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Application of pedf-derived short peptides in tendon healing

A technology for short peptide and tendon injury, which can be used in medical preparations containing active ingredients, drug combinations, peptide/protein components, etc., and can solve problems such as time-consuming amplification process, cost, technology and safety problems and obstacles.

Pending Publication Date: 2021-06-25
BRIM BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cell transplantation requires a time-consuming expansion process
Additionally, cost, technical and safety issues are barriers to delivering patient benefit

Method used

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  • Application of pedf-derived short peptides in tendon healing
  • Application of pedf-derived short peptides in tendon healing
  • Application of pedf-derived short peptides in tendon healing

Examples

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Embodiment Construction

[0013] Embodiments of the present invention relate to methods of treating tendon injuries using PEDF-derived short peptides (PDSP). Human pigment epithelium-derived factor (PEDF) is a secreted protein containing 418 amino acids with a molecular weight of approximately 50 kDa. PEDF is a multifunctional protein with various biological functions (see, eg, US Patent Application Publication No. 2010 / 0047212). Different peptide regions of PEDF were found to be responsible for different functions. For example, a 34-mer fragment (residues 44-77 of PEDF) has been identified as having anti-angiogenic activity, while a 44-mer fragment (residues 78-121 of PEDF) has been identified as having neurotrophic properties.

[0014] The inventors of the present invention found that certain short peptides of PEDF can be used in the treatment of tendon injuries. It was further found that the therapeutic effect may arise from the ability of these PDSPs to induce the expansion of CD146+ TSPCs. CD14...

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Abstract

The invention provides a method for treating a tendon injury includes administering to a subject in need thereof a pharmaceutical composition comprising a PEDF-derived short peptide (PDSP) or a variant of the PDSP, wherein the PDSP comprises residues 93-106 of human pigmented epithelium-derived factor (PEDF), and wherein the variant of the PDSP contains serine-93, alanine-96, glutamine-98, isoleucine-103, isoleucine-104, and arginine 106 of the PDSP and contains one or more amino acid substitutions at other positions, wherein residue location numbers are based on those in the human PEDF.

Description

technical field [0001] The present invention relates to PEDF derived peptides and their use in tendon healing after tendon injury. Background technique [0002] Containing dense connective tissue and transmitting muscle force to bone, tendons are essential for controlling body movement. Tendon injuries are common and usually result from overstretching the tendon. However, tendons are limited in their ability to heal themselves after severe injury due to their lack of blood vessels and acellular nature. Unlike other types of connective tissue, bone marrow stromal stromal cells (BM-MSCs) are difficult to mobilize to tendon injury sites. Therefore, tendon repair is a slow and relatively difficult process. [0003] Recently, considerable efforts have been made to employ cell therapy-based approaches to accelerate tendon regeneration and repair. Adult MSCs are available to provide a sufficient source of cells for tendon regeneration. However, cell transplantation requires a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K38/00A61K38/02A61K38/10A61K38/16A61K38/17
CPCA61K9/0019A61P19/04A61K38/10A61K38/16
Inventor 李文机李元铭曹友平何宗权
Owner BRIM BIOTECH INC