Systems and methods for capillary electrophoresis, isoelectric point, and molecular weight analysis

Abstract

A system includes a housing, a cartridge retainer disposed within the housing, a detection assembly disposed within the housing, and a reagent tray holder movably disposed in the housing. The cartridge retainer configured to receive a capillary cartridge having a capillary. The detection assembly includes at least one emitter, a first detector, and a second detector. The detection assembly is configured to transition between a first configuration, in which the first detector detects a first output of the at least one emitter, and a second configuration, in which the second detector detects a second output of the at least one emitter. The reagent tray holder is configured to move relative to the cartridge retainer to place the capillary of the capillary cartridge in fluid communication witha reagent volume.

Description

[0001] This application is an invention titled "system and method for capillary electrophoresis, isoelectric point and molecular weight analysis", the filing date is January 13, 2017, the international application number is PCT / US2017 / 013470, and the national application number is 201780015587.5 A divisional application of a patent application. [0002] Cross References to Related Applications [0003] This application claims the benefit of US Provisional Patent Application No. 62 / 278,159, filed January 13, 2016, the entire disclosure of which is hereby incorporated by reference. technical field [0004] Embodiments described herein relate generally to systems and methods for electrophoretically separating and / or analyzing sample mixtures by molecular weight and / or isoelectric point. Certain embodiments described herein relate to the separation, detection, identification, classification and / or quantification of an analyte or analytes present in a sample. More specifically, e...

AI Technical Summary

Problems solved by technology

[0007] While certain methods are used to perform electrophoretic analysis to determine information associated with an analyte, protein, molecule, or the like, these methods are typically performed in complex and expensive devices capable of performing a single mode of analysis

Furthermore, certain known methods and systems involve extensive and / or time-consuming handling and handling steps that adversely affect reproducibility and make automation difficult

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