A dry gel patch for photodynamic therapy of oral precancerous lesions and its preparation method

Abstract

The invention discloses a dry gel patch for photodynamic therapy of oral precancerous lesions and a preparation method thereof, comprising polyacrylic acid, chitosan cationic polymer, photosensitizer, the polyacrylic acid and chitosan The cationic polymer forms a double network gel through chemical crosslinking and electrostatic interaction; the photosensitizer is dispersed in the dry gel patch. The dry gel patch prepared by the method of the present invention has a simple preparation method, and the dry gel patch can be obtained through the steps of polymerization-drying-slicing. The diffusion amount and diffusion ratio of the photosensitizer in the dry gel patch to the precancerous lesions in the oral cavity are regulated by the thickness of the dry gel patch, which can precisely control the dosage and avoid phototoxicity.

Description

A dry gel patch for photodynamic therapy of oral precancerous lesions and its preparation method technical field The invention belongs to the technical field of biomedical materials, be specifically related to a kind of photodynamic therapy for oral cavity precancerous lesions Dry gel patch and preparation method thereof. Background technique Occurrence and progression of oral cancer is a multi-factor, multi-stage, deep-level evolution process, starting from oral precancerous lesions. The research on the occurrence and prognosis of cancer from the perspective of cancer has been more and more widely recognized. Global cases of lip and oral cancer in 2012 alone The number exceeded 300,000, including 145,000 deaths. However, there is a lack of effective treatments for oral precancerous lesions. Even with surgical resection, there is still a high recurrence rate, and it will affect the patient's chewing, pronunciation, swallowing and other functions. [0003] Photody...

AI Technical Summary

Problems solved by technology

However, in clinical practice, this photosensitizer administration method will still be affected by factors such as saliva secretion and tongue movement, which increases the difficulty of the doctor's operation.

And long-term gauze fixation not only increases the patient's discomfort and psychological burden, but also stimulates saliva secretion, dilutes the photosensitizer, and ultimately affects the therapeutic effect

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