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Face filling agent and preparation method thereof

A filler and facial technology, applied in the field of facial fillers and their preparation, can solve the problems of strong inflammatory response, short retention time, large injection volume, etc., and achieve the effect of resisting degradation, no abnormal changes, maintaining fineness and elasticity

Pending Publication Date: 2021-08-10
易生彬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the existing facial fillers have the following defects: hyaluronic acid is commonly used for injection, but hyaluronic acid is rapidly degraded by hyaluronidase enzymolysis in the body, the retention time is short, the effect is poor, and it needs to be repeated. The filling effect can only be achieved by injection, and the injection volume is too large, which may cause a strong inflammatory reaction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] The present invention also provides a preparation method of a facial filler, comprising the following steps: adding amino acids, stabilizers and excipients into physiological saline for injection according to parts by weight, mixing evenly, and then adding cross-linked hyaluronic acid, collagen polypeptide, Poly-L-lactic acid, thermogelling polysaccharide, recombinant human epidermal growth factor and anesthetic, mixed well to get facial filler.

[0031] In the present invention, amino acids, stabilizers and excipients are added to physiological saline for injection and mixed, so that amino acids are stably dispersed in physiological saline for injection, and then other raw materials are added to prepare the compound with better filling effect and stability simply and conveniently. Good and non-inflammatory facial filler.

Embodiment 1

[0034] A cross-linked hyaluronic acid prepared by the following steps:

[0035] Dissolve 10 g of hyaluronic acid in 80 g of 0.5% sodium hydroxide solution, and stir evenly to obtain a hyaluronic acid solution;

[0036] Add 27g of hydroxyapatite and 5.4g of 1,4-butanediol diglycidyl ether, and stir evenly to obtain the mixed solution 1;

[0037] Heat the mixed solution 1 in a water bath at 40°C for 3 hours to obtain the primary product;

[0038] After the primary product was placed at 15°C for 10 hours, it was dialyzed with deionized water for 2 days, and the dialysate was changed once a day to obtain the finished product.

Embodiment 2

[0040] A cross-linked hyaluronic acid prepared by the following steps:

[0041] Dissolve 15g of hyaluronic acid in 90g of 0.5% sodium hydroxide solution and stir evenly to obtain a hyaluronic acid solution;

[0042] Add 47g of hydroxyapatite and 9.5g of 1,4-butanediol diglycidyl ether, and stir evenly to obtain a mixed solution 1;

[0043] Heat the mixed solution 1 in a water bath at 50°C for 5 hours to obtain the primary product;

[0044] After the primary product was placed at 20°C for 12 hours, it was dialyzed with deionized water for 4 days, and the dialysate was changed twice a day to obtain the finished product.

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PUM

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Abstract

The invention provides a face filling agent and a preparation method thereof, and relates to the technical field of beauty injection. The face filling agent is prepared from the following components in parts by weight: 20 to 45 parts of cross-linked hyaluronic acid, 20 to 40 parts of collagen polypeptide, 15 to 40 parts of L-polylactic acid, 1 to 5 parts of thermal gel polysaccharide, 2 to 5 parts of recombinant human epidermal growth factor, 2 to 10 parts of amino acid, 30 to 70 parts of normal saline for injection, 2 to 8 parts of stabilizer, 10 to 20 parts of excipient and 10 to 30 parts of anesthetic. The preparation method of the face filling agent comprises the following steps: adding the amino acid, the stabilizer and the excipient into the normal saline for injection according to the parts by weight, performing uniform mixing, then adding the cross-linked hyaluronic acid, the collagen polypeptide, the L-polylactic acid, the thermal gel polysaccharide, the recombinant human epidermal growth factor and the anesthetic, and performing uniform mixing to obtain the face filling agent. The face filling agent prepared by the method has the advantages of long retention effect after injection and difficulty in generating inflammatory reaction.

Description

technical field [0001] The invention relates to the technical field of cosmetic injections, in particular to a facial filler and a preparation method thereof. Background technique [0002] Facial soft tissue augmentation is currently one of the minimally invasive treatments for facial volume loss, contour changes, and static wrinkles. The ideal soft tissue filling material should have good biocompatibility, effectiveness and safety. Injecting substances into parts of the human body to achieve the beauty method of correcting skin defects, called injection beauty. Injection cosmetology is a kind of non-surgical plastic surgery. Specifically, it is a large class of plastic surgery that uses injection methods to inject biomaterials or synthetic biocompatible materials into the dermis or subcutaneous layer to reduce skin wrinkles or shape through different mechanisms. The method of surgery. [0003] The commonly used cosmetic injection materials mainly include hyaluronic acid ...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/18A61L27/20A61L27/22A61L27/50A61L27/54A61L27/58
CPCA61L27/20A61L27/24A61L27/18A61L27/227A61L27/50A61L27/58A61L27/54A61L2400/06A61L2430/34A61L2300/414A61L2300/402A61L2300/216C08L5/08C08L5/02C08L89/00C08L67/04
Inventor 易生彬易维
Owner 易生彬
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