Anisodamine and purification process thereof

A technology of anisodamine and anisodamine, applied in the field of medicine, can solve the problems of many impurities, poor absorption and utilization, unstable quality, etc.

Pending Publication Date: 2021-11-26
锦州拾正生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the primary extract of anisodamine often has disadvantages such as low content of active ingre

Method used

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  • Anisodamine and purification process thereof
  • Anisodamine and purification process thereof
  • Anisodamine and purification process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The embodiment of the present invention proposes a kind of purification process of anisodamine, comprising the following steps:

[0030] Grind Huashan ginseng, sieve it after grinding, and screen out 20-mesh small particles; add 0.05wt% compound enzyme solution to the small particles, and enzymolyze it at a temperature of 40°C for 3 hours, and filter and separate the mountain ginseng after enzymolysis treatment. Anisopole extract and a primary filtrate; add 70vol% ethanol to the primary filtrate to obtain an extract; the extract is distilled under reduced pressure to obtain a crude extract; add 70vol% to the mixture of the crude extract and the anisopole extract The ethanol 1 is subjected to secondary extraction and filtration to obtain the secondary filtrate; the secondary filtrate is treated with a macroporous adsorption resin, and then eluted with 50vol% ethanol 2 to obtain a purified crude liquid, and the purified crude liquid is reduced at a temperature of 50 ° C. ...

Embodiment 2

[0033] The embodiment of the present invention proposes a kind of purification process of anisodamine, comprising the following steps:

[0034] Grind Huashan ginseng, sieve after grinding, and screen out 80-mesh small particles; add 0.15wt% compound enzyme solution to the small particles, and enzymolyze it at a temperature of 35°C for 2 hours, and filter and separate the mountain ginseng after enzymolysis treatment. Anisopole extract and a primary filtrate; add 85vol% ethanol to the primary filtrate to obtain an extract; the extract is distilled under reduced pressure to obtain a crude extract; add 85vol% to the mixture of the crude extract and the anisopole extract The ethanol 1 is subjected to secondary extraction and filtration to obtain the secondary filtrate; the secondary filtrate is treated with a macroporous adsorption resin, and then eluted with 60 vol% ethanol 2 to obtain a purified crude liquid, and the purified crude liquid is reduced at a temperature of 60° C. Pre...

Embodiment 3

[0037] The embodiment of the present invention proposes a kind of purification process of anisodamine, comprising the following steps:

[0038] Grind Huashan ginseng, sieve after grinding, and screen out 45-mesh small particles; add 0.10wt% compound enzyme solution to the small particles, and enzymolyze at a temperature of 37°C for 2.5 hours, filter and separate to obtain mountain ginseng Anisopole extract and a primary filtrate; add 80vol% ethanol to the primary filtrate to obtain an extract; the extract is distilled under reduced pressure to obtain a crude extract; add 80vol% to the mixture of the crude extract and the anisopole extract The ethanol 1 is subjected to secondary extraction and filtration to obtain the secondary filtrate; the secondary filtrate is treated with a macroporous adsorption resin, and then eluted with 55vol% ethanol 2 to obtain a purified crude liquid, and the purified crude liquid is reduced at a temperature of 55° C. Pressure distillation to no etha...

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Abstract

The invention provides anisodamine and a purification process thereof, and relates to the technical field of medicines. The purification process of anisodamine comprises the following steps: adding a compound enzyme solution with a concentration of 0.05-0.15 wt% into radix physochlainae for enzymolysis treatment, and then filtering and separating to obtain an Anisodus tanguticus extract and primary filtrate; adding ethanol I into the primary filtrate for primary extraction to obtain extract liquid; carrying out reduced pressure distillation on the extract liquid to obtain a crude extract liquid; adding ethanol I into a mixture of the crude extract liquid and the Anisodus tanguticus extract for secondary extraction and filtration to obtain secondary filtrate; and carrying out reduced pressure distillation on the secondary filtrate at the temperature of 50-60 DEG C until no ethanol exists to obtain purified anisodamine. By means of the operation, the anisodamine is purified, and the physiological activity of the anisodamine can be reserved to the maximum extent. On the other hand, the invention also provides the anisodamine which is prepared by the purification process of the anisodamine. The anisodamine is relatively high in purity, relatively excellent in physiological activity and relatively good in stability.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to anisodamine and a purification process thereof. Background technique [0002] Anisodamine is mainly an alkaloid extracted from Tanguthua ginseng, a plant of the Solanaceae family. The natural product is anisodamine hydrobromide, and the synthetic product is called racemic anisodamine, both of which are M choline receptors blocker. It has the functions of relieving vasospasm (especially capillaries), improving microcirculation, relaxing smooth muscle, inhibiting glandular secretion, anti-shock, pupil dilating and analgesia, etc. It is mainly used clinically to relieve visceral smooth muscle spasm, anti-infective shock and sedation. Pain, treatment of vertigo, peripheral vascular disease, fundus disease and sudden deafness. As a national essential drug, anisodamine is still one of the most commonly used drugs in primary medical institutions. In recent years, with the gradual de...

Claims

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Application Information

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IPC IPC(8): C07D451/10
CPCC07D451/10
Inventor 于喜洋刘东滨刘千驰
Owner 锦州拾正生物科技有限公司
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