Bionic kidney organ chip structure and bionic liver and kidney chip structure

A chip structure and chip technology, applied in the fields of bionic kidney organ chip structure and bionic liver and kidney chip structure, can solve the problems of missing organ pharmacokinetic and toxic effects, unable to include liver and kidney communication, etc., and achieve high accuracy Effect

Active Publication Date: 2021-07-27
EAST CHINA UNIV OF SCI & TECH
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, researchers often study liver-on-a-chip and kidney-on-a-chip separately, but lack the operation of combining the metabolic processes of the two bionic organs for r

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bionic kidney organ chip structure and bionic liver and kidney chip structure
  • Bionic kidney organ chip structure and bionic liver and kidney chip structure
  • Bionic kidney organ chip structure and bionic liver and kidney chip structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Such as figure 1 As shown, this embodiment provides a bionic glomerulus chip structure 20, which can simulate the filtering function of glomeruli in human kidney organs. The bionic glomerulus chip structure 20 includes: a top chip 21 , a first filter membrane 210 , a middle chip 22 , a second filter membrane 220 , a bottom chip 23 and the like arranged in order from top to bottom.

[0097] Such as figure 2 and image 3 As shown, the top chip 21 at least includes: a liquid inlet channel 212 , a bionic channel 213 and a liquid outlet channel 214 .

[0098] Wherein, the liquid inlet flow channel 212 is used to receive and deliver functional liquids (for example: incoming liquid, inoculated cell suspension, medicinal liquid, etc.) downstream. The liquid inlet flow channel 212 further includes a first liquid inlet column 241 , a first main flow channel 242 , and a first branch flow channel 243 connected in sequence. The first liquid-introducing column 241 is recessed fr...

Embodiment 2

[0119] Such as Figure 7 , Figure 8 and Figure 9 As shown, the present embodiment provides a bionic kidney tubule chip structure, which includes: a top chip 31, a first porous membrane 310, a middle chip 32, a second porous membrane 320 and a bottom chip arranged in sequence from top to bottom chip33.

[0120] The top chip 31 includes: a liquid inlet channel 311 , a reabsorption chamber 313 , a liquid discharge channel 315 and a liquid discharge column 317 . The liquid inlet channel 311 is used to at least receive the filtrate and deliver the filtrate to the bottom chip 33 . The filtrate can be the filtrate produced by the biomimetic glomerulus chip structure in Example 1. The reabsorption chamber 313 is used to store reabsorbed liquid (abbreviated as reabsorbed liquid). There are three reabsorption chambers 313 in this embodiment, as three parallel control experiments. However, the number of reabsorption chambers 313 may not be limited to three, such as 2, 4 or 5, as ...

Embodiment 3

[0134] This embodiment provides a bionic kidney organ chip structure, which includes: the bionic glomerulus chip structure of Embodiment 1, and the bionic renal tubule chip structure connected in series with the bionic glomerulus chip structure. In the bionic kidney organ-on-a-chip structure, the glomerulus structure can realize the filtering function by utilizing the effective osmotic pressure, and the renal tubule structure can realize the microvilli reabsorption function of the epithelial cells.

[0135] Among them, the bionic glomerulus chip structure is used to filter the incoming liquid to generate filtrate, and the bionic renal tubule chip structure is used to reabsorb the filtrate generated by the bionic glomerulus chip structure to generate reabsorbed fluid.

[0136] In this embodiment, a kidney unit (including glomeruli and renal tubules) is constructed by combining flow channels in a multilayer chip with a multilayer porous membrane. Wherein, the filtering function ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a bionic kidney organ chip structure and a bionic liver and kidney chip structure. According to the bionic kidney organ chip structure, a bionic glomerulus chip structure and a bionic kidney tubule chip structure are combined, so that the filtering function of the glomerulus to related liquid and the re-absorption function of the kidney tubule to filtrate are combined, and the pharmacokinetic characteristics and the detoxification characteristics of the whole kidney organ can be truly and accurately simulated. According to the bionic liver and kidney chip structure, the bionic liver organ chip structure, the bionic kidney organ chip structure and the circulating microstructure are combined, so that the functions of the bionic liver and the bionic kidney are combined, the effect of a single bionic organ can be simulated or detected, the physiological communication between the two bionic organs and the response to the whole circulatory system can be simulated or detected, so that the obtained drug safety evaluation result has high accuracy.

Description

technical field [0001] The invention belongs to the technical field of human bionic organ chips, and in particular relates to a bionic kidney organ chip structure and a bionic liver-kidney chip structure. Background technique [0002] The liver and kidneys are the main detoxification organs in the body. In order to study the detoxification functions of the liver and kidney, bionic liver-on-a-chip and bionic kidney-on-a-chip are often used. However, the structure of the current liver chip is quite different from that of human liver tissue, and it is difficult to simulate the metabolism in the liver more realistically and accurately, which will lead to a large difference between the simulated results and the actual results, which is not conducive to obtaining more accurate pharmacokinetics data of chemical experiments or data of toxicity experiments. The current kidney-on-a-chip suffers from the same problem. In addition, researchers often study liver-on-a-chip and kidney-o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C12M3/06C12M1/12
CPCC12M23/16C12M23/34C12M25/02C12M29/04Y02A50/30
Inventor 张洪波马磊殷瑞雪朱丽丽李洪林黄琪红杨天豪
Owner EAST CHINA UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap