The invention discloses a flotation 
separation method for 
refractory sulfide ore and high-
sulfur copper-
zinc ore. The method comprises the following steps: performing first-stage ore 
grinding on a raw ore and then performing first-stage flotation on the raw ore, wherein the raw ore after being subjected to the first-stage ore 
grinding meets the demand that more than 90% of ore 
fineness is less than 200 meshes; adopting the processes of once rough flotation, once fine flotation and once 
scavenging; performing second-stage ore 
grinding on the ore after being subjected to the first-stage flotation, wherein 
tailings of the first-stage flotation are 
sulfur concentrates; performing second-stage flotation on the ore which is subject to the second-stage ore grinding and meets the demand that more than 90% of ore 
fineness is less than 400 meshes; performing 
copper-
zinc separation flotation; adopting the processes of once rough flotation, triple fine flotation and once 
scavenging; adding C6MT 
sodium phosphate as a modifier and separating 
copper concentrates from the 
tailings; performing third-stage flotation on the 
tailings; and adopting the processes of once rough flotation, triple fine flotation and twice 
scavenging, thereby separating 
zinc concentrates from the 
sulfur concentrates. The method provided by the invention has the advantages of reasonable process, saved investment and low cost. By using the method, the flotation precision of copper-zinc ore is increased, the 
recovery rate of copper and zinc concentrates is increased, the national mine resource is furthest recovered, utilized and protected, and the national technical level of separating copper-zinc ore is promoted.