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A kind of compound pharmaceutical composition and its application

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems that the therapeutic effect of the composition needs to be further improved, and the comprehensive curative effect needs to be improved, so as to achieve the effect of protecting from damage and improving the protective effect

Active Publication Date: 2022-05-27
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Panax notoginseng saponins and ferulic acid have certain curative effects on cardiovascular and cerebrovascular diseases and diabetic complications, their comprehensive curative effect needs to be improved
But the therapeutic effect of the composition prepared by this patent application still needs to be further improved

Method used

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  • A kind of compound pharmaceutical composition and its application
  • A kind of compound pharmaceutical composition and its application
  • A kind of compound pharmaceutical composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A compound pharmaceutical composition, in parts by weight, comprises the following components: 5 parts of Coptis chinensis total alkaloids, 5 parts of Astragalus total saponins and 1 part of Panax notoginseng saponins.

[0045] The preparation method of Coptis Coptidis total alkaloids comprises the following steps: extracting Coptis chinensis coarse powder with 80% (v / v) ethanol of 1 times the amount (solid-to-liquid ratio is 1 g / mL) at 25° C. for 24 hours, and extracting 3 times by the same method. Next, collect the supernatant after extraction, evaporate to dryness under a rotary evaporator, and obtain Coptis chinensis total alkali.

Embodiment 2

[0047] A compound pharmaceutical composition, in parts by weight, comprises the following components: 10 parts of Coptis chinensis total alkaloids, 10 parts of Astragalus total saponins and 3 parts of Panax notoginseng total saponins.

[0048] The preparation method of Coptis Coptidis total alkaloids comprises the following steps: extracting Coptis Coptidis coarse powder with 75% (v / v) ethanol of 1.2 times the amount (solid-liquid ratio is 1:1.2 g / mL) at 30° C. for 30 hours, and using the same Method Extract 4 times, collect the supernatant after extraction, evaporate to dryness under a rotary evaporator, and obtain Coptis chinensis total alkaloids.

Embodiment 3

[0050] A compound pharmaceutical composition, calculated in parts by weight, comprises the following components: 8 parts of Coptis chinensis total alkaloids, 8 parts of astragalus total saponins and 2 parts of Panax notoginseng saponins.

[0051] The preparation method of Coptis Coptidis total alkaloids comprises the following steps: extracting Coptis Coptidis coarse powder with 85% (v / v) ethanol of 0.8 times the amount (solid-liquid ratio is 1:0.8 g / mL) at 20° C. for 20 hours, and using the same Method Extract twice, collect the supernatant after extraction, evaporate to dryness under a rotary evaporator, and obtain Coptis chinensis total alkaloids.

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PUM

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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a compound pharmaceutical composition and application thereof. The compound pharmaceutical composition includes the following components: total alkaloids of Coptidis chinensis, total saponins of astragalus and total saponins of Panax notoginseng. The present invention has the advantages of remarkable effect and small side effects for treating heart, cerebrovascular diseases and diabetic complications.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a compound pharmaceutical composition and application thereof. Background technique [0002] Astragalus is a traditional Chinese medicine that nourishes Qi and solidifies the surface, has a protective effect on the heart, and can improve the immune function of the body. It mainly contains saponins, polysaccharides, in addition to amino acids, flavonoids and other ingredients. Astragalus saponins can improve myocardial contractility, reduce myocardial infarction area, and reduce myocardial damage in acute infarction dogs. Astragalus saponins can effectively improve myocardial ischemia, protect cardiovascular and cerebrovascular, and improve cardiac microcirculation. Its main active ingredient is astragaloside IV. The content of astragalus saponins in the existing astragalus medicinal materials is very low, about 0.04%. The existing Astragalus injection has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P9/00A61P25/00A61P3/10A61P9/10A61P7/02A61P11/00A61P13/12
CPCA61K36/718A61K36/481A61K36/258A61P9/00A61P25/00A61P3/10A61P9/10A61P7/02A61P11/00A61P13/12A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 张晶晶杨洪军周瑞
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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