Btla antibodies

A technology of antibody and human antibody, applied in autoimmune and proliferative diseases and diseases, in the field of treatment of inflammatory and agonistic antibodies, and able to solve problems that have not yet been translated into clinical applications

Pending Publication Date: 2021-09-28
OXFORD UNIV INNOVATION LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Agonist antibodies targeting the human BTLA receptor have been shown to suppress T cell responses ex vivo (see Otsuki et al., Biochem Biophys Res Commun 344:1121-7, 2006; and WO2011 / 014438), but have not yet been translated into clinical use

Method used

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Examples

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Embodiment Construction

[0019] The inventors have identified particularly potent agonist antibodies against BTLA that are expected to be more effective than current antibodies in suppressing T cell responses and thus be particularly useful in the treatment of immune-mediated disorders.

[0020] As used in the specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to "a molecule" optionally includes combinations of two or more such molecules, and the like.

[0021] It should be understood that where the language "comprising" is used herein to describe an aspect, there are also provided other similar aspects described "consisting of" and / or "consisting essentially of".

[0022] It should be understood that one, some or all properties of the various embodiments described herein may apply to any aspect, unless the context clearly dictates otherwise. Furthermore, various embodiment...

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PUM

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Abstract

The invention relates generally to antibodies or antigen binding fragments that bind to human B and T lymphocyte attenuator (BTLA) and uses thereof. More specifically, the invention relates to agonistic antibodies that bind human BTLA and modulate its activity, and their use in treating inflammatory, autoimmune and proliferative diseases and disorders.

Description

[0001] cross reference [0002] This application claims the benefit of UK Application No. 1820554.2, filed 17 December 2018, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates generally to antibodies or antigen-binding fragments that bind to human B and T lymphocyte attenuator (BTLA) and uses thereof. More specifically, the invention relates to agonistic antibodies that bind human BTLA and modulate its activity, and their use in the treatment of inflammatory, autoimmune and proliferative diseases and disorders. Background technique [0004] The immune system must strike a balance between the destruction of pathogens or dangerously mutated cells and the tolerance of healthy self tissues and harmless symbionts. To promote this balance, the activity of immune cells is influenced by the integration of signals from a variety of stimulatory and inhibitory receptors that adapt the cells to their environment. These su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/28
CPCC07K16/2818C07K2317/52C07K2317/33C07K2317/92C07K2317/76A61K2039/505C07K2317/75C07K2317/24C07K2317/34C07K2317/71Y02A50/30A61P29/00A61P37/06A61P1/00C07K2317/51C07K2317/515C07K2317/55C07K2317/565
Inventor 西蒙·约翰·戴维斯理查德·约翰·科纳尔克里斯多佛·道格拉斯·帕卢赫
Owner OXFORD UNIV INNOVATION LTD
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