Method for preparing product for targeting tumor stem cells, product and application

Abstract

The invention discloses a method for preparing a product for targeting tumor stem cells, a product and application. According to the application, the product for targeting the tumor stem cells is prepared by taking graphene nanoparticles as a drug loading tool and a targeting tool. According to the product, the tumor stem cells with low cell stiffness can be specifically targeted through the graphene nanoparticles, and anti-cancer drugs are transmitted into the tumor stem cells, so that the aim of specifically eliminating the tumor stem cells is achieved. Targeting is carried out without depending on any surface marker of the tumor cells, so that the problems that in the prior art, nano-drugs targeting the tumor stem cells by depending on tumor stem cell surface protein is difficult for reliably targeting the tumor stem cells and further specifically killing the tumor stem cells due to the influence of the development stage and the type of the tumor.

Description

technical field [0001] The invention relates to the field of nanomaterials, in particular to a method, product and application for preparing a product for targeting tumor stem cells. Background technique [0002] Nanoparticles have shown great potential as carriers of therapeutic drugs in cancer therapy. Currently, cancer stem cell (CSC)-specific surface proteins, such as CD133, CD44, CD90 and aldehyde dehydrogenase, are often used for cancer stem cell labeling, so these specific cancer stem cell surface proteins are used to functionalize cancer stem cell-targeted nanoparticles Surface recognition markers. However, the commonly used surface proteins of cancer stem cells are dynamically evolving, and the surface specific proteins of different types of tumor cells are also different. Therefore, relying on CSC surface proteins may not be able to stably and reliably label CSCs during tumor progression or in different types of tumor cells. In short, the existing nanomedicines ...

AI Technical Summary

Problems solved by technology

However, the commonly used surface proteins of cancer stem cells are dynamically evolving, and the surface specific proteins of different types of tumor cells are also different.

Therefore, relying on CSC surface proteins may not be able to stably and reliably label CSCs during tumor progression or in different types of tumor cells

In short, the existing nano-drugs that rely on tumor stem cell surface proteins to target tumor stem cells are difficult to reliably target tumor stem cells and specifically kill tumor stem cells due to the influence of tumor development stage and tumor type.

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