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Porous scaffold as well as preparation method and application thereof

A technology of porous scaffolds and porous materials, used in prosthesis, tissue regeneration, medical science and other directions, can solve the problems of short life, easy inactivation, ectopic osteogenesis, etc., achieve good mineralization, good mechanical properties, promote bone repaired effect

Active Publication Date: 2021-10-15
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to short lifespan and easy inactivation, there is sometimes a risk of ectopic osteogenesis

Method used

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  • Porous scaffold as well as preparation method and application thereof
  • Porous scaffold as well as preparation method and application thereof
  • Porous scaffold as well as preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0048] In this embodiment, a porous scaffold is prepared, and the specific process is as follows:

[0049] Calcium magnesium silicate (CMS) and graphene oxide (GO) were ultrasonicated in deionized water for 30 minutes in a mass ratio of 1:1 to obtain a CMS / GO suspension; then adding a silk fibroin solution with a mass concentration of 6%, After rapid stirring for 10 min, the prepared suspension was stored at -20°C for 12 h, and the scaffold was lyophilized under vacuum freezing. After the scaffold was immersed in ethanol for 4 h, the MES buffer containing 25 mM EDC and 50 mM NHS ( The molar concentration is 50nM; the solvent is ethanol with a volume fraction of 70%) soaking for 12h, and the mass / volume ratio of the soaking material is 0.1g / 10mL. After washing with deionized water for three times, the porous scaffold (CMS / GO / SF) was obtained by freeze-drying again.

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Abstract

The invention discloses a porous scaffold as well as a preparation method and application thereof. The porous scaffold provided by the invention has good mechanical properties, water absorption and water retention rate, can slowly release calcium, magnesium and silicon ions, and has good functions of mineralization, hemostasis promotion, osteogenic differentiation, vascularization and osteoclast differentiation inhibition. The preparation method of the porous scaffold is simple and low in cost. When the porous scaffold is applied to preparation of a bone repair material, the defects of uncontrolled drug release and short action time of active factors can be avoided, and the purpose of effectively and continuously promoting bone repair is achieved.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a porous support and its preparation method and application. Background technique [0002] In clinical practice, thousands of people suffer from a large number of bone defects every year due to various reasons such as traffic accidents, bone diseases, and tumor resection. However, effective treatments for bone repair or regeneration remain a great challenge. Bone tissue engineering based on natural biomaterials is a promising approach that has emerged in recent years and provides a suitable strategy for material design for bone defect repair or regeneration. Silk fibroin (SF), isolated from silkworm cocoons, is widely used as a tissue engineering scaffold for bone, cartilage, Repair and regeneration of ligaments and skin. However, the therapeutic effect of SF scaffolds is compromised due to lack of osteogenic and angiogenic potential, which limits its app...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/22A61L27/08A61L27/02
CPCA61L27/56A61L27/227A61L27/08A61L27/025A61L2430/02A61L2300/602A61L2300/418A61L2300/412C08L89/00
Inventor 吴婷婷林泽枫林承雄许为康
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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