The invention discloses a prefabricated bamboo composite pipe gallery, which is formed by connecting a plurality of prefabricated pipe joints, wherein each pipe joint comprises a pipe body, a force bearing mechanism, vertical supporting beams, a horizontal supporting beam and pipeline supports; the pipe body radially comprises a liner layer, a structure layer and an outer protection layer from inside to outside in sequence; the liner layer comprises flame-retarded resin and flame-retarded fabrics; the structure layer at least comprises a plurality of bamboo skin layers which are bonded with water soluble resin; the outer protection layer at least comprises flame-retarded resin; and the force bearing mechanism is fixed to the inner surface of the pipe body. The invention also discloses a method of manufacturing the prefabricated bamboo composite pipe gallery. The method comprises the manufacturing of the pipe body. The preparation method of the pipe body comprises the steps: (1) the liner layer is manufactured; (2) the structure layer is manufactured; and (3) the outer protection layer is manufactured. According to the invention, bamboo is utilized to manufacture a prefabricated pipe gallery, so that the intensity is good, the weight is light, the cost is low, the impermeability is good, the antiknock characteristic is strong, the construction is convenient, and the technical problems that the existing comprehensive pipe gallery consumes too many materials, the construction project amount is large, the construction period is long and the construction cost is high are solved.