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Lithium carbonate sustained release tablet

A slow-release tablet and lithium carbonate technology, which is applied in the direction of non-active ingredient medical preparations, pill delivery, inorganic active ingredients, etc., can solve the problems of unfavorable industrialized large-scale production, long drying time, large loss, etc., and achieve long-lasting effect , stable curative effect, and the effect of improving compliance

Pending Publication Date: 2021-10-22
上海葆隆生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation method needs to go through multiple pulverization processes, with a lot of dust, large loss, and too long drying time, which is not conducive to large-scale industrial production.

Method used

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  • Lithium carbonate sustained release tablet
  • Lithium carbonate sustained release tablet
  • Lithium carbonate sustained release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] prescription:

[0025]

[0026]

[0027] Preparation method: pass lithium carbonate through a 80-mesh sieve, and sieve hypromellose, lactose, stearic acid, magnesium stearate, and talcum powder through a 60-mesh sieve; take the prescription amount of lithium carbonate, hypromellose, lactose, hard Fatty acids are mixed evenly, granulated with 7.5% polyvinylpyrrolidone 75% ethanol solution containing Tween 80, dried in a fluidized bed, passed through a 20-mesh sieve for granulation, added magnesium stearate and talcum powder, mixed and compressed into tablets.

Embodiment 2

[0029] prescription:

[0030]

[0031] Preparation method: pass lithium carbonate through 80 mesh sieve, hypromellose K4M, hypromellose K15M, microcrystalline cellulose, stearic acid, sodium lauryl sulfate, calcium stearate, micropowder silica gel through 60 Mesh sieve; get the prescription amount lithium carbonate, hypromellose K4M, hypromellose K15M, microcrystalline cellulose, sodium lauryl sulfate, stearic acid and mix evenly, granulate with 75% ethanol solution, boil Bed-dried, passed through a 20-mesh sieve for granulation, added calcium stearate and micropowder silica gel, mixed and pressed into tablets.

Embodiment 3

[0033] prescription:

[0034]

[0035] Preparation method: Pass lithium carbonate through a 80-mesh sieve, hydroxyethyl cellulose, calcium sulfate, magnesium stearate, and micropowder silica gel pass through a 60-mesh sieve; take the prescription amount of lithium carbonate, hydroxyethyl cellulose, and calcium sulfate and mix evenly, The lecithin-containing 5% polyvinylpyrrolidone 75% ethanol solution is granulated, dried in a fluidized bed, sieved through a 20-mesh sieve for granulation, magnesium stearate and micropowder silica gel are added to mix and then compressed into tablets.

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PUM

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Abstract

The invention discloses a lithium carbonate sustained-release tablet. The sustained-release tablet comprises lithium carbonate, a sustained-release material and other auxiliary materials. The slow-release material is a hydrophilic gel framework material or a corrosion framework material; wherein the other auxiliary materials comprise an adhesive, a pore-foaming agent, a surfactant, a lubricant, a flow aid, a filling agent, a disintegrating agent and a wetting agent. According to the lithium carbonate sustained release tablet, the administration frequency is reduced, the peak valley phenomenon of blood concentration is avoided or reduced, stable and lasting effective blood concentration is provided, and the safety and effectiveness of the medicine are improved.

Description

technical field [0001] The invention relates to a sustained-release tablet, in particular to a lithium carbonate sustained-release tablet. Background technique [0002] Lithium carbonate is mainly used for the treatment of mania. It has a good effect on the treatment and prevention of relapse of bipolar affective disorder with alternating episodes of mania and depression, and it also has an effect on the prevention of episodes of recurrent depression. Also used to treat schizoaffective psychosis. [0003] Lithium carbonate was initially developed by Solvay and Novartis, which was later acquired by Abbott. It was first launched in the United States in 1939 under the product name Lithobid. [0004] Currently, lithium carbonate is available in dosage forms including ordinary tablets, capsules, syrups and sustained-release tablets, and the specifications include 150mg, 300mg, 450mg, and 600mg. Ordinary tablets need to be taken orally 2 to 3 times a day. Repeated use is prone ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K47/38A61K47/36A61K47/32A61K47/44A61K47/12A61K47/10A61K47/14A61K33/00A61P25/18A61P25/24
CPCA61K9/2013A61K9/2027A61K9/2054A61K33/00A61K9/205A61P25/18A61P25/24
Inventor 刘勇黄平王毅
Owner 上海葆隆生物科技有限公司
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