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Application of beta-nicotinamide mononucleotide in osteosarcoma cell line

A technology for osteosarcoma cells and single nucleotides, applied in the field of application of β-nicotinamide mononucleotide in osteosarcoma cell lines, can solve the problem of lack of drugs for osteosarcoma

Inactive Publication Date: 2021-10-08
黑龙江联生生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem of lack of existing drugs for the treatment of osteosarcoma, and to provide an application of β-nicotinamide mononucleotide in osteosarcoma cell lines

Method used

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  • Application of beta-nicotinamide mononucleotide in osteosarcoma cell line
  • Application of beta-nicotinamide mononucleotide in osteosarcoma cell line
  • Application of beta-nicotinamide mononucleotide in osteosarcoma cell line

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Experimental program
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specific Embodiment approach 1

[0007] Embodiment 1: This embodiment is an application of β-nicotinamide mononucleotide in osteosarcoma cell lines, and the use of β-nicotinamide mononucleotide in the preparation of anti-osteosarcoma cell line drugs.

specific Embodiment approach 2

[0008] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the osteosarcoma cell line is human osteosarcoma cell line MG-63. Others are the same as the first embodiment.

specific Embodiment approach 3

[0009] Embodiment 3: The difference between this embodiment and Embodiment 1 is: the osteosarcoma cell line is human osteosarcoma cell U2-OS. Others are the same as the first embodiment.

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Abstract

The invention provides application of beta-nicotinamide mononucleotide in an osteosarcoma cell line, and relates to application of beta-nicotinamide mononucleotide in an osteosarcoma cell line. The invention aims to solve the problem of lack of existing drugs for treating osteosarcoma. The invention also provides application of beta-nicotinamide mononucleotide in preparation of drugs for resisting osteosarcoma cell lines. The beta-nicotinamide mononucleotide can enhance the mitochondrial NAD<+> by expression, and excessive NAD<+> can promote mitochondrial respiration, lower glycolysis and counteract Warburg metabolism liked by cancer cells. The increase of NAD<+> can also increase the activity of SIRT1 and SIRT6, and both inhibit tumors by down-regulating the beta-catenin signal and down-regulating glycolysis, so that the beta-nicotinamide mononucleotide can be used for preparing drugs for resisting osteosarcoma cell lines.

Description

technical field [0001] The invention relates to the application of β-nicotinamide mononucleotide in osteosarcoma cell lines. Background technique [0002] Osteosarcoma (OS) is a primary malignant tumor derived from mesenchymal cells, which mostly occurs in children and adolescents. Clinically, the prominent symptoms of osteosarcoma are pain at the tumor site, and the gradual appearance of a mass can lead to lameness. It can also cause a series of systemic problems, such as fever, anemia, lung symptoms caused by lung metastasis, and pathological fractures. In the process of forming osteoblasts from pluripotent mesenchymal stem cells, complex signal transduction pathways and various factors are involved, and any interference in this process may lead to dysregulation of differentiation and proliferation of these cells, resulting in osteosarcoma. Therefore, The origin of osteosarcoma is multifactorial, involving complex processes such as differentiation dysregulation of mesench...

Claims

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Application Information

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IPC IPC(8): A61K31/706A61P35/00
CPCA61K31/706A61P35/00
Inventor 张忠旭温继龙曲阳
Owner 黑龙江联生生物科技有限公司
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