Cytotoxin T lymphocyte

A lymphocyte and cytotoxic technology, applied in the field of treatment and diagnosis, can solve the problems of backward analysis and research, CTL that is difficult to provide tumor treatment, etc.
CN1379041AInactive Publication Date: 2002-11-13TAKARA HOLDINGS
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TAKARA HOLDINGS
Publication Date
2002-11-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

PURPOSE: Provided are a method and a substance useful for treatment and diagnosis of prostate cancer. Particularly, provided are a peptide having a specific sequence, a mutant thereof and a nucleic acid encoding the same. CONSTITUTION: An HLA-A24- restricted antigen peptide is characterized by being capable of inducing a CTL(cytotoxic lymphocyte) having a T cell receptor specifically recognizing a cell manifesting on the cell surface a complex between the peptide and HLA(human main histocompatibility antigen)-A24 molecule.
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Description

technical field

[0001] The present invention relates to a technique useful in the treatment and diagnosis of diseases caused by abnormal expression of prostate specific membrane antigen (prostate specific membrane antigen, hereinafter abbreviated as PSMA), such as cancer, and specifically, prostate cancer. More specifically, the present invention relates to a compound having a recognizable antigenic peptide and a human major histocompatibility antigen (HLA) molecule useful in the treatment and diagnosis of cancer, specifically prostate cancer and other cancers with abnormal expression of PMSA. Cytotoxic T lymphocytes (cytotoxic T lymphocytes, hereinafter abbreviated as CTL) of the T cell receptor, the antigenic peptide, a CTL inducer useful for inducing the CTL, etc., a method for inducing the CTL, and an anticancer drug useful for the above-mentioned cancer , the detection method of the CTL sensitive cell and its detection reagent, the detection method of the HLA-A24 molecule...

Claims

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