A calixarene-rhodamine supramolecular co-assembly and its preparation method and application

A co-assembly and supramolecular technology, applied in chemical instruments and methods, analytical materials, measuring devices, etc., can solve problems such as nucleic acid and protein hazards

Active Publication Date: 2022-06-07
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, although iron ions are very active in metabolic processes such as cell metabolism, oxygen transport, and electron transfer, excessive iron ions will cause great harm to nucleic acids and proteins

Method used

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  • A calixarene-rhodamine supramolecular co-assembly and its preparation method and application
  • A calixarene-rhodamine supramolecular co-assembly and its preparation method and application
  • A calixarene-rhodamine supramolecular co-assembly and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Preparation of calixarene-rhodamine co-assembly:

[0045] a. Mix rhodamine (50mg, 0.104mmol) and 4-sulfonylcalix[4]arene hydrate (225mg, 0.302mmol) into a hydrochloric acid solution (6mol / L, 15mL), stir to dissolve, and obtain solution A ;

[0046] b. Transfer solution A to a stainless steel autoclave lined with 25 mL of Teflon, hold it at a constant temperature of 100°C for 1 hour, then cool it to room temperature, transfer it to a beaker, and let it stand at room temperature for 2 days , to obtain crystal B;

[0047] c. Use the Bruker D8 VENTURE single crystal diffractometer to test the structure of crystal B to determine its molecular configuration and molecular formula. The molecular configuration is a solid triangular structure and the molecular formula is C. 112 H 103 O 51 N 2 S 12 Cl, molecular weight is 2713.17;

[0048] d. Determination of crystal B 1 H NMR spectrum, to further determine the ratio of calixarene-rhodamine co-assembly, the rati...

Embodiment 2

[0050] Example 2: Preparation of calixarene-rhodamine co-assembly:

[0051] 1) rhodamine and 4-sulfonylcalix[4] arene hydrate are mixed in a hydrochloric acid solution with a concentration of 6 mol / L in a ratio of less than 1:5, and stirred to dissolve to obtain solution A;

[0052] 2) Add solution A to the autoclave, keep it at a constant temperature for 1.5h under the heating condition of 95°C, then cool it to room temperature, and stand for 1d to crystallize to obtain crystal B;

[0053] 3) Filter out the crystal B described in step 2). The crystal B is the calixarene-rhodamine supramolecular co-assembly.

Embodiment 3

[0054] Example 3: Preparation of calixarene-rhodamine co-assembly:

[0055] 1) rhodamine and 4-sulfonylcalix[4] arene hydrate are mixed in a hydrochloric acid solution with a concentration of 6 mol / L in a ratio of less than 1:7, and stirred to dissolve to obtain solution A;

[0056] 2) Add solution A to the autoclave, keep it at a constant temperature of 0.5h under the heating condition of 105°C, then cool it to room temperature, and stand for 3d to crystallize to obtain crystal B;

[0057] 3) Filter out the crystal B described in step 2). The crystal B is the calixarene-rhodamine supramolecular co-assembly.

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Abstract

The invention discloses a calixarene-rhodamine supramolecular co-assembly and its preparation method and application. Its molecular formula is C 112 h 103 o 51 N 2 S 12 , can be used as a fluorescent probe to detect Fe in aqueous solution 3+ and Pb 2+ . The supramolecular co-assembly of the invention can be used as a fluorescent detection reagent for iron ions and palladium ions in aqueous solution, and has the advantages of rapid and effective detection, good selectivity, high sensitivity, low detection cost and low requirements for equipment.

Description

technical field [0001] The present invention relates to a supramolecular co-assembly and its preparation method and application, in particular to a calixarene-rhodamine supramolecular co-assembly and its preparation method and application. Background technique [0002] Supramolecular assembly is defined as a multi-molecular group composed of non-covalent bonds, which can be as simple as two molecules. They can be complex, organized aggregates such as spherical, rod-shaped, or sheet-like, and maintain a certain integrity, giving them well-defined microstructure and macroscopic properties. [0003] Supramolecular assemblies have a wide range of applications, such as Northwestern University's Samuel 1. Stupp and his colleagues showed that the supramolecular assembly of peptide amphiphiles into nanofibers can be used to promote the growth of neurons (growth of neurons); and biological / / Self-assembling dendritic dipeptides, which form empty cylinders, assemble in solution or in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/82C07C309/42C09K11/06G01N21/64
CPCC07D311/82C07C309/42C09K11/06G01N21/6428C09K2211/1088
Inventor 肖昕岑然张威刘明冯贤豪王成会陈丽霞
Owner GUIZHOU UNIV
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