Face filling agent and preparation method thereof
A filler and facial technology, applied in the field of facial fillers and their preparation, can solve the problems of strong inflammatory response, short retention time, large injection volume, etc., and achieve the effect of resisting degradation, no abnormal changes, maintaining fineness and elasticity
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[0030] The present invention also provides a preparation method of a facial filler, comprising the following steps: adding amino acids, stabilizers and excipients into physiological saline for injection according to parts by weight, mixing evenly, and then adding cross-linked hyaluronic acid, collagen polypeptide, Poly-L-lactic acid, thermogelling polysaccharide, recombinant human epidermal growth factor and anesthetic, mixed well to get facial filler.
[0031] In the present invention, amino acids, stabilizers and excipients are added to physiological saline for injection and mixed, so that amino acids are stably dispersed in physiological saline for injection, and then other raw materials are added to prepare the compound with better filling effect and stability simply and conveniently. Good and non-inflammatory facial filler.
Embodiment 1
[0034] A cross-linked hyaluronic acid prepared by the following steps:
[0035] Dissolve 10 g of hyaluronic acid in 80 g of 0.5% sodium hydroxide solution, and stir evenly to obtain a hyaluronic acid solution;
[0036] Add 27g of hydroxyapatite and 5.4g of 1,4-butanediol diglycidyl ether, and stir evenly to obtain the mixed solution 1;
[0037] Heat the mixed solution 1 in a water bath at 40°C for 3 hours to obtain the primary product;
[0038] After the primary product was placed at 15°C for 10 hours, it was dialyzed with deionized water for 2 days, and the dialysate was changed once a day to obtain the finished product.
Embodiment 2
[0040] A cross-linked hyaluronic acid prepared by the following steps:
[0041] Dissolve 15g of hyaluronic acid in 90g of 0.5% sodium hydroxide solution and stir evenly to obtain a hyaluronic acid solution;
[0042] Add 47g of hydroxyapatite and 9.5g of 1,4-butanediol diglycidyl ether, and stir evenly to obtain a mixed solution 1;
[0043] Heat the mixed solution 1 in a water bath at 50°C for 5 hours to obtain the primary product;
[0044] After the primary product was placed at 20°C for 12 hours, it was dialyzed with deionized water for 4 days, and the dialysate was changed twice a day to obtain the finished product.
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