Application of Sphondin as effective component in preparation of drugs for treating hepatitis B

A technology for hepatitis B and bovine parsnip, which is applied in the field of biomedicine and can solve problems such as hard-to-yin conversion and hard-to-cure
CN113069445AInactive Publication Date: 2021-07-06CHONGQING MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHONGQING MEDICAL UNIVERSITY
Publication Date
2021-07-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of biological medicines, and particularly discloses application of Sphondin as an effective component in preparation of drugs for treating hepatitis B. It is found for the first time that Sphondin (Sph for short) can inhibit HBsAg secretion by HBV, inhibit the transcriptional level of HBV RNAs, inhibit the replication level of HBV core DNA, inhibit the transcriptional activity of cccDNA and inhibit the levels of HBV RNAs, HBV DNA, HBV S protein and X protein in liver tissue, has an obvious hepatitis B treatment function, and can be used for preparing novel anti-HBV drugs which can reduce the HBsAg level, inhibit cccDNA transcription, and provide wide application prospects in hepatitis B treatment.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to the use of bovine parsnip as an active ingredient in the preparation of hepatitis B therapeutic drugs. Background technique

[0002] Hepatitis B Virus (HBV) is a member of the Hepadnaviridae family. HBV infection is closely related to the occurrence and development of acute and chronic hepatitis, liver cirrhosis and liver cancer. According to statistics, about 2 billion people in the world have been infected with HBV, of which about 350 million people are chronically infected, and about 1 million people die every year from serious diseases such as liver failure, liver cirrhosis and primary hepatocellular carcinoma caused by HBV infection . my country is a high-incidence area of ​​hepatitis B. Although the hepatitis B vaccine has entered the national basic immunization range, it cannot completely eliminate HBV. According to the national hepatitis B serum epidemiological surv...

Claims

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