OCT and fluorescence composite microscopic endoscopic imaging system

An imaging system and fluorescence technology, applied in endoscopy, analysis using fluorescence emission, medical science, etc., can solve inconvenient use, image joint diagnosis, inability to realize fluorescence microscopy and OCT in situ microscopic image superimposition, etc. problem, to achieve the effect of overcoming the large size of the probe and facilitating image fusion
CN113180598APending Publication Date: 2021-07-30SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
Publication Date
2021-07-30

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Abstract

The invention discloses an OCT and fluorescence composite microscopic endoscopic imaging system which comprises an OCT module, a fluorescence microscopic module, a microscopic probe and an image processing device, wherein the microscopic probe and the image processing device are shared by the OCT module and the fluorescence microscopic module; the microscopic probe comprises an OCT optical fiber, an OCT imaging objective lens, an MEMS galvanometer, a dichroic prism, a fluorescent microscopic lens and an imaging optical fiber. The optical paths of the OCT module and the fluorescence microscopic module are effectively combined and separated through the microscopic probe, so that the two paths of light can be focused on the same focal plane, OCT imaging and fluorescence imaging can be synchronously carried out on the same area of a sample, and more comprehensive sample information can be obtained; according to the invention, the diameter of the probe sleeve of the integrally-designed microscopic probe can be within 2.8 mm, the probe sleeve can be directly matched with an existing conventional digestive endoscope. Therefore, the defects that in the prior art, an OCT probe and a fluorescent microscopic probe need to be inserted into the sleeve respectively, so that the probe is large in size and inconvenient to use can be overcome.
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Description

technical field

[0001] The invention relates to the technical field of microscopic imaging, in particular to an OCT and fluorescence composite microendoscopic imaging system. Background technique

[0002] Microendoscopic imaging can understand the tissue structure and cell morphology of the tumor in real time. It has a high similarity with the gold standard of pathological diagnosis and can effectively help doctors make intraoperative decisions. It has a tendency to replace frozen sections and biopsies, and has become an and industry research focus. Among them, fluorescence endoscopy and optical coherence tomography (OCT) endoscopy have been popularized in the diagnosis and treatment of early digestive tract cancer due to their unique advantages in superficial microscopy and stereo microscopy. Both techniques are indispensable detection methods in clinical practice, and the combined use can help doctors obtain more abundant tissue microscopic information, which will greatly...

Claims

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