Octapeptide and application thereof in preparation of medicine and health care product for improving memory

A technology for improving memory and health care products, applied in applications, medical preparations containing active ingredients, peptides, etc., can solve the problems of being easily degraded by proteases or polypeptide enzymes in the body, low bioavailability, and limited applications, etc., and achieve non-toxicity Effects of side effects, improvement of memory impairment, good safety and practicality
CN113402587AActive Publication Date: 2021-09-17RONGCHENG TAIXIANG FOOD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
RONGCHENG TAIXIANG FOOD
Publication Date
2021-09-17

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Abstract

The invention discloses octapeptide and application thereof in preparation of a medicine and a health-care product for improving memory. The amino acid sequence of the polypeptide is as follows: Trp-Cys-Pro-Phe-Ser-Arg-Ser-Phe (WCPFSRSF). The octapeptide provided by the invention can eliminate sleep deprivation induced mouse dysmnesia, and can significantly inhibit the excitatory toxicity and the oxidative stress of nerve cells. The polypeptide disclosed by the invention can be independently applied to health-care products for improving the memory, also can be compounded with other active ingredients capable of improving the memory and also can be prepared into microcapsules to improve the gastrointestinal digestion stability, the bioavailability and the shelf life of the polypeptide, and therefore, the polypeptide can be more favorably applied to the food industry and the field of health-care products.
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Description

technical field

[0001] The invention relates to an octapeptide and its application in preparing memory-improving medicines and health care products. Background technique

[0002] Glutamate is the major amino acid excitatory neurotransmitter in the brain. When glutamate accumulates too much in the synaptic cleft, the high extracellular concentration of glutamate leads to overstimulation of glutamate receptors, which in turn leads to calcium overload and leads to oxidative stress and apoptosis, which ultimately leads to cell damage and neuron loss, and even trigger neurodegenerative diseases. Conversely, elevated calcium ion flux further exacerbates oxidative stress and accelerates neuronal death, a phenomenon known as excitotoxicity. The excitotoxicity of glutamate is the main cause of neuronal death, which is closely related to a variety of neurological diseases such as Alzheimer's disease and ischemic stroke. Therefore, the neuronal cell model of glutamate damage is ofte...

Claims

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