Donkey-hide gelatin plasma substitute and preparation method thereof

Abstract

The invention relates to donkey-hide gelatin plasma substitute and a preparation method thereof. The donkey-hide gelatin plasma substitute is an injection, and donkey-hide gelatin in the donkey-hide gelatin plasma substitute has a molecular weight below 18,000. Through action of biological enzyme, macromolecular gelatin molecules in donkey-hide gelatin are subjected to chemical cutting, so that molecular weight of active ingredients of the donkey-hide gelatin is kept below 18,000, and molecules of the donkey-hide gelatin in the range are faster in a filtering process, so that filtering efficiency is improved, and allergic reaction is eliminated; In addition, transparency and clarity of a solution in the finally prepared injection are improved, and particles and impurities do not exist. In addition, through more than two thousands of repeated animal experiments, namely clinical research, no toxic and side effects, allergic reaction or three carcinogenic toxicity are found. Moreover, the donkey-hide gelatin plasma substitute is safe and effective, and can improve microcirculation, increase blood volume and rapidly increase blood pressure.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method of donkey skin glue injection (plasma replacement), a traditional Chinese medicine emergency medicine in the field of traditional Chinese medicine. Background technique [0002] Artificial plasma or plasma substitutes have experienced more than a hundred years of development history. The earliest understanding of plasma was in the First World War in the last century. A large number of wounded on the battlefield died due to massive blood loss and could not replenish blood in time. At that time, the battlefield medical staff had saved the lives of many wounded by supplementing salt water, but they were still helpless for the wounded who lost too much blood. Later, people found through research that the human body is used to maintain blood volume, keep blood pressure stable, and ensure the supply of nutrition and nutrition in the body. The key to transportation and blood...

AI Technical Summary

Problems solved by technology

[0003] After long-term research, people began to use human plasma, that is, to extract blood from normal people, remove red blood cells and other formed components, keep the plasma part, and make freeze-dried human plasma for future use. Blood sources are in short supply, and due to serious blood pollution, such as AIDS, hepatitis virus, etc., human plasma is extremely unsafe

[0004] In the 1930s, people introduced dextran colloids, which belong to chemically synthesized drugs, which can better replenish blood volume, maintain intravascular osmotic pressure, increase blood pressure, and rescue the wounded in the Second World War, as well as rescue the wounded in hospitals at that time. , large and medium operations, postpartum hemorrhage and other wounded and sick patients have saved a large number of lives, and their contribution is indispensable. However, due to the large molecular weight, it is a chemically synthesized drug with large side effects, great damage to liver and kidney functions, and easy to cause bleeding tendency. and hypoalbuminemia, so the medication is limited, and it was eliminated in the 1970s and 1980s

[0005] In the 1960s and 1970s, the United States and Japan synthesized a