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Lithium carbonate sustained release tablet

A technology of sustained-release tablets and lithium carbonate, which is applied in the directions of inactive medical preparations, pill delivery, inorganic active ingredients, etc., can solve problems such as unfavorable industrialized large-scale production, excessive drying time, and excessive dust, and achieve long-lasting effects. , The effect of stable curative effect and reduction of adverse reactions

Inactive Publication Date: 2018-11-02
上海葆隆生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation method needs to go through multiple pulverization processes, with a lot of dust, large loss, and too long drying time, which is not conducive to large-scale industrial production.

Method used

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  • Lithium carbonate sustained release tablet
  • Lithium carbonate sustained release tablet
  • Lithium carbonate sustained release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] prescription:

[0025]

[0026] Preparation method: pass lithium carbonate through a 80-mesh sieve, and sieve hypromellose, lactose, stearic acid, magnesium stearate, and talcum powder through a 60-mesh sieve; take the prescription amount of lithium carbonate, hypromellose, lactose, hard Fatty acids are mixed evenly, granulated with 7.5% polyvinylpyrrolidone 75% ethanol solution containing Tween 80, dried in a fluidized bed, passed through a 20-mesh sieve for granulation, added magnesium stearate and talcum powder, mixed and compressed into tablets.

Embodiment 2

[0028] prescription:

[0029]

[0030] Preparation method: pass lithium carbonate through 80 mesh sieve, hypromellose K4M, hypromellose K15M, microcrystalline cellulose, stearic acid, sodium lauryl sulfate, calcium stearate, micropowder silica gel through 60 Mesh sieve; take prescription amount of lithium carbonate, hypromellose K4M, hypromellose K15M, microcrystalline cellulose, sodium lauryl sulfate, stearic acid and mix evenly, granulate with 75% ethanol solution, boil Bed-dried, passed through a 20-mesh sieve for granulation, added calcium stearate and micropowder silica gel, mixed and pressed into tablets.

Embodiment 3

[0032] prescription:

[0033]

[0034] Preparation method: Pass lithium carbonate through a 80-mesh sieve, hydroxyethyl cellulose, calcium sulfate, magnesium stearate, and micropowder silica gel pass through a 60-mesh sieve; take the prescription amount of lithium carbonate, hydroxyethyl cellulose, and calcium sulfate and mix evenly, The lecithin-containing 5% polyvinylpyrrolidone 75% ethanol solution is granulated, dried in a fluidized bed, sieved through a 20-mesh sieve for granulation, added magnesium stearate and micropowder silica gel to mix and then compressed into tablets.

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Abstract

The invention discloses a lithium carbonate sustained release tablet. The sustained release tablet is prepared from lithium carbonate, a sustained-release material and other ingredients. The sustained-release material is a hydrophilic gel skeleton material or an erodible matrix material, wherein the other ingredients comprise an adhesive, a pore-foaming agent, a surfactant, a lubricant, a flow aid, filler, a disintegrant and a wetting agent. The lithium carbonate sustained release tablet has the advantages that administration times are reduced, the peak and valley phenomenon of plasma-drug concentration is avoided or reduced, a stable and lasting effective plasma-drug concentration is provided and the safety and the effectiveness of a drug are improved.

Description

technical field [0001] The invention relates to a sustained-release tablet, in particular to a lithium carbonate sustained-release tablet. Background technique [0002] Lithium carbonate is mainly used for the treatment of mania. It has a good effect on the treatment and prevention of relapse of bipolar affective disorder with alternating episodes of mania and depression, and it also has an effect on the prevention of episodes of recurrent depression. Also used to treat schizoaffective psychosis. [0003] Lithium carbonate was initially developed by Solvay and Novartis, which was later acquired by Abbott. It was first launched in the United States in 1939 under the product name Lithobid. [0004] Currently, lithium carbonate is available in dosage forms including ordinary tablets, capsules, syrups and sustained-release tablets, and the specifications include 150mg, 300mg, 450mg, and 600mg. Ordinary tablets need to be taken orally 2 to 3 times a day. Repeated use is prone ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K47/38A61K47/26A61K47/32A61K47/12A61K47/02A61K47/10A61K47/20A61K47/04A61K47/24A61K33/00A61P25/18
CPCA61K9/2013A61K9/2027A61K9/2054A61K33/00A61K9/205A61P25/18A61P25/24
Inventor 刘勇黄平王毅
Owner 上海葆隆生物科技有限公司
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