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Micro-fluidic chip, micro-fluidic chip channel positioning structure and positioning method

A microfluidic chip, positioning structure technology, applied in chemical instruments and methods, material analysis by optical means, measuring devices, etc. The effect of misjudgment

Pending Publication Date: 2021-10-29
苏州索真生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But also in the process of moving in the vertical direction, affected by the accuracy of the mobile platform, the position will vary each time, and the uncertainty is greater

Method used

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  • Micro-fluidic chip, micro-fluidic chip channel positioning structure and positioning method
  • Micro-fluidic chip, micro-fluidic chip channel positioning structure and positioning method
  • Micro-fluidic chip, micro-fluidic chip channel positioning structure and positioning method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Such as figure 1 As shown, the microfluidic chip provided in this embodiment includes an initial positioning frame A, a positioning cross mark B, several microchannels C and a positioning line D.

[0070] A number of microchannels C are arranged vertically at intervals. The initial positioning frame A is set on the right side of the microchannel C, and the positioning cross mark B is set on the left side of the top of the initial positioning frame A. The positioning cross mark B is set on the extension line on the side of the center of the microchannel C. , used to locate the rightmost position of microchannel C. The left side of the microchannel C is provided with a positioning line D, and the positioning line D can be set on the extension line on the other side of the center of the microchannel C for positioning the leftmost position of the microchannel C.

[0071] In some preferred embodiments of the present invention, the longitudinal distance between adjacent micr...

Embodiment 2

[0075] Such as figure 2 , image 3 As shown, the channel positioning structure of the microfluidic chip provided in this embodiment is used to position the microfluidic chip provided in Example 1, to locate the focused spot and the channel size of the microfluidic chip, including chip pressing and photoelectric conversion module 1, Chip support structure 2, optical probe 3, micro-motion module 4, AD data acquisition module 5, data analysis module 6 and motor control module 7.

[0076] The chip pressing and photoelectric conversion module 1 is arranged above the microfluidic chip, and is used to obtain the optical signals emitted by the light source and irradiate the different positions of the microfluidic chip, and convert the optical signals into analog electrical signals.

[0077] The chip supporting structure 2 is arranged under the microfluidic chip, and is used for supporting and fixing the microfluidic chip.

[0078] The optical probe 3 is arranged under the microflui...

Embodiment 3

[0095] Based on the positioning structure of the second embodiment of the present invention, the method for positioning the microfluidic chip channel of the first embodiment includes the following steps:

[0096] S1. The microfluidic chip channel positioning structure is installed on the microfluidic chip

[0097] Specifically, when installing the channel positioning structure of the microfluidic chip in this embodiment, after the chip is pressed and the photoelectric conversion module 1 is pressed, the initial position of the optical probe 3 is placed in the initial positioning frame A, and the optical probe is ensured XY movement, such as image 3 the coordinates mentioned. And the rotation angle with the microfluidic chip is within the preset acceptable range. Preferably, the angle of rotation within the acceptable range can first be manually confirmed through the structure, and secondly can be judged by the moving waveform from point locating point ② to locating point ④,...

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Abstract

The invention relates to a micro-fluidic chip, a micro-fluidic chip channel positioning structure and a positioning method, and is characterized in that the micro-fluidic chip comprises a plurality of micro-channels, an initial positioning frame, a first positioning marking line and a second positioning marking line; the plurality of micro-channels are longitudinally arranged at intervals; the initial positioning frame is arranged on the right side of the micro-channel; the first positioning marked line is arranged on the left side of the top of the initial positioning frame, and the first positioning marked line is arranged on one side of the central extension line of the micro-channel and used for positioning the rightmost position of the micro-channel; and the second positioning marked line is arranged on the left side of the micro-channel, is arranged on the other side of the central extension line of the micro-channel and is used for positioning the leftmost position of the micro-channel. By arranging the micro-fluidic chip structure, the initial positioning precision of the whole equipment structure can be reduced.

Description

technical field [0001] The invention relates to a microfluidic chip, a microfluidic chip channel positioning structure and a positioning method, and relates to the technical field of biological detection. Background technique [0002] Microfluidic chip technology integrates the basic operation units of sample preparation, reaction, separation, and detection in the process of biological, chemical, and medical analysis into micron-scale chips, and automatically completes the entire analysis process. Due to its great potential in the fields of biology, chemistry, and medicine, it has developed into a new research field interdisciplinary in biology, chemistry, medicine, fluid, electronics, materials, and machinery. [0003] Optical focus positioning in medical microfluidic equipment. At present, when most of the equipment is produced through the equipment, after the focus is positioned through the structure, the focus position is no longer adjusted. This creates a problem. If th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/47G01N21/17B01L3/00
CPCG01N21/4788G01N21/17B01L3/5027B01L3/00
Inventor 陈谦张路刘泓杜从柱赵俊岭
Owner 苏州索真生物技术有限公司
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