184, Dow Corning) at a volume ratio of 6:1 using a planetary mixer Composite rubber, at a speed of 800rpm for 3 minutes, defoaming for 1 minute. For Ecoflex 00-30 components, the volume ratio of Part A and Part B is 1:1.

[0054] The uncured ferromagnetic composite was prepared by uniformly mixing NdFeB particles with a volume fraction of 30% and an average particle size of 5 μm with the uncured matrix composite compound on a 10-speed gear with a vibrating mixer for 4 minutes, and defoaming for 1 minute.

[0055] Add 7.85wt% platinum-containing curing agent into the uncured ferromagnetic composite, stir evenly and then cure, and the above operations are completed within 30 minutes. The ferromagnetic matrix was obtained by curing for 10 h at 40°C. The magnetic particles in the ferromagnetic matrix are uniformly magnetized in ...

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Abstract

The invention relates to an artificial bladder ferromagnetic composite body comprising: a ferromagnetic substrate and a coating coating wrapped on the ferromagnetic substrate; the ferromagnetic substrate includes the following components: organic silica gel, polydimethylsiloxane resin, magnetic Particles, the volume ratio of organic silica gel to polydimethylsiloxane resin is (4-10): 1, and the volume fraction of magnetic particles in the ferromagnetic matrix is ​​20-40%; the coating includes the following components: organic Silica gel and brightener, the mass ratio of organic silica gel to brightener is (1.0~2.0):1. The artificial bladder ferromagnetic composite can be used as the actuation source of the magnetically driven soft bladder pump, benefiting from the high coercive force and distributed actuation source of the permanent magnetic particles in the ferromagnetic composite, the ferromagnetism shows reliable actuation, and at the same time A large amount of magnetic force is output to act as an artificial detrusor muscle to squeeze and empty the bladder.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an artificial bladder ferromagnetic complex and a preparation method thereof. Background technique [0002] The rapid development of soft robots applied in the biomedical field aims to improve medical conditions and provide novel therapeutic tools, such as surgical instruments, human simulation and drug delivery. As a class of highly compliant and biocompatible active systems, soft robots hold great promise in assisting organ movement and even reconstructing organs. Efforts have been made to use soft-bodied robots in prosthetic assistive devices for various diseased muscles such as cardiac muscle, hand muscles, and sphincters. [0003] Underactive bladder (UAB) is characterized by prolonged urination due to weak muscle contraction, leading to serious complications and even death. Affected by age, neurological diseases, trauma and diabetes, the incidence of UAB is high, and m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02A61L31/06A61L31/10A61L31/14C09D183/04
CPCA61L31/028A61L31/06A61L31/10A61L31/14A61L2420/04C09D183/04C08L83/04
Inventor 凌青王佳鑫臧剑锋凌乐杨甲申吴清扬羊佑舟
Owner TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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