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Antibacterial degradable medical suture

A technology of suture and antibacterial agent, applied in the field of antibacterial and degradable medical suture, can solve the problems of good absorbability and antibacterial performance, unfavorable antibacterial durability wound tissue healing, etc., to achieve the ability to promote tissue healing, high antibacterial and anti-inflammatory activity, The effect of promoting tissue healing

Active Publication Date: 2021-06-29
台州市中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is still not possible to achieve good degradable, absorbable and antibacterial properties, and the sutures are

Method used

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  • Antibacterial degradable medical suture
  • Antibacterial degradable medical suture

Examples

Experimental program
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Effect test

Embodiment 1

[0028] The antibacterial and degradable medical suture thread of this embodiment includes a core thread 1 made of degradable polylactic acid fiber thread and a braided thread layer 2 wrapped around the core thread. The braided thread layer is mainly composed of absorbable suture thread and degradable suture thread. The degradable suture is spun from degradable polylactic acid fiber, and the absorbable suture is mainly made of the following raw materials by weight:

[0029] Collagen: 10; chitosan oligosaccharide: 20; γ-polyglutamic acid: 4.0; seaweed selenium polysaccharide: 1.0; silk fibroin: 3.0; γ-polyglutamic acid loaded with medical antibacterial agent chitosan quaternary ammonium salt , the mass percentage of chitosan quaternary ammonium salt of γ-polyglutamic acid is 2%.

[0030] The specific processing method of the suture thread and the specific spinning processing method can all be conventional processing methods in the art.

Embodiment 2

[0032] The antibacterial and degradable medical suture thread of this embodiment includes a core thread 1 made of degradable polylactic acid fiber thread and a braided thread layer 2 wrapped around the core thread. The braided thread layer is mainly composed of absorbable suture thread and degradable suture thread. The degradable suture is spun from degradable polylactic acid fiber, and the absorbable suture is mainly made of the following raw materials by weight:

[0033] Collagen: 15; Chitosan Oligosaccharide: 18; β-Polyglutamic Acid: 2.0; Dextran Selenite: 0.8; Silk Fibroin: 2.0; The mass percentage of β-polyglutamic acid is 2.5%.

Embodiment 3

[0035] The antibacterial and degradable medical suture thread of this embodiment includes a core thread 1 made of degradable polylactic acid fiber thread and a braided thread layer 2 wrapped around the core thread. The braided thread layer is mainly composed of absorbable suture thread and degradable suture thread. The degradable suture is spun from degradable polylactic acid fiber, and the absorbable suture is mainly made of the following raw materials by weight:

[0036] Collagen: 13; chitosan oligosaccharide: 15; γ-polyglutamic acid: 3.0; arabinoxylan selenite: 0.9; silk fibroin: 2.5; Chitosan quaternary ammonium salt, the mass percentage of chitosan quaternary ammonium salt in γ-polyglutamic acid is 3.0%.

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Abstract

The invention relates to an antibacterial degradable medical suture, and belongs to the technical field of medical biological materials. The problems of poor antibacterial durability and non-absorbability of existing suture are solved. The antibacterial degradable medical suture comprises a degradable core wire and a braided wire layer wrapping the core wire, the braided wire layer is mainly formed by braiding absorbable suture bodies and degradable suture bodies, and the degradable suture line is a polylactic acid fiber line formed by spinning degradable polylactic acid. The absorbable suture line is mainly prepared from the following raw materials in parts by weight: 10-15 parts of collagen, 15-20 parts of chitosan oligosaccharide, 2.0-4.0 parts of an amino acid polymer, 0.8-1.0 part of polysaccharide selenite, and 2.0-3.0 parts of silk fibroin; and the amino acid polymer is loaded with a medical antibacterial agent. The antibacterial degradable medical suture has the advantages of high degradability and absorbability, long antibacterial time and high antibacterial activity, and can be used for promoting healing of wound tissues.

Description

technical field [0001] The invention relates to an antibacterial and degradable medical suture thread, which belongs to the technical field of medical biomaterials. Background technique [0002] Medical surgical suture is the most common medical material used to suture wounds in surgical operations. Although clips, nails, etc. have been continuously developed and applied in recent years, sutures are still the main choice for wound closure in most operations. [0003] Sutures can be divided into absorbable sutures and non-absorbable sutures according to their biodegradability. Absorbable sutures can gradually dissolve with tissues after suturing. This process does not affect the normal healing of wounds and can be degraded into soluble product. Among the existing sutures, there are natural catgut and collagen threads, while the sutures made of synthetic materials include polyvinyl alcohol fibers, polylactic acid fibers, and the like. Non-absorbable sutures do not degrade i...

Claims

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Application Information

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IPC IPC(8): D02G3/44D02G3/22D02G3/04
CPCD02G3/449D02G3/448D02G3/22D02G3/045D10B2331/04D10B2401/13D10B2509/04D10B2401/12
Inventor 瞿向东张玲程娅张优扬
Owner 台州市中心医院
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