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Products and uses for the diagnosis of lung cancer

A product and technology of lung cancer, applied in the field of disease diagnosis, can solve the problems of difficult early detection and lack of specific clinical manifestations of lung cancer

Active Publication Date: 2022-03-08
ZHEJIANG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Early lung cancer is difficult to be detected early due to the lack of specific clinical manifestations

Method used

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  • Products and uses for the diagnosis of lung cancer
  • Products and uses for the diagnosis of lung cancer
  • Products and uses for the diagnosis of lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0069] Example Gene markers associated with lung cancer diagnosis

[0070] 1. Data download

[0071] Lung adenocarcinomas were searched using the Gene Expression Omnibus database GEO (https: / / www.ncbi.nlm.nih.gov / geo / ) and The Cancer Genome Atlas database TCGA (https: / / cancergenome.nih.gov / ) expression profile data. Samples with missing clinical information were excluded, and samples with matched cancer and adjacent tissues were included. TCGA included 59 adjacent samples and 500 lung adenocarcinoma samples; GEO included 20 adjacent samples and 226 lung adenocarcinoma samples. .

[0072] 2. Data processing and analysis

[0073] For datasets in TCGA, RNA-sequencing data of gene expression (FPKM values) and clinical information were downloaded from UCSC Xena (https: / / gdc.xenahubs.net), and FPKM values ​​were converted to kilobases per million (TPM) transcript of the value.

[0074] For the GEO database download the raw "CEL" file of GSE31210, background adjustment and quant...

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Abstract

The invention discloses a product and application for lung cancer diagnosis. Products of the invention include reagents for detecting biomarkers MMP10, POU2AF1, SELE and / or RERGL. The present invention also provides the application of the reagents for detecting biomarkers MMP10, POU2AF1, SELE and / or RERGL in the diagnosis of lung cancer.

Description

technical field [0001] The present invention relates to the field of disease diagnosis, more specifically, the present invention relates to products and applications for lung cancer diagnosis. Background technique [0002] Lung cancer is one of the most common malignant tumors worldwide, and its morbidity and mortality have been on the rise. Although the current treatment methods are improving with each passing day, the morbidity and mortality of lung cancer still rank first in the list of malignant tumors in the world. According to the data of GLOBOCAN in 2018, there are about 2.09 million new lung cancer patients in the world, of which 1.76 million died (Bray F ,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018:GLOBOCANestimates of incidence and mortality worldwide for 36 cancers in 185countries[J].CA:a cancer iournal for clinicians,2018,68(6):394-424.) , the morbidity and mortality both rank first among all malignant tumors. The number of deaths due to lung c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886G01N33/574A61K45/00A61P35/00G16B25/20G16B50/00
CPCC12Q1/6886G01N33/57423G01N33/57484G01N33/57488A61K45/00A61P35/00G16B25/20G16B50/00C12Q2600/158
Inventor 江皓吴稚冰饶远权祝鑫海臧发荣陈国中赖建军陈丽婷
Owner ZHEJIANG HOSPITAL