A colorimetric fluorescent probe compound for detecting fluoride ion and its detection method
A technology of fluorescent probes and compounds, applied in the field of analytical chemistry, to achieve the effects of strong fluorescence quenching, good selectivity, and obvious color changes
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[0016] Example 1. Preparation of colorimetric fluorescent probes
[0017] The synthetic route is shown in the following formula:
[0018]
[0019] Compound 3 (1.0 g, 1.44 mmol), zinc powder (0.5 g, 8.0 mmol), ammonium chloride (0.8 mg, 16.0 mmol) were dissolved in 100 mL of tetrahydrofuran. The mixture was stirred at room temperature for 3 h, and the ammonium chloride and zinc dust were removed by filtration. The crude product of the filtrate was purified by silica gel column chromatography to obtain compound 2 (0.76 g, 80%) as a dark brown solid. Compound 2 (0.4 g, 5.0 mmol) and formic acid catalyzed by paraformaldehyde (0.12 g, 4.0 mmol) were dissolved in 100 mL of ethanol and heated under reflux for 12 h. The precipitate was collected by filtration, and the crude product was purified by silica gel column chromatography (dichloromethane: ethyl acetate, 2%) to obtain the colorimetric fluorescent probe P1 of the present invention (0.25 g, 62%, M.p.: 300-302°C). 1H NMR (4...
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